You are here: Home> Taiwan>TW-REACH>CAS 101-68-8> CAS 101-68-8 | Data Package 100 - 1000 t/a (Affiliates of MDI-MDA Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-44'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-44'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-44'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-44'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the|salmonella/microsome test | Author: Herbold B Haas P Seel K and Walber U | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the|salmonella/microsome test | Author: Herbold B Haas P Seel K and Walber U | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 44'-diisocyanate (44'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 44'-diisocyanate (44'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 44'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 44'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 44'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 44'-MDI under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 44'-MDI under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR prediction of log Koc for 44'-MDI | Author: West B | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR prediction of log Koc for 44'-MDI | Author: West B | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |