CAS 119-36-8 | TR-REACH

Includes:

Study name	Short Description	Data Owner
Phys-Chem \| Appearance/physical state/colour	*Robust Study Summary* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: N.	-
Phys-Chem \| Appearance/physical state/colour	*Right to refer to study* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: N.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, [ ... ] Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate and Tridecyl Salicylate \| Author: Cosmetic Ingredient Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Handbook of environmental data on organic chemicals \| Author: VERSCHUEREN K. \| Year: 1983 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: The Parachor of Co-ordinated Hydrogen in the Ortho-substituted Phenols \| Author: Sidgwick N.V. & Bayliss N.S. \| Year: 1930 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Ammonolysis of Esters of Hydroxybenzoic Acids on a Boron Phosphate Catalyst \| Author: Suvorov B.V. Bukeikhanov N.R. Li L.V. & Zulkasheva A.Z. \| Year: 1987 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: The Parachor of Co-ordinated Hydrogen in the Ortho-substituted Phenols \| Author: Sidgwick N.V. & Bayliss N.S. \| Year: 1930 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: An efficient method for the deallylation of allyl aryl ethers using electrochemically generated nickel \| Author: Yasuhara A. Kasano A. & Sakamoto T. \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: A convenient preparation of methyl esters from carboxylic acids \| Author: Mohacsi E. \| Year: 1982 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Gefrierpunkte organischer Substanzen. \| Author: TIMMERMANS J. \| Year: 1914 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Solid-liquid phase-transfert catalysis without added solvent. A simple efficient and inexpensive synthesis of aromatic carboxylic esters by alkylation of potassium carboxylates \| Author: Barry J. et al. \| Year: 1985 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: The pyrolysis of tobacco ingredients \| Author: Baker R.R. & Bishop L.J. \| Year: 2004 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Parachor studies at various temperatures \| Author: Buehler C.A. Gardner Thomas S. & Milton L. \| Year: 1937 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Conformational Studies in Ester Hydrolysis \| Author: Radhakrishnamurty P.S. & Patra P.C. \| Year: 1970 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Ammonolysis of Esters of Hydroxybenzoic Acids on a Boron Phosphate Catalyst \| Author: Suvorov B.V. Bukeikhanov N.R. Li L.V. & Zulkasheva A.Z. \| Year: 1987 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: The Parachor of Co-ordinated Hydrogen in the Ortho-substituted Phenols \| Author: Sidgwick N.V. & Bayliss N.S. \| Year: 1930 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Densities of Mixtures of Benzene with Phenylethyl Alcohol and with Methyl Salicylate \| Author: Glowaski R.C. & Lynch C.C. \| Year: 1933 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Sorption and diffusion kinetics of binary organic mixtures of bis(2-methoxyethyl) ether with organic esters into tetrafluoroethylene + propylene copolymer membranes at 298.15K. \| Author: Aminabhavi T.M. & Phayde H.T.S. \| Year: 1996 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Determining the vapour pressures of plant volatiles from gas chromatographic retention data. \| Author: Hoskovec M. et al. \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Vapor Pressure of Pure Substances: Organic Compounds \| Author: Stull D.R. \| Year: 1947 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Methyl salicylate \| Author: GESTIS \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: The vapour pressures of pure substances: Selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region. \| Author: BOUBLIK T. FRIED V. & HALA E. \| Year: 1984 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Handbook of environmental data on organic chemicals \| Author: VERSCHUEREN K. \| Year: 1983 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Physical and Thermodynamic Properties of Pure Chemicals: Data Compilation \| Author: Daubert T.E. Danner R.P. \| Year: 1989 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Surface tension	*Robust Study Summary* -- Title: Parachor studies at various temperatures \| Author: Buehler C.A. Gardner Thomas S. & Clemens Milton L. \| Year: 1937 \| Klimisch score: 3 - Not reliable \| Adequacy: disregarded due to major methodological deficiencies.	-
Phys-Chem \| Water solubility	*Robust Study Summary* -- Title: Salicylsäuremethylester. II. Löslichkeit in Wasser bei 30°C. \| Author: Gibbs H.D. \| Year: 1909 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Water solubility	*Robust Study Summary* -- Title: Effect of Hydrotropes on Solubility and Mass Transfer Coefficient of Methyl Salicylate \| Author: Kumar M.D. & Gandhi N.N. \| Year: 2000 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: The Measurement of Partition Coefficients \| Author: Dearden J.C. & Bresnen G.M. \| Year: 1988 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, [ ... ] Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate and Tridecyl Salicylate \| Author: Cosmetic Ingredient Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: Log Kow Â©: A databank of evaluated octanol-water partition coefficient (log P) \| Author: Sangster Research Laboratories \| Year: 1994 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Solubility in organic solvents/fat solubility	*Robust Study Summary* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Guideline: 105 \| Klimisch score: 4 - Not assignable \| Adequacy: key study.	-
Phys-Chem \| Solubility in organic solvents/fat solubility	*Right to refer to study* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Guideline: 105 \| Klimisch score: 4 - Not assignable \| Adequacy: key study.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Methyl salicylate \| Author: EPA's Office of Pesticide Programs \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals 13th edition. \| Author: O'NEIL M.J. et al. \| Year: 2001 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: 2-Hydroxybenzoate de méthyle \| Author: INRS - CarAtex database \| Year: 2001 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Methyl salicylate \| Author: GESTIS \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Salicylate de méthyle \| Author: IPCS \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Auto-ignition temperature	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Auto-ignition temperature	*Robust Study Summary* -- Title: Methyl salicylate \| Author: GESTIS - Database on hazardous substances \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Auto-ignition temperature	*Robust Study Summary* -- Title: 2-Hydroxybenzoate de méthyle \| Author: INRS - CarAtex database \| Year: 2001 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Environmental \| Biodegradation in water: screening tests	*Robust Study Summary* -- Author: KING J.M.H. \| Year: 1993 \| Guideline: 301 B (Ready Biodegradability: CO2 Evolution Test) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Environmental \| Biodegradation in water: screening tests	*Robust Study Summary* -- Author: GOULDING C. GILLEN C.J. & BOLTON E. \| Year: 1988 \| Klimisch score: 3 - Not reliable \| Adequacy: supporting study.	-
Environmental \| Adsorption/desorption	*Robust Study Summary* -- Author: European Chemical Bureau \| Year: 2003 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study.	-
Environmental \| Phototransformation in air	*Robust Study Summary* -- Author: U.S. Environmental Protection Agency \| Year: 2008 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Toxicology of methyl salicylate \| Author: Castagnou R. Larceban S. Quement A. \| Year: 1952 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Comparative toxicity of diethylacetylsalicylate and methyl salicylate \| Author: Giroux J. Granger R. Monnier P. \| Year: 1954 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. I. Acute oral toxicity \| Author: Jenner P.M. et al. \| Year: 1964 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Hygienic standardization of methyl salicylate in workplace air \| Author: Rumyantsev G.I. et al. \| Year: 1992 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl-, Calcium-, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl-, Isocetyl-, Isodecyl-, Magnesium-, MEA-, Ethylhexyl-, Potassium-, Methyl-, Myristyl-, Sodium-, TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. I. Acute oral toxicity \| Author: Jenner P.M. et al. \| Year: 1964 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Esters of Aromatic Monocarboxylic Acids and Monoalcohols \| Author: Bisesi M.S. \| Year: 1994 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Monographs on fragrance raw materials. Methyl salicylate \| Author: Opdyke D.L.J. \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: On the metabolism and toxicity of methyl salicylate \| Author: Davison C. Zimmerman E.F. Smith P.K. \| Year: 1961 \| Guideline: 401 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Acute toxicity studies \| Author: RIFM \| Year: 1982 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Right to refer to study* -- Title: Acute toxicity studies \| Author: RIFM \| Year: 1982 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Esters \| Author: Fassett D.W. \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Monographs on fragrance raw materials. Methyl salicylate \| Author: Opdyke D.L.J. \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: A study on acute toxicities of essential oils used in endodontic treatment \| Author: Ohsumi T. et al. \| Year: 1984 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Hygienic standardization of methyl salicylate in workplace air \| Author: Rumyantsev G.I. et al. \| Year: 1992 \| Guideline: 403 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Guideline: 403 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Untitled \| Author: Anonymous \| Year: 1971 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: inhalation	*Right to refer to study* -- Title: Untitled \| Author: Anonymous \| Year: 1971 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: No information \| Author: Bisesi M.S. \| Year: 1994 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: Esters of Aromatic Monocarboxylic Acids and Monoalcohols \| Author: Bisesi M.S. \| Year: 1994 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: Acute toxicity studies on rats and rabbits. Report to RIFM 12th November \| Author: Moreno O.M. \| Year: 1973 \| Guideline: 402 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Guideline: 402 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Acute toxicity studies on rats and rabbits report to RIFM 12th November \| Author: Moreno O.M. \| Year: 1973 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: HR 99/130785: Primary skin Irritation in the Rabbit Not owned by SEQENS \| Author: Schreiter U. \| Year: 1999 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: HR 99/130785: Primary skin Irritation in the Rabbit Not owned by SEQENS \| Author: Schreiter U. \| Year: 1999 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Esters \| Author: Fassett D.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Mechanisms of chemically induced skin irritation. I. Studies of time course dose response and components of inflammation in the laboratory mouse \| Author: Patrick E. Maibach H.I. Burkhalter A. \| Year: 1985 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Report on eye irritation study of methyl salicylate in rabbits \| Author: RIFM \| Year: 1963 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Dangerous properties of Industrial Materials \| Author: Sax N.I. Lewis R.J. \| Year: 1992 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: YMS PHARMACEUTICAL METHYL SALICYLATE: Short Time Exposure in vitro Test Method for Identifying Eye Damage \| Author: M. Roth \| Year: 2019 \| Guideline: 491 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: YMS PHARMACEUTICAL METHYL SALICYLATE: Short Time Exposure in vitro Test Method for Identifying Eye Damage \| Author: M. Roth \| Year: 2019 \| Guideline: 491 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Esters \| Author: Fassett D.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: In vitro ocular irritancy testing \| Author: Douglas W.H.J. Spilman S.D. \| Year: 1983 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Chemical burns of the rabbit cornea \| Author: Carpenter C.P. Smyth H.F. \| Year: 1946 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 405 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 405 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Examination of the Local Lymph Node Assay for Use in Contact Sensitization Risk Assessment \| Author: Gerberick G.F. House R.V. Fletcher E.R. Ryan C.A. \| Year: 1992 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Structure activity relationships in skin sensitization using the murine local lymph node assay \| Author: Ashby J. Basketter D.A. Paton D. and Kimber I. \| Year: 1995 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: QSAR Study of Skin Sensitization using Local lymph Node Assay Data \| Author: Fedorowicz A. Zheng L. Singh H. Demchuk E. \| Year: 2004 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods \| Author: Klecak G. Geleick H. Frey J.R. \| Year: 1977 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Local lymph node activation and IgE responses in Brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals \| Author: Arts J.H.E. et al. \| Year: 1997 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Comparison of the local lymph node assay with the guinea pig maximization test for the detection of a range of contact allergens \| Author: Basketter D.A. Scholes E.W. \| Year: 1992 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The murine local lymph node assay: results of an inter-laboratory trial \| Author: Kimber I. et al. \| Year: 1991 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Strategies for identifying false positive responses in predictive skin sensitization tests \| Author: Basketter D.A. Gerberick G.F. Kimber I. \| Year: 1998 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation \| Author: Kimber I. et al. \| Year: 1998 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Murine local lymph node assay for predictive testing of allergenicity: Two irritants caused significant proliferation \| Author: Montelius J. et al. \| Year: 1998 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The murine local lymph node assay: results of an inter-laboratory trial \| Author: Kimber I. et al. \| Year: 1991 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The optimization test in the guinea pig in relation to other predictive sensitization methods \| Author: Maurer T.H. Weirich E.G. Hess R. \| Year: 1980 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The performance of the local lymph nose assay with chemicals identified as contact allergens in the human maximization test \| Author: Basketter D.A. Scholes E.W. Kimber I. \| Year: 1994 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Experience with the murine local lymph node assay: Inability to discriminate between allergens and irritants \| Author: Montelius J. Wahlkvist H. Boman A. \| Year: 1994 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Comparison of the local lymph node assay with the guinea pig maximization test for the detection of a range of contact allergens \| Author: Basketter D.A. Scholes E.W. \| Year: 1992 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay \| Author: Adenuga D. Woolhiser M.R. Gollapudi B.B. Boverhof D.R. \| Year: 2012 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver, and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Ultrastructural alterations of hepatic microbodies \| Author: Hruban Z. Swift H. Slesers A. \| Year: 1966 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Methyl salicylate: reproduction and fertility assessment in CD-1 mice when administered by gavage \| Author: National Toxicology Program \| Year: 1982 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. II. Subacute and chronic toxicity \| Author: Hagan E.C. et al. \| Year: 1967 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Salicylates and other hydroxybenzoates: Effect upon osseous tissue of young rats. \| Author: Harrisson J.W.E. Abbott D.D. Packman E.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Salicylates and other hydroxybenzoates: Effect upon osseous tissue of young rats \| Author: Harrisson J.W.E. Abbott D.D. Packman E.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs, rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats \| Author: FDA \| Year: 1966 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic oral toxicity of oil sweet birch (methyl salicylate) \| Author: Packman E.W. et al. \| Year: 1961 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. II. Subacute and chronic toxicity \| Author: Hagan E.C. et al. \| Year: 1967 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Subacute inhalation toxicity of 109 industrial chemicals \| Author: Gage J.C. \| Year: 1970 \| Guideline: 412 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Hygienic standardization of methyl salicylate in workplace air \| Author: Rumyantsev G.I. et al. \| Year: 1992 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl-, Calcium-, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl-, Isocetyl-, Isodecyl-, Magnesium-, MEA-, Ethylhexyl-, Potassium-, Methyl-, Myristyl-, Sodium-, TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Repeated dose toxicity: dermal	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 3 - Not reliable \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Robust Study Summary* -- Title: Cell mutation assay at the thymidine kinase locus (TK+/-) in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 \| Author: Wollny H-E \| Year: 2008 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Right to refer to study* -- Title: Cell mutation assay at the thymidine kinase locus (TK+/-) in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 \| Author: Wollny H-E \| Year: 2008 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: The proportions of mutagens among chemicals in commerce \| Author: Zeiger E. Margolin B.H. \| Year: 2000 \| Guideline: EU Method B.13/14 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Primary mutagenicity screening of food additives currently used in Japan \| Author: Ishidate M. et al. \| Year: 1984 \| Guideline: 471 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Robust Study Summary* -- Title: Primary mutagenicity screening of food additives currently used in Japan \| Author: Ishidate M. et al. \| Year: 1984 \| Guideline: 473 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Robust Study Summary* -- Title: The action of transition metals on the genotoxicity of simple phenols phenolic acids and cinnamic acids. \| Author: Stich H.F. Rosin M.P. Wu C.H. Powrie W.D. \| Year: 1981 \| Guideline: 473 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study.	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals \| Author: Mortelmans K. et al. \| Year: 1986 \| Guideline: EU Method B.13/14 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproduction studies on sodium meclofenamate in comparison to acetylsalicylic acid and phenylbutazone. \| Author: Schardein J.L. Blatz A.T. Woosley E.T. Kaump D.H. \| Year: 1969 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. \| Author: National Toxicology Program \| Year: 1984 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies \| Author: Chapin R.E. Sloane R.A. \| Year: 1997 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice \| Author: Morrissey R.E. et al. \| Year: 1989 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: RAC Opinion proposing harmonised classification and labelling at EU level of Methyl salicylate (EC Number: 204-317-7; CAS Number: 119-36-8) \| Author: ECHA \| Year: 2019 \| Klimisch score: 4 - Not assignable \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Pharmacology / Toxicology review and evaluation. FS-67 Patch (10% Methyl salicylate & 3% l-menthol Topical patch) \| Author: FDA \| Year: 2006 \| Klimisch score: 4 - Not assignable \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats \| Author: FDA \| Year: 1966 \| Guideline: EU Method B.34 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Guideline: EU Method B.34 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. \| Author: National Toxicology Program \| Year: 1984 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies \| Author: Chapin R.E. Sloane R.A. \| Year: 1997 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice \| Author: Morrissey R.E. et al. \| Year: 1989 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl Salicylate: Swiss CD-1 mice at 0.0 25 50 and 100 mg/kg by gavage \| Author: Lamb IV J.C. Reel J.R. Tyl R. Lawton A.D. \| Year: 1997 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Effect on methyl salicylate on rat reproduction \| Author: Collins T.F.X. Hansen W.H. Keeler H.V. \| Year: 1971 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Evaluation of safety for food additives: An illustration involving the influence of methyl salicylate on rat reproduction \| Author: Gross M.A. Fitzhugh O.G. \| Year: 1977 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Evaluation of the teratogenic potential of fresh-brewed coffee and caffeine in the rat. \| Author: Palm P.E. et al. \| Year: 1978 \| Guideline: 415 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Teratogenic and reproductive effects of ethanol in Long-Evans rats. \| Author: Mankes R.F. et al. \| Year: 1982 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) \| Author: Geiger D.L. Northcott C.E. Call D.J. and Brooke L.T. \| Year: 1985 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Methyl salicylate: Acute toxicity for freshwater fish (96 Hours) Danio rerio \| Author: LICATA-MESSANA L. \| Year: 2000 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Eco-Tox \| Short-term toxicity to fish	*Right to refer to study* -- Title: Methyl salicylate: Acute toxicity for freshwater fish (96 Hours) Danio rerio \| Author: LICATA-MESSANA L. \| Year: 2000 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) \| Author: Geiger D.L. et al. \| Year: 1985 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de seize substances chimiques. \| Author: DION M. \| Year: 1983 \| Guideline: NF T 90301 1983 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Right to refer to study* -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de seize substances chimiques. \| Author: DION M. \| Year: 1983 \| Guideline: NF T 90301 1983 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: Acute toxicity of benzoic acids to the crustacean Daphnia magna \| Author: Kamaya Y. Fukaya Y .and Suzuki K. \| Year: 2005 \| Guideline: 202 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: Ethyl Salicylate: Acute Immobilisation Test (48h) to Daphnia magna STRAUS \| Author: NOACK M. \| Year: 2001 \| Guideline: 202 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Right to refer to study* -- Title: Ethyl Salicylate: Acute Immobilisation Test (48h) to Daphnia magna STRAUS \| Author: NOACK M. \| Year: 2001 \| Guideline: 202 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Robust Study Summary* -- Title: MethylSalicylate (CAS: 119-36-8): ALGAL GROWTH INHIBITION TEST - PROJECT NUMBER: 1975/0003 \| Author: Vryenhoef H. and Mullee D.M. \| Year: 2010 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Right to refer to study* -- Title: MethylSalicylate (CAS: 119-36-8): ALGAL GROWTH INHIBITION TEST - PROJECT NUMBER: 1975/0003 \| Author: Vryenhoef H. and Mullee D.M. \| Year: 2010 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Robust Study Summary* -- Title: Salicylates : Screening de toxicité sur algues d'eau douce Pseudokirchneriella subcapitata \| Author: CERBELAUD E. \| Year: 2000 \| Guideline: 201 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Right to refer to study* -- Title: Salicylates : Screening de toxicité sur algues d'eau douce Pseudokirchneriella subcapitata \| Author: CERBELAUD E. \| Year: 2000 \| Guideline: 201 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Toxicity to microorganisms	*Robust Study Summary* -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 \| Author: STERNALSKI R. \| Year: 1992 \| Guideline: Draft standard ISO/CD 10712 (1990-10-10) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Eco-Tox \| Toxicity to microorganisms	*Right to refer to study* -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 \| Author: STERNALSKI R. \| Year: 1992 \| Guideline: Draft standard ISO/CD 10712 (1990-10-10) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-

Study name	Short Description	Data Owner
Phys-Chem \| Appearance/physical state/colour	*Robust Study Summary* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: N.	-
Phys-Chem \| Appearance/physical state/colour	*Right to refer to study* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: N.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, [ ... ] Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate and Tridecyl Salicylate \| Author: Cosmetic Ingredient Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Handbook of environmental data on organic chemicals \| Author: VERSCHUEREN K. \| Year: 1983 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: The Parachor of Co-ordinated Hydrogen in the Ortho-substituted Phenols \| Author: Sidgwick N.V. & Bayliss N.S. \| Year: 1930 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Ammonolysis of Esters of Hydroxybenzoic Acids on a Boron Phosphate Catalyst \| Author: Suvorov B.V. Bukeikhanov N.R. Li L.V. & Zulkasheva A.Z. \| Year: 1987 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: The Parachor of Co-ordinated Hydrogen in the Ortho-substituted Phenols \| Author: Sidgwick N.V. & Bayliss N.S. \| Year: 1930 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: An efficient method for the deallylation of allyl aryl ethers using electrochemically generated nickel \| Author: Yasuhara A. Kasano A. & Sakamoto T. \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: A convenient preparation of methyl esters from carboxylic acids \| Author: Mohacsi E. \| Year: 1982 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Gefrierpunkte organischer Substanzen. \| Author: TIMMERMANS J. \| Year: 1914 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Solid-liquid phase-transfert catalysis without added solvent. A simple efficient and inexpensive synthesis of aromatic carboxylic esters by alkylation of potassium carboxylates \| Author: Barry J. et al. \| Year: 1985 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: The pyrolysis of tobacco ingredients \| Author: Baker R.R. & Bishop L.J. \| Year: 2004 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Parachor studies at various temperatures \| Author: Buehler C.A. Gardner Thomas S. & Milton L. \| Year: 1937 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Conformational Studies in Ester Hydrolysis \| Author: Radhakrishnamurty P.S. & Patra P.C. \| Year: 1970 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Ammonolysis of Esters of Hydroxybenzoic Acids on a Boron Phosphate Catalyst \| Author: Suvorov B.V. Bukeikhanov N.R. Li L.V. & Zulkasheva A.Z. \| Year: 1987 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: The Parachor of Co-ordinated Hydrogen in the Ortho-substituted Phenols \| Author: Sidgwick N.V. & Bayliss N.S. \| Year: 1930 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Densities of Mixtures of Benzene with Phenylethyl Alcohol and with Methyl Salicylate \| Author: Glowaski R.C. & Lynch C.C. \| Year: 1933 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study.	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Sorption and diffusion kinetics of binary organic mixtures of bis(2-methoxyethyl) ether with organic esters into tetrafluoroethylene + propylene copolymer membranes at 298.15K. \| Author: Aminabhavi T.M. & Phayde H.T.S. \| Year: 1996 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Determining the vapour pressures of plant volatiles from gas chromatographic retention data. \| Author: Hoskovec M. et al. \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Vapor Pressure of Pure Substances: Organic Compounds \| Author: Stull D.R. \| Year: 1947 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Methyl salicylate \| Author: GESTIS \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: The vapour pressures of pure substances: Selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region. \| Author: BOUBLIK T. FRIED V. & HALA E. \| Year: 1984 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Handbook of environmental data on organic chemicals \| Author: VERSCHUEREN K. \| Year: 1983 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Physical and Thermodynamic Properties of Pure Chemicals: Data Compilation \| Author: Daubert T.E. Danner R.P. \| Year: 1989 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Surface tension	*Robust Study Summary* -- Title: Parachor studies at various temperatures \| Author: Buehler C.A. Gardner Thomas S. & Clemens Milton L. \| Year: 1937 \| Klimisch score: 3 - Not reliable \| Adequacy: disregarded due to major methodological deficiencies.	-
Phys-Chem \| Water solubility	*Robust Study Summary* -- Title: Salicylsäuremethylester. II. Löslichkeit in Wasser bei 30°C. \| Author: Gibbs H.D. \| Year: 1909 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Water solubility	*Robust Study Summary* -- Title: Effect of Hydrotropes on Solubility and Mass Transfer Coefficient of Methyl Salicylate \| Author: Kumar M.D. & Gandhi N.N. \| Year: 2000 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: The Measurement of Partition Coefficients \| Author: Dearden J.C. & Bresnen G.M. \| Year: 1988 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, [ ... ] Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate and Tridecyl Salicylate \| Author: Cosmetic Ingredient Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: Log Kow Â©: A databank of evaluated octanol-water partition coefficient (log P) \| Author: Sangster Research Laboratories \| Year: 1994 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study.	-
Phys-Chem \| Solubility in organic solvents/fat solubility	*Robust Study Summary* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Guideline: 105 \| Klimisch score: 4 - Not assignable \| Adequacy: key study.	-
Phys-Chem \| Solubility in organic solvents/fat solubility	*Right to refer to study* -- Title: Safety Data Sheet \| Author: Rhodia \| Year: 2010 \| Guideline: 105 \| Klimisch score: 4 - Not assignable \| Adequacy: key study.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: The Dictionary of Substances and their effects \| Author: GANGOLLI S. \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Methyl salicylate \| Author: EPA's Office of Pesticide Programs \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals 13th edition. \| Author: O'NEIL M.J. et al. \| Year: 2001 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: 2-Hydroxybenzoate de méthyle \| Author: INRS - CarAtex database \| Year: 2001 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Methyl salicylate \| Author: GESTIS \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Flash point	*Robust Study Summary* -- Title: Salicylate de méthyle \| Author: IPCS \| Year: 1999 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Phys-Chem \| Auto-ignition temperature	*Robust Study Summary* -- Title: Sax's Dangerous Properties of Industrial Materials \| Author: LEWIS R.J. \| Year: 1996 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Auto-ignition temperature	*Robust Study Summary* -- Title: Methyl salicylate \| Author: GESTIS - Database on hazardous substances \| Year: 1999 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Phys-Chem \| Auto-ignition temperature	*Robust Study Summary* -- Title: 2-Hydroxybenzoate de méthyle \| Author: INRS - CarAtex database \| Year: 2001 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Environmental \| Biodegradation in water: screening tests	*Robust Study Summary* -- Author: KING J.M.H. \| Year: 1993 \| Guideline: 301 B (Ready Biodegradability: CO2 Evolution Test) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Environmental \| Biodegradation in water: screening tests	*Robust Study Summary* -- Author: GOULDING C. GILLEN C.J. & BOLTON E. \| Year: 1988 \| Klimisch score: 3 - Not reliable \| Adequacy: supporting study.	-
Environmental \| Adsorption/desorption	*Robust Study Summary* -- Author: European Chemical Bureau \| Year: 2003 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study.	-
Environmental \| Phototransformation in air	*Robust Study Summary* -- Author: U.S. Environmental Protection Agency \| Year: 2008 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Toxicology of methyl salicylate \| Author: Castagnou R. Larceban S. Quement A. \| Year: 1952 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Comparative toxicity of diethylacetylsalicylate and methyl salicylate \| Author: Giroux J. Granger R. Monnier P. \| Year: 1954 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. I. Acute oral toxicity \| Author: Jenner P.M. et al. \| Year: 1964 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Hygienic standardization of methyl salicylate in workplace air \| Author: Rumyantsev G.I. et al. \| Year: 1992 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl-, Calcium-, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl-, Isocetyl-, Isodecyl-, Magnesium-, MEA-, Ethylhexyl-, Potassium-, Methyl-, Myristyl-, Sodium-, TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. I. Acute oral toxicity \| Author: Jenner P.M. et al. \| Year: 1964 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Esters of Aromatic Monocarboxylic Acids and Monoalcohols \| Author: Bisesi M.S. \| Year: 1994 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Monographs on fragrance raw materials. Methyl salicylate \| Author: Opdyke D.L.J. \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: On the metabolism and toxicity of methyl salicylate \| Author: Davison C. Zimmerman E.F. Smith P.K. \| Year: 1961 \| Guideline: 401 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Acute toxicity studies \| Author: RIFM \| Year: 1982 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Right to refer to study* -- Title: Acute toxicity studies \| Author: RIFM \| Year: 1982 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Guideline: 401 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Esters \| Author: Fassett D.W. \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Monographs on fragrance raw materials. Methyl salicylate \| Author: Opdyke D.L.J. \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: A study on acute toxicities of essential oils used in endodontic treatment \| Author: Ohsumi T. et al. \| Year: 1984 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Hygienic standardization of methyl salicylate in workplace air \| Author: Rumyantsev G.I. et al. \| Year: 1992 \| Guideline: 403 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Guideline: 403 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Untitled \| Author: Anonymous \| Year: 1971 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: inhalation	*Right to refer to study* -- Title: Untitled \| Author: Anonymous \| Year: 1971 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: No information \| Author: Bisesi M.S. \| Year: 1994 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: Esters of Aromatic Monocarboxylic Acids and Monoalcohols \| Author: Bisesi M.S. \| Year: 1994 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: Acute toxicity studies on rats and rabbits. Report to RIFM 12th November \| Author: Moreno O.M. \| Year: 1973 \| Guideline: 402 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Acute toxicity: dermal	*Robust Study Summary* -- Title: Fragrance material review on methyl salicylate \| Author: Lapczynski A. et al. \| Year: 2007 \| Guideline: 402 \| Klimisch score: 4 - Not assignable \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Acute toxicity studies on rats and rabbits report to RIFM 12th November \| Author: Moreno O.M. \| Year: 1973 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: HR 99/130785: Primary skin Irritation in the Rabbit Not owned by SEQENS \| Author: Schreiter U. \| Year: 1999 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: HR 99/130785: Primary skin Irritation in the Rabbit Not owned by SEQENS \| Author: Schreiter U. \| Year: 1999 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Esters \| Author: Fassett D.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Mechanisms of chemically induced skin irritation. I. Studies of time course dose response and components of inflammation in the laboratory mouse \| Author: Patrick E. Maibach H.I. Burkhalter A. \| Year: 1985 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Report on eye irritation study of methyl salicylate in rabbits \| Author: RIFM \| Year: 1963 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Dangerous properties of Industrial Materials \| Author: Sax N.I. Lewis R.J. \| Year: 1992 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: YMS PHARMACEUTICAL METHYL SALICYLATE: Short Time Exposure in vitro Test Method for Identifying Eye Damage \| Author: M. Roth \| Year: 2019 \| Guideline: 491 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: YMS PHARMACEUTICAL METHYL SALICYLATE: Short Time Exposure in vitro Test Method for Identifying Eye Damage \| Author: M. Roth \| Year: 2019 \| Guideline: 491 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Esters \| Author: Fassett D.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: In vitro ocular irritancy testing \| Author: Douglas W.H.J. Spilman S.D. \| Year: 1983 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Chemical burns of the rabbit cornea \| Author: Carpenter C.P. Smyth H.F. \| Year: 1946 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 405 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 405 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Examination of the Local Lymph Node Assay for Use in Contact Sensitization Risk Assessment \| Author: Gerberick G.F. House R.V. Fletcher E.R. Ryan C.A. \| Year: 1992 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Structure activity relationships in skin sensitization using the murine local lymph node assay \| Author: Ashby J. Basketter D.A. Paton D. and Kimber I. \| Year: 1995 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: QSAR Study of Skin Sensitization using Local lymph Node Assay Data \| Author: Fedorowicz A. Zheng L. Singh H. Demchuk E. \| Year: 2004 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods \| Author: Klecak G. Geleick H. Frey J.R. \| Year: 1977 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Local lymph node activation and IgE responses in Brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals \| Author: Arts J.H.E. et al. \| Year: 1997 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Comparison of the local lymph node assay with the guinea pig maximization test for the detection of a range of contact allergens \| Author: Basketter D.A. Scholes E.W. \| Year: 1992 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The murine local lymph node assay: results of an inter-laboratory trial \| Author: Kimber I. et al. \| Year: 1991 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Strategies for identifying false positive responses in predictive skin sensitization tests \| Author: Basketter D.A. Gerberick G.F. Kimber I. \| Year: 1998 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation \| Author: Kimber I. et al. \| Year: 1998 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Murine local lymph node assay for predictive testing of allergenicity: Two irritants caused significant proliferation \| Author: Montelius J. et al. \| Year: 1998 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The murine local lymph node assay: results of an inter-laboratory trial \| Author: Kimber I. et al. \| Year: 1991 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The optimization test in the guinea pig in relation to other predictive sensitization methods \| Author: Maurer T.H. Weirich E.G. Hess R. \| Year: 1980 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: The performance of the local lymph nose assay with chemicals identified as contact allergens in the human maximization test \| Author: Basketter D.A. Scholes E.W. Kimber I. \| Year: 1994 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Methyl salicylate: Safety Assessment Screen Comprising: Acute eye irritation and delayed dermal sensitisation \| Author: Longobardi C. \| Year: 2001 \| Guideline: 406 (Skin Sensitisation) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Experience with the murine local lymph node assay: Inability to discriminate between allergens and irritants \| Author: Montelius J. Wahlkvist H. Boman A. \| Year: 1994 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Comparison of the local lymph node assay with the guinea pig maximization test for the detection of a range of contact allergens \| Author: Basketter D.A. Scholes E.W. \| Year: 1992 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay \| Author: Adenuga D. Woolhiser M.R. Gollapudi B.B. Boverhof D.R. \| Year: 2012 \| Guideline: 429 (Skin Sensitisation: Local Lymph Node Assay) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver, and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Ultrastructural alterations of hepatic microbodies \| Author: Hruban Z. Swift H. Slesers A. \| Year: 1966 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Methyl salicylate: reproduction and fertility assessment in CD-1 mice when administered by gavage \| Author: National Toxicology Program \| Year: 1982 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. II. Subacute and chronic toxicity \| Author: Hagan E.C. et al. \| Year: 1967 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Salicylates and other hydroxybenzoates: Effect upon osseous tissue of young rats. \| Author: Harrisson J.W.E. Abbott D.D. Packman E.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Salicylates and other hydroxybenzoates: Effect upon osseous tissue of young rats \| Author: Harrisson J.W.E. Abbott D.D. Packman E.W. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs, rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats \| Author: FDA \| Year: 1966 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic oral toxicity of oil sweet birch (methyl salicylate) \| Author: Packman E.W. et al. \| Year: 1961 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Food flavorings and compounds of related structure. II. Subacute and chronic toxicity \| Author: Hagan E.C. et al. \| Year: 1967 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Subacute inhalation toxicity of 109 industrial chemicals \| Author: Gage J.C. \| Year: 1970 \| Guideline: 412 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Hygienic standardization of methyl salicylate in workplace air \| Author: Rumyantsev G.I. et al. \| Year: 1992 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid, Butyloctyl-, Calcium-, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl-, Isocetyl-, Isodecyl-, Magnesium-, MEA-, Ethylhexyl-, Potassium-, Methyl-, Myristyl-, Sodium-, TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| Repeated dose toxicity: dermal	*Robust Study Summary* -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits \| Author: Webb W.K. Hansen W.H. \| Year: 1963 \| Klimisch score: 3 - Not reliable \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Robust Study Summary* -- Title: Cell mutation assay at the thymidine kinase locus (TK+/-) in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 \| Author: Wollny H-E \| Year: 2008 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Right to refer to study* -- Title: Cell mutation assay at the thymidine kinase locus (TK+/-) in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 \| Author: Wollny H-E \| Year: 2008 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: The proportions of mutagens among chemicals in commerce \| Author: Zeiger E. Margolin B.H. \| Year: 2000 \| Guideline: EU Method B.13/14 \| Klimisch score: 4 - Not assignable \| Adequacy: other information.	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Primary mutagenicity screening of food additives currently used in Japan \| Author: Ishidate M. et al. \| Year: 1984 \| Guideline: 471 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Robust Study Summary* -- Title: Primary mutagenicity screening of food additives currently used in Japan \| Author: Ishidate M. et al. \| Year: 1984 \| Guideline: 473 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Robust Study Summary* -- Title: The action of transition metals on the genotoxicity of simple phenols phenolic acids and cinnamic acids. \| Author: Stich H.F. Rosin M.P. Wu C.H. Powrie W.D. \| Year: 1981 \| Guideline: 473 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study.	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals \| Author: Mortelmans K. et al. \| Year: 1986 \| Guideline: EU Method B.13/14 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproduction studies on sodium meclofenamate in comparison to acetylsalicylic acid and phenylbutazone. \| Author: Schardein J.L. Blatz A.T. Woosley E.T. Kaump D.H. \| Year: 1969 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. \| Author: National Toxicology Program \| Year: 1984 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies \| Author: Chapin R.E. Sloane R.A. \| Year: 1997 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice \| Author: Morrissey R.E. et al. \| Year: 1989 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. \| Author: Abbott D.D. Harrisson J.W.E. \| Year: 1978 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: RAC Opinion proposing harmonised classification and labelling at EU level of Methyl salicylate (EC Number: 204-317-7; CAS Number: 119-36-8) \| Author: ECHA \| Year: 2019 \| Klimisch score: 4 - Not assignable \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Pharmacology / Toxicology review and evaluation. FS-67 Patch (10% Methyl salicylate & 3% l-menthol Topical patch) \| Author: FDA \| Year: 2006 \| Klimisch score: 4 - Not assignable \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats \| Author: FDA \| Year: 1966 \| Guideline: EU Method B.34 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate \| Author: Cosmetic Ingredients Review Expert Panel \| Year: 2003 \| Guideline: EU Method B.34 \| Klimisch score: 4 - Not assignable \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. \| Author: National Toxicology Program \| Year: 1984 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies \| Author: Chapin R.E. Sloane R.A. \| Year: 1997 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice \| Author: Morrissey R.E. et al. \| Year: 1989 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Methyl Salicylate: Swiss CD-1 mice at 0.0 25 50 and 100 mg/kg by gavage \| Author: Lamb IV J.C. Reel J.R. Tyl R. Lawton A.D. \| Year: 1997 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Effect on methyl salicylate on rat reproduction \| Author: Collins T.F.X. Hansen W.H. Keeler H.V. \| Year: 1971 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Evaluation of safety for food additives: An illustration involving the influence of methyl salicylate on rat reproduction \| Author: Gross M.A. Fitzhugh O.G. \| Year: 1977 \| Guideline: 416 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Evaluation of the teratogenic potential of fresh-brewed coffee and caffeine in the rat. \| Author: Palm P.E. et al. \| Year: 1978 \| Guideline: 415 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Teratogenic and reproductive effects of ethanol in Long-Evans rats. \| Author: Mankes R.F. et al. \| Year: 1982 \| Klimisch score: 3 - Not reliable \| Adequacy: other information.	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) \| Author: Geiger D.L. Northcott C.E. Call D.J. and Brooke L.T. \| Year: 1985 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Methyl salicylate: Acute toxicity for freshwater fish (96 Hours) Danio rerio \| Author: LICATA-MESSANA L. \| Year: 2000 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Eco-Tox \| Short-term toxicity to fish	*Right to refer to study* -- Title: Methyl salicylate: Acute toxicity for freshwater fish (96 Hours) Danio rerio \| Author: LICATA-MESSANA L. \| Year: 2000 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) \| Author: Geiger D.L. et al. \| Year: 1985 \| Guideline: 203 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de seize substances chimiques. \| Author: DION M. \| Year: 1983 \| Guideline: NF T 90301 1983 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Right to refer to study* -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de seize substances chimiques. \| Author: DION M. \| Year: 1983 \| Guideline: NF T 90301 1983 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: Acute toxicity of benzoic acids to the crustacean Daphnia magna \| Author: Kamaya Y. Fukaya Y .and Suzuki K. \| Year: 2005 \| Guideline: 202 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: Ethyl Salicylate: Acute Immobilisation Test (48h) to Daphnia magna STRAUS \| Author: NOACK M. \| Year: 2001 \| Guideline: 202 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y.	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Right to refer to study* -- Title: Ethyl Salicylate: Acute Immobilisation Test (48h) to Daphnia magna STRAUS \| Author: NOACK M. \| Year: 2001 \| Guideline: 202 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Robust Study Summary* -- Title: MethylSalicylate (CAS: 119-36-8): ALGAL GROWTH INHIBITION TEST - PROJECT NUMBER: 1975/0003 \| Author: Vryenhoef H. and Mullee D.M. \| Year: 2010 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Right to refer to study* -- Title: MethylSalicylate (CAS: 119-36-8): ALGAL GROWTH INHIBITION TEST - PROJECT NUMBER: 1975/0003 \| Author: Vryenhoef H. and Mullee D.M. \| Year: 2010 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Robust Study Summary* -- Title: Salicylates : Screening de toxicité sur algues d'eau douce Pseudokirchneriella subcapitata \| Author: CERBELAUD E. \| Year: 2000 \| Guideline: 201 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Right to refer to study* -- Title: Salicylates : Screening de toxicité sur algues d'eau douce Pseudokirchneriella subcapitata \| Author: CERBELAUD E. \| Year: 2000 \| Guideline: 201 \| Klimisch score: 3 - Not reliable \| Adequacy: weight of evidence \| GLP: N.	-
Eco-Tox \| Toxicity to microorganisms	*Robust Study Summary* -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 \| Author: STERNALSKI R. \| Year: 1992 \| Guideline: Draft standard ISO/CD 10712 (1990-10-10) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-
Eco-Tox \| Toxicity to microorganisms	*Right to refer to study* -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 \| Author: STERNALSKI R. \| Year: 1992 \| Guideline: Draft standard ISO/CD 10712 (1990-10-10) \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N.	-

CAS 119-36-8 | Data Package 10 - 100 t/a

Includes: