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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Final Report - Desmodur N3300 | Author: Prüm M. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | GLP: x. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Final Report - Desmodur N3300 | Author: Prüm M. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | GLP: x. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of the melting point of Desmodur N 3300 according to OECD 102 resp. EU A.1 | Author: LAUS GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: 102 | GLP: x. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of the melting point of Desmodur N 3300 according to OECD 102 resp. EU A.1 | Author: LAUS GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: 102 | GLP: x. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of the boiling point of Desmodur N 3300 according to OECD 103 resp. EU A.2 | Author: LAUS GmbH | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: 103 | GLP: x. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of the boiling point of Desmodur N 3300 according to OECD 103 resp. EU A.2 | Author: LAUS GmbH | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: 103 | GLP: x. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Untersuchungsbericht Physikalische Daten von N3300 roh | Author: Keldenich/Krasemann | Year: 2009 | Guideline: A.3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: A.3 | GLP: x. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Untersuchungsbericht Physikalische Daten von N3300 roh | Author: Keldenich/Krasemann | Year: 2009 | Guideline: A.3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: A.3 | GLP: x. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Prüfbericht (nach DIN EN 45001) der Proben N75M Z 4470 N 3300 Desmodur. | Author: Heitmann/ Krasemann | Year: 2008 | Guideline: DIN EN 45001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: DIN EN 45001 | GLP: x. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Prüfbericht (nach DIN EN 45001) der Proben N75M Z 4470 N 3300 Desmodur. | Author: Heitmann/ Krasemann | Year: 2008 | Guideline: DIN EN 45001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: DIN EN 45001 | GLP: x. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H,3H,5H)-trione 1,3,5-tris(6-isocyanatohexyl)- (CAS No. 3779-63-3) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of the Vapour Pressure of Desmodur N 3300 according to OECD 104 resp. EU A.4 | Author: LAUS GmbH | Year: 2010 | Guideline: A.4 | Klimisch score: 1 - Reliable without restriction | Adequacy: A.4 | GLP: x. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of the Vapour Pressure of Desmodur N 3300 according to OECD 104 resp. EU A.4 | Author: LAUS GmbH | Year: 2010 | Guideline: A.4 | Klimisch score: 1 - Reliable without restriction | Adequacy: A.4 | GLP: x. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H3H5H)-trione 1,3,5-tris(6-isocyanatohexyl)- (CAS No. 3779-63-3) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H3H5H)-trione 1,3,5-tris(6-isocyanatohexyl)- (CAS No. 3779-63-3) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H,3H,5H)-trione, 1,3,5-tris(6-aminohexyl) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H,3H,5H)-trione, 1,3,5-tris(6-aminohexyl) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Phys-Chem | Water solubility | Waiver | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Duranate TKA100 (Lot. 30318): Reverse Mutation Assay "Ames Test" using Salmonella Typhimurium and Escherichia coli | Author: Thompson P W | Year: 2004 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Asahi Kasei |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht (nach DIN EN 45001) der Proben N75M Z 4470 N 3300 Desmodur | Author: Heitkamp / Krasemann | Year: 1997 | Guideline: DIN EN 45001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: DIN EN 45001 | GLP: x. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht (nach DIN EN 45001) der Proben N75M Z 4470 N 3300 Desmodur | Author: Heitkamp / Krasemann | Year: 1997 | Guideline: DIN EN 45001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: DIN EN 45001 | GLP: x. | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Mellert W | Year: 2006 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Covestro | BASF | Vencorex | Evonik |
| Phys-Chem | Oxidising properties | Waiver | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Amendment No. 1 to the Report In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Landsiedel R | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Covestro | BASF | Vencorex | Evonik |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Lehrbuch der organischen Chemie. | Author: Beyer H., Walter W., Franke W. | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Tolonate HDT: Micronucleus Test in Bone Marrow of CD-1 mice | Author: Holmstrom M & McGregor D B | Year: 1986 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | Vencorex France |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: NCO-Abnahme in Wasser | Author: Meissner | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Right to refer to study -- Title: NCO-Abnahme in Wasser | Author: Meissner | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Phys-Chem | Stability: thermal, sunlight, metals | Robust Study Summary -- Title: Classification of the corrosivity of Desmodur N3300 according to UN test method for dangerous goods, part III, section 37, class 8 | Author: A. Tulke | Year: 2011 | Guideline: The requirements of the UN procedure for the classification for dangerous goods, part III, section 37, class 8, 34.4 test methods for corrosion to metals. | Klimisch score: 2 - Reliable with restrictions | Adequacy: The requirements of the UN procedure for the classification for dangerous goods, part III, section 37, class 8, 34.4 test methods for corrosion to metals. | GLP: x. | - |
| Phys-Chem | Stability: thermal, sunlight, metals | Right to refer to study -- Title: Classification of the corrosivity of Desmodur N3300 according to UN test method for dangerous goods, part III, section 37, class 8 | Author: A. Tulke | Year: 2011 | Guideline: The requirements of the UN procedure for the classification for dangerous goods, part III, section 37, class 8, 34.4 test methods for corrosion to metals. | Klimisch score: 2 - Reliable with restrictions | Adequacy: The requirements of the UN procedure for the classification for dangerous goods, part III, section 37, class 8, 34.4 test methods for corrosion to metals. | GLP: x. | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: 1,6-Diisocyanatohexan homopolymer Eye Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Covestro |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Determination of the viscosity of Desmodur N 3300 | Author: LAUS GmbH | Year: 2010 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: 114 | GLP: x. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Determination of the viscosity of Desmodur N 3300 | Author: LAUS GmbH | Year: 2010 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: 114 | GLP: x. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: HDI oligomers, isocyanurate type (EC no. 931-274-8, CAS no. 28182-81-2); Information/Assumptions regarding toxicokinetics | Author: Karthaus | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: HDI oligomers, isocyanurate type (EC no. 931-274-8, CAS no. 28182-81-2); Information/Assumptions regarding toxicokinetics | Author: Karthaus | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | GLP: x. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Duranate TPA100 (Lot. 30157): Acute oral toxicity in the rat - Acute Toxic Class Method | Author: Pooles A | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: 423 | GLP: x. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Duranate TKA100 (Lot. 30318): Reverse Mutation Assay "Ames Test" using Salmonella Typhimurium and Escherichia coli | Author: Thompson P W | Year: 2004 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: 471 | GLP: x. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Duranate TKA100 (Lot. 30318): Reverse Mutation Assay "Ames Test" using Salmonella Typhimurium and Escherichia coli | Author: Thompson P W | Year: 2004 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: 471 | GLP: x. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Desmodur N 3300, Salmonella/Microsome Test to evaluate for point mutagenic effects | Author: Herbold B A | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: 471 | GLP: x. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro chromosome aberration assay in V79 cells with HDI Trimer | Author: Schulz M Landsiedel R | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: 473 | GLP: x. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro chromosome aberration assay in V79 cells with HDI Trimer | Author: Schulz M Landsiedel R | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: 473 | GLP: x. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro gene mutation test in CHO cells with HDI Trimer Amendment No. 1 to the Report In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Mellert W Schulz M & Landsiedel R | Year: 2007 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: 476 | GLP: x. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro gene mutation test in CHO cells with HDI Trimer Amendment No. 1 to the Report In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Mellert W Schulz M & Landsiedel R | Year: 2007 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: 476 | GLP: x. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: TPA-100: L5178Y TK +/- Mouse Lymphoma Assay | Author: Durward R & Flanders L | Year: 2004 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: 476 | GLP: x. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: TPA-100: L5178Y TK +/- Mouse Lymphoma Assay | Author: Durward R & Flanders L | Year: 2004 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: 476 | GLP: x. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Tolonate HDT: Micronucleus Test in Bone Marrow of CD-1 mice | Author: Holmstrom M & McGregor D B | Year: 1986 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: 474 | GLP: x. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Tolonate HDT: Micronucleus Test in Bone Marrow of CD-1 mice | Author: Holmstrom M & McGregor D B | Year: 1986 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: 474 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3300 Untersuchungen zur akuten inhalativen Toxizität | Author: Pauluhn J | Year: 1984 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: 403 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3300 Untersuchungen zur akuten inhalativen Toxizität | Author: Pauluhn J | Year: 1984 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: 403 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3300 (HDI-Homopolymer), Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6-hours) 1st revised final report PH31158 as of 2001-07-09, Desmodur N 3300 (HDI Homopolymer), Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6-hours) Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymer (HDI-IC) Aerosol: Results of Single Inhalation Exposure Studies | Author: Pauluhn J Pauluhn J public | Year: 2001 2007 2000 | Guideline: TRGS 430 | Klimisch score: 1 - Reliable without restriction | Adequacy: TRGS 430 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3300 (HDI-Homopolymer), Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6-hours) 1st revised final report PH31158 as of 2001-07-09, Desmodur N 3300 (HDI Homopolymer), Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6-hours) Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymer (HDI-IC) Aerosol: Results of Single Inhalation Exposure Studies | Author: Pauluhn J Pauluhn J public | Year: 2001 2007 2000 | Guideline: TRGS 430 | Klimisch score: 1 - Reliable without restriction | Adequacy: TRGS 430 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3390 Untersuchungen zur akuten Inhalationstoxizität | Author: Pauluhn J | Year: 1985 | Guideline: OECD 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: OECD 403 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3390 Untersuchungen zur akuten Inhalationstoxizität | Author: Pauluhn J | Year: 1985 | Guideline: OECD 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: OECD 403 | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3300, Orientierende Untersuchungen zum sensorischen Reizpotential an der Maus (RD50-Bestimmung) | Author: Pauluhn J | Year: 1990 | Guideline: RD 50-study | Klimisch score: 2 - Reliable with restrictions | Adequacy: RD 50-study | GLP: x. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3300, Orientierende Untersuchungen zum sensorischen Reizpotential an der Maus (RD50-Bestimmung) | Author: Pauluhn J | Year: 1990 | Guideline: RD 50-study | Klimisch score: 2 - Reliable with restrictions | Adequacy: RD 50-study | GLP: x. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Duranate TKA100 (Lot. 30318): Acute dermal toxicity (Limit Test) in the rat | Author: Pooles A | Year: 2004 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: 402 | GLP: x. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Duranate TKA100 (Lot. 30318): Acute dermal toxicity (Limit Test) in the rat | Author: Pooles A | Year: 2004 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: 402 | GLP: x. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Tolonate HDT: Acute Percutaneous Toxicity Study in the Rabbit | Author: Myers R C & Christopher S M | Year: 1991 | Guideline: EPA Health Effects Test Guidelines (40 CFR 798) | Klimisch score: 1 - Reliable without restriction | Adequacy: EPA Health Effects Test Guidelines (40 CFR 798) | GLP: x. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Tolonate HDT: Acute Percutaneous Toxicity Study in the Rabbit | Author: Myers R C & Christopher S M | Year: 1991 | Guideline: EPA Health Effects Test Guidelines (40 CFR 798) | Klimisch score: 1 - Reliable without restriction | Adequacy: EPA Health Effects Test Guidelines (40 CFR 798) | GLP: x. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: 1,6-Diisocyanatohexan homopolymer Eye Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: 405 | GLP: x. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: 1,6-Diisocyanatohexan homopolymer Eye Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: 405 | GLP: x. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: 1,6-Diisocyanatohexan homopolymer Skin Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: 404 | GLP: x. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: 1,6-Diisocyanatohexan homopolymer Skin Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: 404 | GLP: x. | - |