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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition (Internet Version 2010) | Author: Lide D.R. ed. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde | Author: Chemsafe | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde | Author: Reaxys | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Kirk-Othmer Encyclopedia of Chemical Technology - Aldehydes | Author: Kirk-Othmer | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Reregistration Eligibility Decision for Formaldehyde and Paraformaldehyde) | Author: EPA | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Technische Entwicklung - Erstarrungstemperatur von Lutropur FEG 20 | Author: BASF | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The vapour-pressure curve of formaldehyde and some related data | Author: Spence R., Wild W. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Unknown | Author: Harries | Year: 1901 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Yaws' handbook of physical properties for hydrocarbons and chemicals physical properties for more than 41 000 organic and inorganic chemical compounds. Coverage for C1 to C100 organics and Ac to Zr inorganics. | Author: Yaws C.L. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Yaws' Thermophysical Properties of Chemicals and Hydrocarbons | Author: Yaws C.L. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Formaldehyd | Author: Römpp Chemie Lexikon | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Formaldehyde | Author: GESTIS - Substance database | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed.). | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Unknown | Author: Maslov Yu.P. Maslov P.G. | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Reregistration Eligibility Decision for Formaldehyde and Paraformaldehyde | Author: EPA | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Zur Kenntniss des Formaldehyds | Author: Kekulé A. | Year: 1892 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampf-Flüssiggleichgewicht im System Formaldehyd Wasser | Author: BASF | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampf-Flüssiggleichgewicht im System Formaldehyd Wasser | Author: BASF | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Data Compilation Tables of Properties of Pure Compounds. | Author: Daubert T. E., Danner R. P. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: FORMALDEHYDE (50-00-0) | Author: Boublik T., Fried V., Hala E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Stoffwerte wässrige Formaldehyd-Lösung 40 % | Author: BASF | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Stoffwerte wässrige Formaldehyd-Lösung 40 % | Author: BASF | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The vapour pressure of pure substances - Selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region | Author: Boublik T., Fried V., Hala E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The Vapour Pressures of Pure Substances. Second Revised Edition | Author: Boublik T., Fried V., Hala E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The vapour-pressure curve of formaldehyde and some related data | Author: Spence R., Wild W. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Unknown | Author: Mali Ghosh | Year: 1925 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde Release rate coefficients from selected consumer products. | Author: Pickrell J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde Release rate coefficients from selected consumer products. | Author: Pickrell J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde Release rate coefficients from selected consumer products. | Author: Pickrell J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr., Lewis R. J. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition (Internet Version 2010) | Author: Lide D.R. ed. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyd | Author: Römpp Chemie Lexikon | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde | Author: GESTIS - Substance database | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde | Author: The Finnish Environment Institute (SYKE) | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde Health And Safety Guide | Author: World Health Organization | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Handbook of Environmental Data on Organic Chemicals 4th Edition | Author: Verschueren K. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Knovel Solvents: A Properties Database - A comprehensive collection of property information for over 1600 different solvents. | Author: Wypych G. ed. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. | Author: NIOSH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Reregistration Eligibility Decision for Formaldehyde and Paraformaldehyde | Author: EPA | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials. 13 ed. | Author: National Fire Protection Association | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Formaldehyde | Author: Chemical Risk Information Platform (CHRIP) | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr., Lewis R. J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: No information | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: No information | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht | Author: BASF | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht | Author: BASF | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht | Author: BASF SE | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht | Author: BASF SE | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht - Kopie | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht - Kopie | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed.) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition (Internet Version 2010) | Author: Lide D.R. ed. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Formaldehyd | Author: Römpp Chemie Lexikon | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Knovel Solvents: A Properties Database - A comprehensive collection of property information for over 1600 different solvents. | Author: Wypych G. ed. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: unknown | Author: Legrand J. et al. | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Unknown | Author: Vanpée M. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Fire Protection Guide on Hazardous Materials 5th ed. | Author: National Fire Protection Association | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Formaldehyde | Author: Chemsafe | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Knovel Solvents: A Properties Database - A comprehensive collection of property information for over 1600 different solvents. | Author: Wypych G. ed. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: EPI Suite calculation for CAS No. 50-00-0 | Author: BASF | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: EPI Suite calculation for CAS No. 50-00-0 | Author: BASF | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.10 | Author: US-EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Exploring QSAR - Hydrophobic Electronic and Steric Constants. | Author: Hansch C., Leo A. D., Hoekman | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Handbook of Environmental Data on Organic Chemicals 4th Edition | Author: Verschueren K. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values | Author: Smith C.J. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficients of Simple Organic Compounds | Author: Sangster J. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: The Relative Toxicity of Compounds in Mainstream Cigarette Smoke Condensate | Author: Smith C. J., Hansch C. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Yaws' Handbook of Properties for Environmental and Green Engineering | Author: Yaws C.L. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Reactive scavenging of pollutants by rain: a modeling approach | Author: Kumar | Year: 1986 | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: DOC Die-Away Test Ready Biodegradability of Formaldehyde (30 - 55 % W/W aqueous solution) by activated sludge | Author: Fraunhofer IME | Year: 2011 | Guideline: 301A | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: DOC Die-Away Test Ready Biodegradability of Formaldehyde (30 - 55 % W/W aqueous solution) by activated sludge | Author: Fraunhofer IME | Year: 2011 | Guideline: 301A | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Formaldehyde biodegradation in the presence of methanol under denitrifying conditions. | Author: Eiroa M et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Mackay Level I calculation | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Mackay Level I calculation | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The biodegradability and inhibitory threshold concentration of some disinfectants. | Author: Gerike P Gode P | Year: 1990 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The Official Bulletin of Economy Trade and Industry | Author: National Institute of Technology and Evaluation Japan | Year: 1989 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 30525-89-4 | EC 608-494-5 | 30525-89-4) |
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| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Data assessment 15 Jan 2008 | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Data assessment 15 Jan 2008 | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: EPIwin calculation formaldehyde | Author: BASF | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: EPIwin calculation formaldehyde | Author: BASF | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.10 | Author: US-EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Efficacy and Toxicity of Formalin Solutions Containing Paraformaldehyde for Fish and Egg Treatments | Author: Howe G.E: et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizität mit dem Goldorfentest. | Author: Juhnke I, Lüdemann D | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Formalin: Its Toxicity to Nontarget Aquatic Organisms Persistence and Counteraction. | Author: Bills TD Marking LL Chandler JH | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Histopathological evaluation of formalin toxicity in Arapaima gigas (Arapaimidae) the giant fish from Amazon | Author: Andrade-Porto Sanny M. et al. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Lethal Doses of Several Commercial Chemicals for Fingerling Channel Catfish | Author: Clemens H.P. and K.E. Sneed | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Polychlorinated Biphenyl (Arochlor 1254)Residues in Rainbow Trout: Effects on Sensitivity to Nine Fishery Chemicals | Author: Bills T.D. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Sensitivity of Juvenile Striped Bass to Chemicals used in Aquaculture | Author: Bills T. D. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: The Chemical Control of Some Diseases and Parasites of Channel Catfish | Author: Clemens H.P. and K.E. Sneed | Year: 1958 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: The toxicity of nine therapeutic and herbicidal compounds to striped bass. | Author: Wellborn T | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity and Tolerance Studies with Yellow-Phase Eels: Five Chemicals | Author: Hinton M.J. and Eversole A.G. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of 22 Therapeutic Compounds to Six Fishes | Author: Willford W.A. | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of formalin to bullseye puffer fish (Sphoeroides annulatus Jenyns 1843) and its effectiveness to control ectoparasites | Author: Fajer-Ávila EJ et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Four Chemotherapeutic Agents to Rabbitfish Siganus rivulatus | Author: Nasser N et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Ten Chemicals Commonly Used in Aquaculture to the Black Eel Stage of the American Eel | Author: Hinton M.J. and Eversole A.G. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Ten Commonly Used Chemicals to American Eels | Author: Hinton M.J. and Eversole A.G. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicology Handbook: Mammalian and aquaticdata. Book 1 Toxicology data | Author: Schneider B.A. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Trimmed SpearmanKarber method for estimating median lethal concentrations in toxicity bioassays. | Author: Hamilton MA, Russo RC, Thurston RV | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Use of Formalin for selective control of tadpoles in the presence of fishes | Author: Helms D. R. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Vergleich der Empfindlichkeit von Brachydanio rerio und Leuciscus idus bei der Untersuchung der Fischtoxizität von chemischen Verbindungen und Abwässern. | Author: Wellens H | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxic and genotoxic effects of formalin in Danio rerio (zebrafish) | Author: Resendes A.S., dos Santos D.S., França F.M. et al | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) volume V. | Author: Geiger DL Brooke LT Call DJ | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickelten standardisierten Testverfahren. | Author: Bringmann G, Kuehn R | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Formalin: Its Toxicity to Nontarget Aquatic Organisms Persistence and Counteraction. | Author: Bills TD, Marking LL, Chandler JH | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Rapid toxicity screening tests for aquatic biota. 1. Methodology and experiments with Daphnia magna | Author: Janssen CR, Persoone G | Year: 1993 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Toxicity of Laundry Detergent Components to a Freshwater Cladoceran and Their Contribution to Detergent Toxicity | Author: Warne M.St.J, Schifko A.D. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of formaldehyde to the pearl oyster Pinctada fucata martensii | Author: Takayanagi K et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Befunde der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna | Author: Bringmann G., Kuehn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparative assessment of toxicity of phenol formaldehyde and industrial wastewater to aquatic organisms | Author: Tisler T, Zagorc-Koncan J | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Estimating low-toxic-effect concentrations in closed-system algal toxicity tests | Author: Chen Wang Yang | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Individual and Combined Toxicity of Nitriles and Aldehydes to Raphidocelis subcapitata | Author: Chen CY, Chen SL, Christensen ER | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity assessment of pesticides to Pseudokirchneriella subcapitata under air-tight test environment. | Author: Yeh H.J., Chen C.Y. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity assessment of polycyclic aromatic hydrocarbons using an air-tight algal toxicity test. | Author: Chen C.Y., Yan Y.K., Yang C.F. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: An algal toxicity data base of organic toxicants derived by a closed system technique. | Author: Tsai K.P., Chen C.Y | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Comparative studies on algal toxicity testing using fluorometric microplate and Erlenmeyer flask growth-inhibition assays | Author: Eisentraeger A et al. | Year: 2003 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Evaluation of the OECD activated sludge respiration test | Author: Klecka GM, Landi LP, Bodner KM | Year: 1985 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: The biodegradability and inhibitory treshold concentration of some disinfectants | Author: Gerike P., Gode P. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparative assessment of toxicity of phenol formaldehyde and industrial wastewater to aquatic organisms | Author: Tisler T, Zagorc-Koncan J | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Determination of Formaldehyde in biological tissues by gas chromatography/mass spectrometry | Author: Heck H, White El, Casanova-Schmitz M | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Distribution of [14C]formaldehyde in rats after inhalation exposure | Author: Heck H, Chin TY, Casanova-Schmitz M | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: DNA-Protein Cross-links and Cell Replication at Specific Sites in the Nose of F344 Rats Exposed Subchronically to Formaldehyde | Author: Casanova M et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dosimetry Modeling of Inhaled Formaldehyde: Comparisons of Local FIux Predictions in the Rat Monkey and Human Nasal Passages | Author: J. S. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dosimetry modeling of inhaled formaldehyde: the human respiratory tract | Author: Overton JH, Kimbell JS, Millert FJ | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability | Author: Garcia GJM et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of Endogenous Formaldehyde in Nasal Tissues on Inhaled Formaldehyde Dosimetry Predictions in the Rat Monkey and Human Nasal Passages | Author: Schroeter J.D. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of formaldehyde gas on the respiratory tract of rhesus monkeys | Author: Monticello TM et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Electrophoretic Investigation of Formaldehyde Dehydrogenase from Human Tissues | Author: Castle S, Board P | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Experimental setup and analytical methods for the non-invasive determination of volatile organic compounds formaldehyde and NOx in exhaled human breath | Author: Riess U. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa | Author: Hedberg JJ et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Expression of formaldehyde dehydrogenase and S-formylglutathione hydrolase activities in different rat tissues | Author: Uotila L Koivusalo M | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Expression of formaldehyde dehydrogenyse and S-formylglutathione hydrolase activities in different rat tissues | Author: Uotila L Koivusalo M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions | Author: Heck HA et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde concentrations in the blood of Rhesus monkeys after inhalation exposure | Author: Casanova M et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde in drinking water: comparative hazard evaluation and an approach to regulation | Author: Owen BA et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde Toxicity - DNA-protein cross-linking studies in rats and nonhuman primates | Author: Heck HA et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde: Integrating Dosimetry Cytotoxicity and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound | Author: Andersen M.E. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde-oral toxicity assessment | Author: Cascieri TC Clary JJ | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehydoxydation bei der Ratte | Author: Rietbrock N | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promotor | Author: Hedberg J.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Further studies on the metabolic incorporation and covalent binding of inhaled 3H- and 14C-formaldehyde in Fischer-344 rats: effect of glutathione | Author: Casanova M Heck H | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Genetic polymorphisms in the formaldehyde dehydrogenase gene and their biological significance | Author: Just W. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Glutathione-dependent oxidoreductases: formaldehyde dehydrogenase | Author: Uotila L Koivusalo M | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Histochemical localization of formaldehyde dehydrogenase in the rat | Author: Keller DA et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset | Author: Conolly R.B. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Inhibition of the low-km mitochondrial aldehyde dehydrogenase by diethyl maleate and phorone in vivo and in vitro | Author: Dicker E, Cederbaum AI | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Investigations of potential susceptibility toward formaldehyde-induced genotoxicity | Author: Zeller J. et al | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Is individual nasal sensitivity related to cellular metabolism of formaldehyde and susceptibility towards formaldehyde-induced genotoxicity? | Author: Zeller J. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Isotope effects and their implications for the covalent binding of inhaled [3H]- and [14C]Formaldehyde in the rat nasal mucosa | Author: Heck H, Casanova M | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase | Author: Sanghani PC et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Kinetik und Wege des Methanolumsatzes (Kinetics and Pathways of Methanol Metabolsm) | Author: Rietbrock N | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Lack of a role for formaldehyde in methanol poisoning in the monkey | Author: McMartin KE et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Mammalian alcohol dehydrogenase - functional and structural implications | Author: Höög JO et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Monomorphism of formaldehyde dehydrogenase in different populations | Author: Benkmann HG et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Multiple forms of formaldehyde dehydrogenase from human red blood cells | Author: Uotila L, Koivusalo M | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Nasal cavity deposition histopathology and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats | Author: Chang JCF et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Nasal dosimetry of formaldehyde: modelling site specificity and the effects of preexposure | Author: Heck H Casanova M | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydrogenases in rat nasal mucosal homogenates | Author: Casanova-Schmitz M, David R, Heck H | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Reactions of hydrated formaldehyde in nasal mucus | Author: Priha E et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Sensitivity Analysis of Biologically Motivated Model for Formaldehyde-Induced Respiratory Cancer in Humans | Author: Crump K.S. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Site-directed mutagenesis and enzyme properties of mammalian alcohol dehydrogenases correlated with their tissue distribution. | Author: Höög JO, Estonius M, Danielsson O. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Study on absorption and elimination of the test substance Basfin in male rats after single application in comparison to absorption and elimination of its synthesis components formaldehyde and urea | Author: BASF AG | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Study on absorption and elimination of the test substance Basfin in male rats after single application in comparison to absorption and elimination of its synthesis components formaldehyde and urea | Author: BASF AG | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The determination of exogenous formaldehyde in blood of rats during and after inhalation exposure | Author: Kleinnijenhuis A.J. et al. | Year: 2013 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The fate of formaldehyde in rats after single exposure by inhalation. | Author: TNO Triskelion | Year: 2012 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: The fate of formaldehyde in rats after single exposure by inhalation. | Author: TNO Triskelion | Year: 2012 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis | Author: Miller F.J. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Uncertainties in Biologically-Based Modeling of Formaldehyde-Induced Respiratory Cancer Risk: Identification of Key Issues | Author: Subramaniam R.P. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis-I. | Author: Subramaniam R.P. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Xenobiotic-metabolizing enzymes in the canine respiratory tract | Author: Maier KL et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A lung dosimetry model of vapor uptake and tissue disposition | Author: Asgharian B. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A mathematical model for the absorption and metabolism of formaldehyde vapour by humans | Author: Franks SJ | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A novel bottom-up approach to bounding low-dose human cancer risks from chemical exposures | Author: Starr T.B. Swenberg J.A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Alcohol dehydrogenase in human tissues: localization of transcripts coding for five classes of the enzyme | Author: Estonius M, Svensson S, Höög JO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination | Author: Cassee FR Feron VJ | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Breath gas aldehydes as biomarkers of lung cancer | Author: Fuchs P. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: CICAD No. 40 Formaldehyde | Author: WHO | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of Rhesus monkeys: Pharmacokinetics rat-to-monkey interspecies scaling and extrapolation to man | Author: Casanova M et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Disposition of 14C-formaldehyde after topical exposure to rats guinea pigs and monkeys | Author: Jeffcoat AR et al. | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous absorption of formaldehyde in rats | Author: Bartnik FG, Gloxhuber C, Zimmermann V | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: The in vitro permeability of human skin to benzene ethylene glycol formaldehyde and n-Hexane | Author: Loden M | Year: 1986 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicity of formaldehyde in experimental animals - concentrations of the chemical in the elution from dishes of formaldehyde resin in some vegetables | Author: Tsuchiya K et al. | Year: 1975 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Distribution progression and recovery of acute formaldehyde-induced inhibition of nasal mucociliary function in F-344 rats | Author: Morgan KT, Gross EA, Patterson DL | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats | Author: Chang JCF, Steinhagen WH, Barrow CS | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effects of acute exposure to formaldehyde on surface morphology of nasal epithelia in rats | Author: Bhalla DK et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde; Acute inhalation toxicity study in Wistar rats 4-hour vapor exposure (whole body) | Author: BASF | Year: 2015 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Formaldehyde; Acute inhalation toxicity study in Wistar rats 4-hour vapor exposure (whole body) | Author: BASF | Year: 2015 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Report on the inhalation hazard test in rats with 1% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Report on the inhalation hazard test in rats with 1% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Report on the inhalation hazard test in rats with 2.5 % formaldehyde solution in water | Author: BASF | Year: 1981 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Report on the inhalation hazard test in rats with 2.5 % formaldehyde solution in water | Author: BASF | Year: 1981 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Report on the inhalation hazard test in rats with 5% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Report on the inhalation hazard test in rats with 5% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: The single dose toxicity of some glycols and derivatives | Author: Smyth HF, Seaton J, Fischer L | Year: 1941 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: [General toxic and allergic action of formaldehyde] [Article in Russian] | Author: Nagornyj PA, Sudakova ZhA, Shchablenko SM | Year: 1979 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: A toxicological investigation of lower aliphatic aldehydes | Author: Skog E | Year: 1950 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin | Author: Futamura M. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits. | Author: Arts J.H.E., de Heer C., Woutersen R. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nocireceptive neurons by formaldehyde | Author: Tian L.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Odor irritation and perception of health risk | Author: Dalton P. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Raw data of the study on the primary skin irritation of formalin | Author: BASF | Year: 1973 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Raw data of the study on the primary skin irritation of formalin | Author: BASF | Year: 1973 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Report on the study of the primary skin irritation of formalin | Author: BASF | Year: 1974 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Report on the study of the primary skin irritation of formalin | Author: BASF | Year: 1974 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Transient Receptor Potential Vanilloid 1 - a Polymodal Nociceptive Receptor - Plays a Crucial Role in Formaldehyde-Induced Skin Inflammation in Mice | Author: Usuda H. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: A simple method for screening assessment of skin and eye irritation | Author: Sekizawa J. et al. | Year: 1994 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Characterization of Skin Inflammation Induced by Repeated Exposure of Toluene Xylene and Formaldehyde in Mice | Author: Saito A. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Ocular Injury by Transient Formaldehyde Exposure in a Rabbit Eye Model | Author: Lai L.J. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: A simple method for screening assessment of skin and eye irritation | Author: Sekizawa J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Chemical burns of the rabbit cornea | Author: Carpenter C.P., Smith H.F. | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Effect of prolonged and repeated exposure to formaldehyde donors wih doses below the EC3 value on draining Lymph node responses | Author: DeJong W.H. et al. | Year: 2007 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde | Author: Hilton J. et al. | Year: 1998 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Experimental assessment of the sensitizing properties of formaldehyde | Author: Hilton J. et al. | Year: 1996 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Experimental assessment of the sensitizing properties of formaldehyde | Author: Hilton J. et al. | Year: 1996 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Formaldehyde solution. Study on sensitizing properties in Pirbright White guinea pigs according to MAGNUSSON and KLIGMAN | Author: Hoechst A.G. | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Formaldehyde solution. Study on sensitizing properties in Pirbright White guinea pigs according to MAGNUSSON and KLIGMAN | Author: Hoechst A.G. | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1987 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1987 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Human potency predictions for aldehydes using the local lymph node assay | Author: Basketter D.A. et al. | Year: 2001 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Induction of formaldehyde sensitivity in guinea pigs | Author: Lee H.K., Alarie Y., Karol M.H. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Interlaboratory validation of 1 % pluronic L92 surfactant as a suitable aqueous vehicle for testing pesticide formulations using the murine local lymph node assay | Author: Boverhof D.R. et al. | Year: 2008 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Local lymph node activation and IgE responses in brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals | Author: Arts J.H. et al. | Year: 1997 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The murine local lymph node assay: results of an inter-laboratory trial | Author: Kimber I. et al. | Year: 1991 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The murine local lymph node assay: results of an inter-laboratory trial | Author: Kimber I. et al. | Year: 1991 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Usefulness and limitations of various guinea-pig test methods in detecting human skin sensitizers - validation of guinea-pig tests for skin hypersensitivity | Author: Marzulli F., Maguire H.C. | Year: 1982 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Comparison of cytokine secretion profiles provoked|in mice by glutaraldehyde and formaldehyde | Author: Dearman R.J. et al. | Year: 1999 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Effects of formaldehyde in the rat and dog following oral exposure | Author: Johannsen FR, Levinskas GL, Tegeris AS | Year: 1986 | Guideline: 409 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking water study in rats | Author: Til HP et al. | Year: 1988 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Sperm count morphology and fluorescent body frequency in autopsy service workers exposed to formaldehyde | Author: Ward JB et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subacute immunotoxicity study of formaldehyde in male rats | Author: Vargova M et al. | Year: 1993 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde. | Author: WHO | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat | Author: Andersen ME et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation of formaldehyde does not induce systemic genotoxic effects in rats | Author: Speit G et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Localization and quantitation of cell proliferation following exposure to nasal irritants | Author: Swenberg JA, Gross EA, Randall HW | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Lowest adverse effects concentrations (LOAECs) for formaldehyde exposure | Author: Gelbke HP, Gröters S, Morfeld P | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Mechanism of formaldehyde toxicity | Author: Swenberg JA et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde | Author: Monticello TM, Miller F, Morgan K | Year: 1991 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Responses of the nasal mucociliary apparatus of F-344 rats to formaldehyde gas | Author: Morgan KT, Patterson DL, Gross EA | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subacute (4-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposure. | Author: Wilmer JW et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic (13 week) inhalation toxicity study of formaldehyde in rats: 8-hour intermittent versus 8-hour continuous exposures | Author: Wilmer JW et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic (13 week) inhalation toxicity study of formaldehyde in rats: 8-hour intermittent versus 8-hour continuous exposures | Author: Directorate-General of Labour Ministry of Social Affairs and Employment Netherlands | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: The effect of formaldehyde exposure on cytotoxicity and cell proliferation | Author: Swenberg JA et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Ultrastructiiral evaluation of acute nasal toxicity in the rat respiratory epithelium in response to formaldehyde gas | Author: Monteiro-Riviere NA and Popp JA | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 26-week inhalation toxicity study with formaldehyde in the monkey rat and hamster | Author: Rusch GM et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells | Author: Monticello TM et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104 | Author: Marnett LJ et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test results for 250 chemicals. | Author: Haworth S et al. | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity strain specifities need for metabolism and correlation with rodent carcinogenicity | Author: Kamber M et al. | Year: 2009 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: Comparison of results for 22 compounds in two laboratories | Author: Galloway SM et al. | Year: 1985 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Epigenetic Changes Induced by Air Toxics: Formaldehyde Exposure Alters miRNA Expression Profiles in Human Lung Cells | Author: Rager et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Exposure of human nasal epithelial cells to formaldehyde does not lead to DNA damage in lymphocytes after co-cultivation | Author: Neuss S, Moepps B, Speit G | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA repair pathway | Author: Rosado I.V. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells | Author: Ji Z. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde induces toxic effects and regulates the expression of damage response genes in BM-MSCs | Author: She Y. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde: in vitro human lymphocyte clastogenicity testing | Author: Boots Company | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Formaldehyde: in vitro human lymphocyte clastogenicity testing | Author: Boots Company | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced and spontaneous alterations in human HPRT DNA sequence and mRNA expression | Author: Liber HL et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced cytotoxic genotoxic and mutagenic response in human lymphocytes and Salmonella typhimurium | Author: Schmid E, Göggelmann W, Bauchinger M | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes | Author: Yoshida I.; Ibuki Y. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: Molecular properties and the roles of repair and bypass systems | Author: Grogan D.; Jinks-Robertson S. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formation of S-[1-(N-2-Deoxyguanosinyl)methyl]glutathione between Glutathione and DNA induced formaldehyde | Author: Lu K et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro | Author: Neuss S. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies | Author: Schmid O Speit G | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxic Effects of Formaldehyde in the Human Lung Cell Line A549 and in Primary Human Nasal Epithelial Cells | Author: Speit G et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro effects of aldehydes present in tobacco smoke on gene expression 3 in human lung alveolar epithelial cells | Author: Cheah et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Investigations on potential co-mutagenic effects of formaldehyde | Author: Speit G. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Low-Dose Formaldehyde Delays DNA Damage Recognition and DNA Excision Repair in Human Cells | Author: Luch A. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Molecular analysis of formaldehyde-induced mutations in human lymphoblasts and and E. coli | Author: Crosby RM et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Protective effect of curcumin against formaldehyde-induced genotoxicity in A549 Cell Lines | Author: Zhang B-Y. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Quantitave Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N6-Formyllysine That Is Refractory to Histone Deacetylases | Author: Edrissi et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Significance of formaldehyde-induced DNA-protein crosslinks for mutagenicity | Author: Merk O Speit G | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers | Author: Lu K et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines | Author: Ren X. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Wood Dust and Formaldehyde | Author: IARC | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Ames test formaldehyde | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Ames test formaldehyde | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Analysis of Leukemia-Specific Aneuploidies in Cultured Myeloid Progenitor Cells in the Absence and Presence of Formaldehyde Exposure | Author: Kuehner S. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Benzo(a)pyrene- and formaldehyde-induced DNA damage and repair in rat tracheal epithelial cells | Author: Cosma GN & Marchok A | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: CeIls Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde | Author: Ridpath J.R. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Characterization of formaldehyde’s genotoxic mode of action by gene expression analysis in TK6 cells | Author: Kuehner S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Characterization of the genotoxic potential of formaldehyde In V79 cells | Author: Speit G et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of mutagenic effects of formaldehyde in vitro: detection of crosslinks and mutataions in mouse lymphoma cells | Author: Speit G Merk O | Year: 2002 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-nitroso-N-methylurea | Author: Grafström RC, Hsu I-H, Harris C | Year: 1993 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Re-evaluation of a reported increased micronucleus frequency in lymphocytes of workers occupationally exposed to formaldehyde | Author: Speit G et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Significance of formaldehyde-induced DNA-protein crosslinks for mutagenicity | Author: Merk O Speit G | Year: 1998 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Specific identification of formaldehyde-mediated mutagenicity using the mouse lymphoma L5178Y+/- assay supplemented with formaldehyde dehydrogenase | Author: Blackburn G et al. | Year: 1991 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Does formaldehyde induce aneuploidy? | Author: Speit G. et al. | Year: 2011 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies | Author: Schmid O Speit G | Year: 2007 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Significance of formaldehyde-induced DNA-protein crosslinks for mutagenicity | Author: Merk O Speit G | Year: 1998 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Characterization of the genotoxic potential of formaldehyde In V79 cells | Author: Speit G et al. | Year: 2007 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |