CAS 53880-05-0 | TR-REACH

Includes:

Study name	Short Description	Data Owner
Phys-Chem \| Appearance/physical state/colour	*Robust Study Summary* -- Title: Safety data sheet "Vestanat T 1890/100", Version 6.5/DE \| Author: Evonik Degussa GmbH \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane / 4098-71-9 / 223-861-6; Isophorone diisocyanate homopolymer (53880-05-0; 4098-71-9))	-
Phys-Chem \| Appearance/physical state/colour	*Right to refer to study* -- Title: Safety data sheet "Vestanat T 1890/100", Version 6.5/DE \| Author: Evonik Degussa GmbH \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane / 4098-71-9 / 223-861-6; Isophorone diisocyanate homopolymer (53880-05-0; 4098-71-9))	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 102 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Melting point/freezing point	*Right to refer to study* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 102 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Determination of the glass transition temperature of Vestanat T 1890/100 \| Author: Steinheuer A \| Year: 2002 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Phys-Chem \| Melting point/freezing point	*Right to refer to study* -- Title: Determination of the glass transition temperature of Vestanat T 1890/100 \| Author: Steinheuer A \| Year: 2002 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 103 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Boiling point	*Right to refer to study* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 103 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Determination of the relative density of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 109 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Density	*Right to refer to study* -- Title: Determination of the relative density of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 109 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Particle size distribution (Granulometry)/Fibre length and diameter distribution	Waiver	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Determination of the vapour pressure of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 104 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Vapour pressure	*Right to refer to study* -- Title: Determination of the vapour pressure of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 104 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Partition coefficient	Waiver	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Phys-Chem \| Partition coefficient	*Right to refer to study* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Phys-Chem \| Water solubility	Waiver	-
Phys-Chem \| Surface tension	Waiver	-
Phys-Chem \| Flash point	Waiver	-
Phys-Chem \| Auto-ignition temperature	Waiver	-
Phys-Chem \| Flammability	*Robust Study Summary* -- Title: Determination of the flammability of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Flammability	*Right to refer to study* -- Title: Determination of the flammability of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Explosive properties	*Robust Study Summary* -- Title: Determination of the explosion properties of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Explosive properties	*Right to refer to study* -- Title: Determination of the explosion properties of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Oxidising properties	Waiver	-
Phys-Chem \| Stability in organic solvents and identity of relevant degradation products	Waiver	-
Phys-Chem \| Stability: Dissociation constant	Waiver	-
Phys-Chem \| Viscosity	Waiver	-
Environmental \| Phototransformation in air	*Robust Study Summary* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Environmental \| Phototransformation in air	*Right to refer to study* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Environmental \| Hydrolysis	*Robust Study Summary* -- Title: Determination of the hydrolysis as a function of pH of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 111 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Hydrolysis	*Right to refer to study* -- Title: Determination of the hydrolysis as a function of pH of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 111 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Hydrolysis	*Robust Study Summary* -- Title: Determination of the hydrolysis of IPDI trimer \| Author: Feldhues E \| Year: 2007 \| Guideline: 111 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Hydrolysis	*Right to refer to study* -- Title: Determination of the hydrolysis of IPDI trimer \| Author: Feldhues E \| Year: 2007 \| Guideline: 111 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Biodegradation in water: screening tests	*Robust Study Summary* -- Title: IPDI trimer - biodegradation \| Author: Weyers A \| Year: 2007 \| Guideline: 301F \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Biodegradation in water: screening tests	*Right to refer to study* -- Title: IPDI trimer - biodegradation \| Author: Weyers A \| Year: 2007 \| Guideline: 301F \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Biodegradation in water and sediment: simulation tests	Waiver	-
Environmental \| Biodegradation in soil	Waiver	-
Environmental \| Bioaccumulation: aquatic/sediment	Waiver	-
Environmental \| Bioaccumulation: aquatic/sediment	*Robust Study Summary* -- Title: Physikalisch-chemische und Ökotoxikologische Daten von Isophorondiisocyanat, Homopolymer \| Author: Evonik Resource Efficiency GmbH, RE-ES-PS-HRA3 \| Year: 2018 \| GLP: N.	-
Environmental \| Bioaccumulation: aquatic/sediment	*Right to refer to study* -- Title: Physikalisch-chemische und Ökotoxikologische Daten von Isophorondiisocyanat, Homopolymer \| Author: Evonik Resource Efficiency GmbH, RE-ES-PS-HRA3 \| Year: 2018 \| GLP: N.	-
Environmental \| Adsorption/desorption	Waiver	-
Environmental \| Distribution modelling	Waiver	-
Environmental \| Other distribution data	Waiver	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Vestanat T 1890/100 - Determination of the acute toxicity for the fish Cyprinus carpio \| Author: Infracor GmbH \| Year: 2000 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Short-term toxicity to fish	*Right to refer to study* -- Title: Vestanat T 1890/100 - Determination of the acute toxicity for the fish Cyprinus carpio \| Author: Infracor GmbH \| Year: 2000 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Long-term toxicity to fish	Waiver	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: DESMODUR Z 4470 MPA/X Acute Immobilisation Test (48 h) to Daphnia magna STRAUS \| Author: Noack A \| Year: 2002 \| Guideline: 202 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Right to refer to study* -- Title: DESMODUR Z 4470 MPA/X Acute Immobilisation Test (48 h) to Daphnia magna STRAUS \| Author: Noack A \| Year: 2002 \| Guideline: 202 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Long-term toxicity to aquatic invertebrates	Waiver	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Robust Study Summary* -- Title: DESMODUR Z 4470 MPA/X Alga, Growth Inhibition Test with Scenedesmus subspicatus, 72 h, Limit-Test \| Author: Scheerbaum D \| Year: 2002 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Right to refer to study* -- Title: DESMODUR Z 4470 MPA/X Alga, Growth Inhibition Test with Scenedesmus subspicatus, 72 h, Limit-Test \| Author: Scheerbaum D \| Year: 2002 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Toxicity to microorganisms	*Robust Study Summary* -- Title: IPDI trimer - toxicity to bacteria \| Author: Weyers A \| Year: 2007 \| Guideline: 209 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Toxicity to microorganisms	*Right to refer to study* -- Title: IPDI trimer - toxicity to bacteria \| Author: Weyers A \| Year: 2007 \| Guideline: 209 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Sediment toxicity	Waiver	-
Eco-Tox \| Toxicity to soil macro-organisms except arthropods	Waiver	-
Eco-Tox \| Toxicity to terrestrial arthropods	Waiver	-
Eco-Tox \| Toxicity to terrestrial plants	Waiver	-
Eco-Tox \| Toxicity to soil microorganisms	Waiver	-
Eco-Tox \| Toxicity to birds	Waiver	-
Toxicological \| Basic toxicokinetics	*Robust Study Summary* -- Title: 3-Isocyanatomethyl-3,5,5-trimethyl-cyclohexyl isocyanate homopolymer (IPDI homopolymer) (CAS-Nr. 53880-05-0); Information/Assumptions regarding toxicokinetics \| Author: Kocher \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Basic toxicokinetics	*Right to refer to study* -- Title: 3-Isocyanatomethyl-3,5,5-trimethyl-cyclohexyl isocyanate homopolymer (IPDI homopolymer) (CAS-Nr. 53880-05-0); Information/Assumptions regarding toxicokinetics \| Author: Kocher \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Basic toxicokinetics	Waiver	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Akute Toxizitätsprüfung von IPDI-Addukt T 1890 nach oraler Applikation an der Ratte \| Author: IBR International Bio-Research \| Year: 1976 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: oral	*Right to refer to study* -- Title: Akute Toxizitätsprüfung von IPDI-Addukt T 1890 nach oraler Applikation an der Ratte \| Author: IBR International Bio-Research \| Year: 1976 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Akute orale Toxizität - Prüfmuster: Desmodur VP KL 5-2426 \| Author: Bayer AG \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: oral	*Right to refer to study* -- Title: Akute orale Toxizität - Prüfmuster: Desmodur VP KL 5-2426 \| Author: Bayer AG \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Vestanat T 1890/100 - study on acute inhalation toxicity in rats according to OECD 403 \| Author: Bayer AG \| Year: 1996 \| Guideline: 403 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Right to refer to study* -- Title: Vestanat T 1890/100 - study on acute inhalation toxicity in rats according to OECD 403 \| Author: Bayer AG \| Year: 1996 \| Guideline: 403 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure 1 x 6 hours) \| Author: Pauluhn J \| Year: 2003 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Right to refer to study* -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure 1 x 6 hours) \| Author: Pauluhn J \| Year: 2003 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: dermal	Waiver	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Acute dermal irritation/corrosion test (patch test) of Vestanat T 1890/100 in rabbits according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2005 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: Acute dermal irritation/corrosion test (patch test) of Vestanat T 1890/100 in rabbits according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2005 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Acute skin irritation test (patch test) of Desmodur Z 4470 MPA/X in rabbits - according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: Acute skin irritation test (patch test) of Desmodur Z 4470 MPA/X in rabbits - according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	Waiver	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Acute eye irritation study of Desmodur Z 4470 MPA/X by instillation into the conjunctival sac of rabbits - according to EC guideline B.5. and OECD guideline 405 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 405 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Acute eye irritation study of Desmodur Z 4470 MPA/X by instillation into the conjunctival sac of rabbits - according to EC guideline B.5. and OECD guideline 405 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 405 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Prüfung von IPDI-T 1890 im Augenreiztest am Kaninchen \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Prüfung von IPDI-T 1890 im Augenreiztest am Kaninchen \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	Waiver	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Desmodur Z 4470 MPA/X - local lymph node assay in mice (LLNA/IMDS) \| Author: Vohr HW \| Year: 2003 \| Guideline: 429 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Desmodur Z 4470 MPA/X - local lymph node assay in mice (LLNA/IMDS) \| Author: Vohr HW \| Year: 2003 \| Guideline: 429 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Assessment of contact hypersensitivity to Vestanat T 1890 SV in the albino guinea pig (maximisation-test) \| Author: NOTOX B.V. \| Year: 2004 \| Guideline: 406 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Assessment of contact hypersensitivity to Vestanat T 1890 SV in the albino guinea pig (maximisation-test) \| Author: NOTOX B.V. \| Year: 2004 \| Guideline: 406 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs \| Author: Zissu D, Binet S and Limasset JC \| Year: 1998 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Prüfung von "IPDI-T 1890" im epicutanen Sensibilisierungstest an der Meerschweinchenhaut (25 %ig in Sojabohnenöl) \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Prüfung von "IPDI-T 1890" im epicutanen Sensibilisierungstest an der Meerschweinchenhaut (25 %ig in Sojabohnenöl) \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: < 0,5 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: < 0,5 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: 2 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: 2 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Assessment of contact hypersensitivity to polyisocyanate resin 95222660 in the albino guinea pig (maximization test) \| Author: NOTOX B.V. \| Year: 1996 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information. Read-Across (Polyisocyanate resin 95222660)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Assessment of contact hypersensitivity to polyisocyanate resin 95222660 in the albino guinea pig (maximization test) \| Author: NOTOX B.V. \| Year: 1996 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information. Read-Across (Polyisocyanate resin 95222660)	-
Toxicological \| Skin sensitisation	Waiver	-
Toxicological \| Respiratory sensitisation	*Robust Study Summary* -- Title: Vestanat T 1890/100 - study for lung sensitization in guinea-pigs following intradermal or inhalation induction. \| Author: Bayer AG \| Year: 1996 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Respiratory sensitisation	*Right to refer to study* -- Title: Vestanat T 1890/100 - study for lung sensitization in guinea-pigs following intradermal or inhalation induction. \| Author: Bayer AG \| Year: 1996 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: oral	Waiver	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test of Desmodur XP 2565/100 by oral gavage in rats \| Author: van de Ven AWM \| Year: 2018 \| Guideline: 422 \| GLP: Y. Read-Across (CAS 933-047-9 \| 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, allophanate type (LL 105098))	-
Toxicological \| Repeated dose toxicity: oral	*Right to refer to study* -- Title: Combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test of Desmodur XP 2565/100 by oral gavage in rats \| Author: van de Ven AWM \| Year: 2018 \| Guideline: 422 \| GLP: Y. Read-Across (CAS 933-047-9 \| 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, allophanate type (LL 105098))	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: IPDI Trimer - subchronic 90-day inhalation and lung toxicity study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 413 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: IPDI Trimer - subchronic 90-day inhalation and lung toxicity study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 413 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: IPDI Trimer - subacute 14-day inhalation study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 412 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: IPDI Trimer - subacute 14-day inhalation study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 412 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Chronic inhalation toxicity and oncogenicity study with 1,6 hexamethylene diisocyanate (HDI) in rats Evaluation of nasal tract lesions in derivation of the inhalation reference concentration for hexamethylene diisocyanate \| Author: Shiotsuka RN Foureman GL \| Year: 1989 1994 \| Guideline: 453 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Chronic inhalation toxicity and oncogenicity study with 1,6 hexamethylene diisocyanate (HDI) in rats Evaluation of nasal tract lesions in derivation of the inhalation reference concentration for hexamethylene diisocyanate \| Author: Shiotsuka RN Foureman GL \| Year: 1989 1994 \| Guideline: 453 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Isophorone diisocyanate (IPDI) 90-day inhalation study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 4098-71-9 \| EC 223-861-6 \| 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Isophorone diisocyanate (IPDI) 90-day inhalation study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 4098-71-9 \| EC 223-861-6 \| 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: 90-Day Inhalation Toxicity Study with 1,6 Hexamethylene Diisocyanate (HDI) in Rats \| Author: Shiotsuka RN \| Year: 1988 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: 90-Day Inhalation Toxicity Study with 1,6 Hexamethylene Diisocyanate (HDI) in Rats \| Author: Shiotsuka RN \| Year: 1988 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Desmodur N 3300, Untersuchungen zur subchronischen Inhalationstoxizität an der Ratte nach OECD-Richtlinie No.: 413 Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: Pauluhn J Pauluhn, J. and Mohr, U. \| Year: 1987 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-274-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Desmodur N 3300, Untersuchungen zur subchronischen Inhalationstoxizität an der Ratte nach OECD-Richtlinie No.: 413 Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: Pauluhn J Pauluhn, J. and Mohr, U. \| Year: 1987 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-274-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Desmodur N 3200 Untersuchungen zur Subchronischen Inhalationstoxizitaet an der Ratte nach OECD Richtlinie No. 413 Histopathological re-evaluation of studies on subacute/subchronic inhalation toxicity in rats Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: BAYER AG BAYER AG Pauluhn, J. and Mohr, U. \| Year: 1988 2001 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 939-340-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Desmodur N 3200 Untersuchungen zur Subchronischen Inhalationstoxizitaet an der Ratte nach OECD Richtlinie No. 413 Histopathological re-evaluation of studies on subacute/subchronic inhalation toxicity in rats Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: BAYER AG BAYER AG Pauluhn, J. and Mohr, U. \| Year: 1988 2001 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 939-340-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: 90-Day Inhalation Study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: 90-Day Inhalation Study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Desmodur N 3400, 4-Week subacute inhalation study in Wistar rats \| Author: Pauluhn J \| Year: 2011 \| Guideline: 412 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-288-4 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Desmodur N 3400, 4-Week subacute inhalation study in Wistar rats \| Author: Pauluhn J \| Year: 2011 \| Guideline: 412 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-288-4 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: dermal	Waiver	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Salmonella typhimurium and Escherichia coli reverse mutation assay with Oligomerization product (isocyanurate type) of isophorone diisocyanate \| Author: Harlan CCR \| Year: 2009 \| Guideline: 471 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Right to refer to study* -- Title: Salmonella typhimurium and Escherichia coli reverse mutation assay with Oligomerization product (isocyanurate type) of isophorone diisocyanate \| Author: Harlan CCR \| Year: 2009 \| Guideline: 471 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Robust Study Summary* -- Title: Chromosomal aberration test with IPDI Trimer in cultured Chinese hamster ovary (CHO) cells \| Author: de Vogel N \| Year: 2007 \| Guideline: 473 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Right to refer to study* -- Title: Chromosomal aberration test with IPDI Trimer in cultured Chinese hamster ovary (CHO) cells \| Author: de Vogel N \| Year: 2007 \| Guideline: 473 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Robust Study Summary* -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with IPDI trimer \| Author: Schulz M and Hellwig J \| Year: 2007 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Right to refer to study* -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with IPDI trimer \| Author: Schulz M and Hellwig J \| Year: 2007 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Desmodur Z 4470 MPA/X - special study - Ames-test screening \| Author: Herbold B \| Year: 2002 \| Guideline: 471 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Right to refer to study* -- Title: Desmodur Z 4470 MPA/X - special study - Ames-test screening \| Author: Herbold B \| Year: 2002 \| Guideline: 471 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Toxicity to reproduction	Waiver	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. A combined reproduction, neonatal development, and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat \| Author: Astroff AB Astroff AB et al \| Year: 1999 2000 \| Guideline: 422 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Toxicity to reproduction	*Right to refer to study* -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. A combined reproduction, neonatal development, and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat \| Author: Astroff AB Astroff AB et al \| Year: 1999 2000 \| Guideline: 422 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproduction/Developmental Toxicity Screening Test in rats \| Author: Eiben R & Rosenbruch M \| Year: 2004 \| Guideline: 421 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Toxicity to reproduction	*Right to refer to study* -- Title: Reproduction/Developmental Toxicity Screening Test in rats \| Author: Eiben R & Rosenbruch M \| Year: 2004 \| Guideline: 421 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Developmental toxicity/teratogenicity	*Robust Study Summary* -- Title: Prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type in rats by oral administration \| Author: Laboratory of Pharmacology and Toxicology GmbH & Co. KG, Hamburg, Germany \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Developmental toxicity/teratogenicity	*Right to refer to study* -- Title: Prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type in rats by oral administration \| Author: Laboratory of Pharmacology and Toxicology GmbH & Co. KG, Hamburg, Germany \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Developmental toxicity/teratogenicity	*Robust Study Summary* -- Title: Dose-range-finding for a prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocycnate homopolymer, isocyanurate type in rats by oral administration \| Author: LPT (Laboratory of Pharmacology and Toxicology), Hamburg \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Developmental toxicity/teratogenicity	*Right to refer to study* -- Title: Dose-range-finding for a prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocycnate homopolymer, isocyanurate type in rats by oral administration \| Author: LPT (Laboratory of Pharmacology and Toxicology), Hamburg \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Developmental toxicity/teratogenicity	Waiver	-

Study name	Short Description	Data Owner
Phys-Chem \| Appearance/physical state/colour	*Robust Study Summary* -- Title: Safety data sheet "Vestanat T 1890/100", Version 6.5/DE \| Author: Evonik Degussa GmbH \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane / 4098-71-9 / 223-861-6; Isophorone diisocyanate homopolymer (53880-05-0; 4098-71-9))	-
Phys-Chem \| Appearance/physical state/colour	*Right to refer to study* -- Title: Safety data sheet "Vestanat T 1890/100", Version 6.5/DE \| Author: Evonik Degussa GmbH \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane / 4098-71-9 / 223-861-6; Isophorone diisocyanate homopolymer (53880-05-0; 4098-71-9))	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 102 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Melting point/freezing point	*Right to refer to study* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 102 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Melting point/freezing point	*Robust Study Summary* -- Title: Determination of the glass transition temperature of Vestanat T 1890/100 \| Author: Steinheuer A \| Year: 2002 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Phys-Chem \| Melting point/freezing point	*Right to refer to study* -- Title: Determination of the glass transition temperature of Vestanat T 1890/100 \| Author: Steinheuer A \| Year: 2002 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: N.	-
Phys-Chem \| Boiling point	*Robust Study Summary* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 103 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Boiling point	*Right to refer to study* -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 103 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Density	*Robust Study Summary* -- Title: Determination of the relative density of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 109 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Density	*Right to refer to study* -- Title: Determination of the relative density of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 109 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Particle size distribution (Granulometry)/Fibre length and diameter distribution	Waiver	-
Phys-Chem \| Vapour pressure	*Robust Study Summary* -- Title: Determination of the vapour pressure of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 104 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Vapour pressure	*Right to refer to study* -- Title: Determination of the vapour pressure of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 104 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Partition coefficient	Waiver	-
Phys-Chem \| Partition coefficient	*Robust Study Summary* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Phys-Chem \| Partition coefficient	*Right to refer to study* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Phys-Chem \| Water solubility	Waiver	-
Phys-Chem \| Surface tension	Waiver	-
Phys-Chem \| Flash point	Waiver	-
Phys-Chem \| Auto-ignition temperature	Waiver	-
Phys-Chem \| Flammability	*Robust Study Summary* -- Title: Determination of the flammability of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Flammability	*Right to refer to study* -- Title: Determination of the flammability of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Explosive properties	*Robust Study Summary* -- Title: Determination of the explosion properties of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Explosive properties	*Right to refer to study* -- Title: Determination of the explosion properties of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2009 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Phys-Chem \| Oxidising properties	Waiver	-
Phys-Chem \| Stability in organic solvents and identity of relevant degradation products	Waiver	-
Phys-Chem \| Stability: Dissociation constant	Waiver	-
Phys-Chem \| Viscosity	Waiver	-
Environmental \| Phototransformation in air	*Robust Study Summary* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Environmental \| Phototransformation in air	*Right to refer to study* -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat, Homopolymer \| Author: Evonik Degussa GmbH \| Year: 2005 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study. Read-Across (CAS 67873-91-0 \| EC 267-445-2 \| 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione)	-
Environmental \| Hydrolysis	*Robust Study Summary* -- Title: Determination of the hydrolysis as a function of pH of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 111 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Hydrolysis	*Right to refer to study* -- Title: Determination of the hydrolysis as a function of pH of Vestanat T 1890/100 \| Author: AQura GmbH \| Year: 2010 \| Guideline: 111 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Hydrolysis	*Robust Study Summary* -- Title: Determination of the hydrolysis of IPDI trimer \| Author: Feldhues E \| Year: 2007 \| Guideline: 111 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Hydrolysis	*Right to refer to study* -- Title: Determination of the hydrolysis of IPDI trimer \| Author: Feldhues E \| Year: 2007 \| Guideline: 111 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Biodegradation in water: screening tests	*Robust Study Summary* -- Title: IPDI trimer - biodegradation \| Author: Weyers A \| Year: 2007 \| Guideline: 301F \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Biodegradation in water: screening tests	*Right to refer to study* -- Title: IPDI trimer - biodegradation \| Author: Weyers A \| Year: 2007 \| Guideline: 301F \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Environmental \| Biodegradation in water and sediment: simulation tests	Waiver	-
Environmental \| Biodegradation in soil	Waiver	-
Environmental \| Bioaccumulation: aquatic/sediment	Waiver	-
Environmental \| Bioaccumulation: aquatic/sediment	*Robust Study Summary* -- Title: Physikalisch-chemische und Ökotoxikologische Daten von Isophorondiisocyanat, Homopolymer \| Author: Evonik Resource Efficiency GmbH, RE-ES-PS-HRA3 \| Year: 2018 \| GLP: N.	-
Environmental \| Bioaccumulation: aquatic/sediment	*Right to refer to study* -- Title: Physikalisch-chemische und Ökotoxikologische Daten von Isophorondiisocyanat, Homopolymer \| Author: Evonik Resource Efficiency GmbH, RE-ES-PS-HRA3 \| Year: 2018 \| GLP: N.	-
Environmental \| Adsorption/desorption	Waiver	-
Environmental \| Distribution modelling	Waiver	-
Environmental \| Other distribution data	Waiver	-
Eco-Tox \| Short-term toxicity to fish	*Robust Study Summary* -- Title: Vestanat T 1890/100 - Determination of the acute toxicity for the fish Cyprinus carpio \| Author: Infracor GmbH \| Year: 2000 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Short-term toxicity to fish	*Right to refer to study* -- Title: Vestanat T 1890/100 - Determination of the acute toxicity for the fish Cyprinus carpio \| Author: Infracor GmbH \| Year: 2000 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Long-term toxicity to fish	Waiver	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Robust Study Summary* -- Title: DESMODUR Z 4470 MPA/X Acute Immobilisation Test (48 h) to Daphnia magna STRAUS \| Author: Noack A \| Year: 2002 \| Guideline: 202 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Short-term toxicity to aquatic invertebrates	*Right to refer to study* -- Title: DESMODUR Z 4470 MPA/X Acute Immobilisation Test (48 h) to Daphnia magna STRAUS \| Author: Noack A \| Year: 2002 \| Guideline: 202 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Long-term toxicity to aquatic invertebrates	Waiver	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Robust Study Summary* -- Title: DESMODUR Z 4470 MPA/X Alga, Growth Inhibition Test with Scenedesmus subspicatus, 72 h, Limit-Test \| Author: Scheerbaum D \| Year: 2002 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Toxicity to aquatic algae and cyanobacteria	*Right to refer to study* -- Title: DESMODUR Z 4470 MPA/X Alga, Growth Inhibition Test with Scenedesmus subspicatus, 72 h, Limit-Test \| Author: Scheerbaum D \| Year: 2002 \| Guideline: 201 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Toxicity to microorganisms	*Robust Study Summary* -- Title: IPDI trimer - toxicity to bacteria \| Author: Weyers A \| Year: 2007 \| Guideline: 209 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Toxicity to microorganisms	*Right to refer to study* -- Title: IPDI trimer - toxicity to bacteria \| Author: Weyers A \| Year: 2007 \| Guideline: 209 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Eco-Tox \| Sediment toxicity	Waiver	-
Eco-Tox \| Toxicity to soil macro-organisms except arthropods	Waiver	-
Eco-Tox \| Toxicity to terrestrial arthropods	Waiver	-
Eco-Tox \| Toxicity to terrestrial plants	Waiver	-
Eco-Tox \| Toxicity to soil microorganisms	Waiver	-
Eco-Tox \| Toxicity to birds	Waiver	-
Toxicological \| Basic toxicokinetics	*Robust Study Summary* -- Title: 3-Isocyanatomethyl-3,5,5-trimethyl-cyclohexyl isocyanate homopolymer (IPDI homopolymer) (CAS-Nr. 53880-05-0); Information/Assumptions regarding toxicokinetics \| Author: Kocher \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Basic toxicokinetics	*Right to refer to study* -- Title: 3-Isocyanatomethyl-3,5,5-trimethyl-cyclohexyl isocyanate homopolymer (IPDI homopolymer) (CAS-Nr. 53880-05-0); Information/Assumptions regarding toxicokinetics \| Author: Kocher \| Year: 2009 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Basic toxicokinetics	Waiver	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Akute Toxizitätsprüfung von IPDI-Addukt T 1890 nach oraler Applikation an der Ratte \| Author: IBR International Bio-Research \| Year: 1976 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: oral	*Right to refer to study* -- Title: Akute Toxizitätsprüfung von IPDI-Addukt T 1890 nach oraler Applikation an der Ratte \| Author: IBR International Bio-Research \| Year: 1976 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: key study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: oral	*Robust Study Summary* -- Title: Akute orale Toxizität - Prüfmuster: Desmodur VP KL 5-2426 \| Author: Bayer AG \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: oral	*Right to refer to study* -- Title: Akute orale Toxizität - Prüfmuster: Desmodur VP KL 5-2426 \| Author: Bayer AG \| Year: 1978 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Vestanat T 1890/100 - study on acute inhalation toxicity in rats according to OECD 403 \| Author: Bayer AG \| Year: 1996 \| Guideline: 403 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Right to refer to study* -- Title: Vestanat T 1890/100 - study on acute inhalation toxicity in rats according to OECD 403 \| Author: Bayer AG \| Year: 1996 \| Guideline: 403 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Robust Study Summary* -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure 1 x 6 hours) \| Author: Pauluhn J \| Year: 2003 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: inhalation	*Right to refer to study* -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure 1 x 6 hours) \| Author: Pauluhn J \| Year: 2003 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Acute toxicity: dermal	Waiver	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Acute dermal irritation/corrosion test (patch test) of Vestanat T 1890/100 in rabbits according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2005 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: Acute dermal irritation/corrosion test (patch test) of Vestanat T 1890/100 in rabbits according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2005 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Acute skin irritation test (patch test) of Desmodur Z 4470 MPA/X in rabbits - according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: Acute skin irritation test (patch test) of Desmodur Z 4470 MPA/X in rabbits - according to EC guideline B.4. and OECD guideline 404 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 404 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin irritation / corrosion	*Robust Study Summary* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	*Right to refer to study* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin irritation / corrosion	Waiver	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Acute eye irritation study of Desmodur Z 4470 MPA/X by instillation into the conjunctival sac of rabbits - according to EC guideline B.5. and OECD guideline 405 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 405 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Acute eye irritation study of Desmodur Z 4470 MPA/X by instillation into the conjunctival sac of rabbits - according to EC guideline B.5. and OECD guideline 405 \| Author: LPT (Laboratory of Pharmacology and Toxicology) \| Year: 2002 \| Guideline: 405 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Prüfung von IPDI-T 1890 im Augenreiztest am Kaninchen \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Prüfung von IPDI-T 1890 im Augenreiztest am Kaninchen \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Eye irritation	*Robust Study Summary* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	*Right to refer to study* -- Title: Untersuchung zur Haut- und Schleimhautverträglichkeit - Prüfmuster: Desmodur VPKL 5-2426 \| Author: Thyssen J \| Year: 1978 \| Klimisch score: 4 - Not assignable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Eye irritation	Waiver	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Desmodur Z 4470 MPA/X - local lymph node assay in mice (LLNA/IMDS) \| Author: Vohr HW \| Year: 2003 \| Guideline: 429 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Desmodur Z 4470 MPA/X - local lymph node assay in mice (LLNA/IMDS) \| Author: Vohr HW \| Year: 2003 \| Guideline: 429 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Assessment of contact hypersensitivity to Vestanat T 1890 SV in the albino guinea pig (maximisation-test) \| Author: NOTOX B.V. \| Year: 2004 \| Guideline: 406 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Assessment of contact hypersensitivity to Vestanat T 1890 SV in the albino guinea pig (maximisation-test) \| Author: NOTOX B.V. \| Year: 2004 \| Guideline: 406 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs \| Author: Zissu D, Binet S and Limasset JC \| Year: 1998 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Prüfung von "IPDI-T 1890" im epicutanen Sensibilisierungstest an der Meerschweinchenhaut (25 %ig in Sojabohnenöl) \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Prüfung von "IPDI-T 1890" im epicutanen Sensibilisierungstest an der Meerschweinchenhaut (25 %ig in Sojabohnenöl) \| Author: IBR International Bio-Research \| Year: 1977 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: N. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: < 0,5 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: < 0,5 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: 2 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Polyisocyanat IPDI-T 1890S (monomeres IPDI: 2 Gew. %) - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) \| Author: IBR International Bio-Research \| Year: 1983 \| Guideline: 406 \| Klimisch score: 3 - Not reliable \| Adequacy: other information \| GLP: N.	-
Toxicological \| Skin sensitisation	*Robust Study Summary* -- Title: Assessment of contact hypersensitivity to polyisocyanate resin 95222660 in the albino guinea pig (maximization test) \| Author: NOTOX B.V. \| Year: 1996 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information. Read-Across (Polyisocyanate resin 95222660)	-
Toxicological \| Skin sensitisation	*Right to refer to study* -- Title: Assessment of contact hypersensitivity to polyisocyanate resin 95222660 in the albino guinea pig (maximization test) \| Author: NOTOX B.V. \| Year: 1996 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information. Read-Across (Polyisocyanate resin 95222660)	-
Toxicological \| Skin sensitisation	Waiver	-
Toxicological \| Respiratory sensitisation	*Robust Study Summary* -- Title: Vestanat T 1890/100 - study for lung sensitization in guinea-pigs following intradermal or inhalation induction. \| Author: Bayer AG \| Year: 1996 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Respiratory sensitisation	*Right to refer to study* -- Title: Vestanat T 1890/100 - study for lung sensitization in guinea-pigs following intradermal or inhalation induction. \| Author: Bayer AG \| Year: 1996 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: oral	Waiver	-
Toxicological \| Repeated dose toxicity: oral	*Robust Study Summary* -- Title: Combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test of Desmodur XP 2565/100 by oral gavage in rats \| Author: van de Ven AWM \| Year: 2018 \| Guideline: 422 \| GLP: Y. Read-Across (CAS 933-047-9 \| 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, allophanate type (LL 105098))	-
Toxicological \| Repeated dose toxicity: oral	*Right to refer to study* -- Title: Combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test of Desmodur XP 2565/100 by oral gavage in rats \| Author: van de Ven AWM \| Year: 2018 \| Guideline: 422 \| GLP: Y. Read-Across (CAS 933-047-9 \| 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, allophanate type (LL 105098))	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: IPDI Trimer - subchronic 90-day inhalation and lung toxicity study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 413 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: IPDI Trimer - subchronic 90-day inhalation and lung toxicity study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 413 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: IPDI Trimer - subacute 14-day inhalation study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 412 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: IPDI Trimer - subacute 14-day inhalation study in Wistar rats - dust aerosol exposure \| Author: Ma-Hock L, Strauss V, Kaufmann W and van Ravenzwaay B \| Year: 2009 \| Guideline: 412 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Chronic inhalation toxicity and oncogenicity study with 1,6 hexamethylene diisocyanate (HDI) in rats Evaluation of nasal tract lesions in derivation of the inhalation reference concentration for hexamethylene diisocyanate \| Author: Shiotsuka RN Foureman GL \| Year: 1989 1994 \| Guideline: 453 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Chronic inhalation toxicity and oncogenicity study with 1,6 hexamethylene diisocyanate (HDI) in rats Evaluation of nasal tract lesions in derivation of the inhalation reference concentration for hexamethylene diisocyanate \| Author: Shiotsuka RN Foureman GL \| Year: 1989 1994 \| Guideline: 453 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Isophorone diisocyanate (IPDI) 90-day inhalation study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 4098-71-9 \| EC 223-861-6 \| 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Isophorone diisocyanate (IPDI) 90-day inhalation study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 4098-71-9 \| EC 223-861-6 \| 5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: 90-Day Inhalation Toxicity Study with 1,6 Hexamethylene Diisocyanate (HDI) in Rats \| Author: Shiotsuka RN \| Year: 1988 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: 90-Day Inhalation Toxicity Study with 1,6 Hexamethylene Diisocyanate (HDI) in Rats \| Author: Shiotsuka RN \| Year: 1988 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Desmodur N 3300, Untersuchungen zur subchronischen Inhalationstoxizität an der Ratte nach OECD-Richtlinie No.: 413 Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: Pauluhn J Pauluhn, J. and Mohr, U. \| Year: 1987 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-274-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Desmodur N 3300, Untersuchungen zur subchronischen Inhalationstoxizität an der Ratte nach OECD-Richtlinie No.: 413 Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: Pauluhn J Pauluhn, J. and Mohr, U. \| Year: 1987 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-274-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Desmodur N 3200 Untersuchungen zur Subchronischen Inhalationstoxizitaet an der Ratte nach OECD Richtlinie No. 413 Histopathological re-evaluation of studies on subacute/subchronic inhalation toxicity in rats Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: BAYER AG BAYER AG Pauluhn, J. and Mohr, U. \| Year: 1988 2001 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 939-340-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Desmodur N 3200 Untersuchungen zur Subchronischen Inhalationstoxizitaet an der Ratte nach OECD Richtlinie No. 413 Histopathological re-evaluation of studies on subacute/subchronic inhalation toxicity in rats Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymers (HDI-IC and HDI-BT): Results of Subacute and Subchronic Repeated Inhalation Exposure Studies \| Author: BAYER AG BAYER AG Pauluhn, J. and Mohr, U. \| Year: 1988 2001 2001 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 939-340-8 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: 90-Day Inhalation Study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: 90-Day Inhalation Study with a 4-week recovery period in Wistar rats \| Author: Pauluhn J \| Year: 2008 \| Guideline: 413 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Repeated dose toxicity: inhalation	*Robust Study Summary* -- Title: Desmodur N 3400, 4-Week subacute inhalation study in Wistar rats \| Author: Pauluhn J \| Year: 2011 \| Guideline: 412 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-288-4 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: inhalation	*Right to refer to study* -- Title: Desmodur N 3400, 4-Week subacute inhalation study in Wistar rats \| Author: Pauluhn J \| Year: 2011 \| Guideline: 412 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: other information \| GLP: Y. Read-Across (CAS 28182-81-2 \| EC 931-288-4 \| Hexamethylene diisocyanate, oligomers)	-
Toxicological \| Repeated dose toxicity: dermal	Waiver	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Salmonella typhimurium and Escherichia coli reverse mutation assay with Oligomerization product (isocyanurate type) of isophorone diisocyanate \| Author: Harlan CCR \| Year: 2009 \| Guideline: 471 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Right to refer to study* -- Title: Salmonella typhimurium and Escherichia coli reverse mutation assay with Oligomerization product (isocyanurate type) of isophorone diisocyanate \| Author: Harlan CCR \| Year: 2009 \| Guideline: 471 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Robust Study Summary* -- Title: Chromosomal aberration test with IPDI Trimer in cultured Chinese hamster ovary (CHO) cells \| Author: de Vogel N \| Year: 2007 \| Guideline: 473 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro cytogenicity study in mammalian cells (CA)	*Right to refer to study* -- Title: Chromosomal aberration test with IPDI Trimer in cultured Chinese hamster ovary (CHO) cells \| Author: de Vogel N \| Year: 2007 \| Guideline: 473 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Robust Study Summary* -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with IPDI trimer \| Author: Schulz M and Hellwig J \| Year: 2007 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in mammalian cells	*Right to refer to study* -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with IPDI trimer \| Author: Schulz M and Hellwig J \| Year: 2007 \| Guideline: 476 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Robust Study Summary* -- Title: Desmodur Z 4470 MPA/X - special study - Ames-test screening \| Author: Herbold B \| Year: 2002 \| Guideline: 471 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| in vitro gene mutation study in bacteria (Ames)	*Right to refer to study* -- Title: Desmodur Z 4470 MPA/X - special study - Ames-test screening \| Author: Herbold B \| Year: 2002 \| Guideline: 471 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: supporting study \| GLP: Y. Read-Across (3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer / 53880-05-0 / 500-125-5; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type 931-312-3 / 53880-05-0)	-
Toxicological \| Toxicity to reproduction	Waiver	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. A combined reproduction, neonatal development, and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat \| Author: Astroff AB Astroff AB et al \| Year: 1999 2000 \| Guideline: 422 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Toxicity to reproduction	*Right to refer to study* -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. A combined reproduction, neonatal development, and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat \| Author: Astroff AB Astroff AB et al \| Year: 1999 2000 \| Guideline: 422 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 822-06-0 \| EC 212-485-8 \| 1,6-diisocyanatohexane)	-
Toxicological \| Toxicity to reproduction	*Robust Study Summary* -- Title: Reproduction/Developmental Toxicity Screening Test in rats \| Author: Eiben R & Rosenbruch M \| Year: 2004 \| Guideline: 421 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Toxicity to reproduction	*Right to refer to study* -- Title: Reproduction/Developmental Toxicity Screening Test in rats \| Author: Eiben R & Rosenbruch M \| Year: 2004 \| Guideline: 421 \| Klimisch score: 2 - Reliable with restrictions \| Adequacy: weight of evidence \| GLP: Y. Read-Across (CAS 5124-30-1 \| EC 225-863-2 \| 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane)	-
Toxicological \| Developmental toxicity/teratogenicity	*Robust Study Summary* -- Title: Prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type in rats by oral administration \| Author: Laboratory of Pharmacology and Toxicology GmbH & Co. KG, Hamburg, Germany \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Developmental toxicity/teratogenicity	*Right to refer to study* -- Title: Prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate homopolymer, isocyanurate type in rats by oral administration \| Author: Laboratory of Pharmacology and Toxicology GmbH & Co. KG, Hamburg, Germany \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: key study \| GLP: Y.	-
Toxicological \| Developmental toxicity/teratogenicity	*Robust Study Summary* -- Title: Dose-range-finding for a prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocycnate homopolymer, isocyanurate type in rats by oral administration \| Author: LPT (Laboratory of Pharmacology and Toxicology), Hamburg \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Developmental toxicity/teratogenicity	*Right to refer to study* -- Title: Dose-range-finding for a prenatal developmental toxicity study of 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocycnate homopolymer, isocyanurate type in rats by oral administration \| Author: LPT (Laboratory of Pharmacology and Toxicology), Hamburg \| Year: 2017 \| Guideline: 414 \| Klimisch score: 1 - Reliable without restriction \| Adequacy: supporting study \| GLP: N.	-
Toxicological \| Developmental toxicity/teratogenicity	Waiver	-

CAS 53880-05-0 | Data Package > 1000 t/a

Includes: