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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index. An encyclopedia of chemicals drugs and biologicals. | Author: O'Neil M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: The Merck Index. An encyclopedia of chemicals drugs and biologicals. | Author: O'Neil M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. | Author: O'Neil M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. | Author: O'Neil M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Handbook of Dataon Organic Compounds 2nd. Ed. | Author: Weast R.C. Grasselli J.G. eds. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Handbook of Dataon Organic Compounds 2nd. Ed. | Author: Weast R.C. Grasselli J.G. eds. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physical Properties Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Physical Properties Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Methylpolysiloxanes. | Author: Patnode W. Wilcock D.F. | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Methylpolysiloxanes. | Author: Patnode W. Wilcock D.F. | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Encyclopedia of Chemical Technology 3rd ed. | Author: Kirk-Othmer | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Encyclopedia of Chemical Technology 3rd ed. | Author: Kirk-Othmer | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Organo- Silicon Polymers. The Cyclic Dimethyl|Siloxanes. | Author: Hunter M.J. Hyde J.F. Warrick E.L. Fletcher H.J.| | Year: 1946 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Organo- Silicon Polymers. The Cyclic Dimethyl|Siloxanes. | Author: Hunter M.J. Hyde J.F. Warrick E.L. Fletcher H.J.| | Year: 1946 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Vapor Pressure of Pure Substances. | Author: Stull D.R. | Year: 1947 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Vapor Pressure of Pure Substances. | Author: Stull D.R. | Year: 1947 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. | Author: O'Neil M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. | Author: O'Neil M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of Data on Organic Compounds 2nd. Ed. | Author: Weast R.C. Grasselli J.G. eds. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Handbook of Data on Organic Compounds 2nd. Ed. | Author: Weast R.C. Grasselli J.G. eds. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Physical Properties Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Physical Properties Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Vapor Pressures of Poly(dimethylsiloxane) Oligomers. | Author: Flaningam O.L. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Vapor Pressures of Poly(dimethylsiloxane) Oligomers. | Author: Flaningam O.L. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Vapor Liquid Critical Properties. A Supplement to Report Chem. 107 | Author: Ambrose D. | Year: 1983 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Vapor Liquid Critical Properties. A Supplement to Report Chem. 107 | Author: Ambrose D. | Year: 1983 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Raman Spectra of Low Molecular Weight Siloxanes. | Author: Slobodin Ya.M. Shmulyakovskii Ya.E. Rzhedzinsdaya K.A. | Year: 1955 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Raman Spectra of Low Molecular Weight Siloxanes. | Author: Slobodin Ya.M. Shmulyakovskii Ya.E. Rzhedzinsdaya K.A. | Year: 1955 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Encyclopedia of Chemical Technology 3rd ed. | Author: Kirk-Othmer | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Encyclopedia of Chemical Technology 3rd ed. | Author: Kirk-Othmer | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Saturated Vapor Pressures of|Polydiorganosiloxanes II. Polydimethylcyclosiloxanes. | Author: Ditsent V.E. Skorokhodov I.I. Terent'eva N.A. Zolotareva M.N. | Year: 1971 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Saturated Vapor Pressures of|Polydiorganosiloxanes II. Polydimethylcyclosiloxanes. | Author: Ditsent V.E. Skorokhodov I.I. Terent'eva N.A. Zolotareva M.N. | Year: 1971 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Methylpolysiloxanes. | Author: Patnode W. Wilcock D.F. | Year: 1946 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Methylpolysiloxanes. | Author: Patnode W. Wilcock D.F. | Year: 1946 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. Twelfth Edition. | Author: Merck | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. Twelfth Edition. | Author: Merck | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physical Properties Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Physical Properties Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Handbook of Environmental Chemistry: Organosilicon Materials. | Author: Chandra G. Ed. | Year: 1997 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: The Handbook of Environmental Chemistry: Organosilicon Materials. | Author: Chandra G. Ed. | Year: 1997 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical Property Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Physical Property Database | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Measurement of Thermophysical Pure Component Properties for a Fee Siloxanes Used as Working Fluids for Organic Rankine Cycles | Author: Abbas R Schedemann A Ihmels C Enders S Gmehling J | Year: 2011 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Measurement of Thermophysical Pure Component Properties for a Fee Siloxanes Used as Working Fluids for Organic Rankine Cycles | Author: Abbas R Schedemann A Ihmels C Enders S Gmehling J | Year: 2011 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Temperature-Dependent Vapor Pressure of Selected Cyclic and Linear Polydimethylsiloxane Oligomers | Author: Lei Y D Wania F Mathers D | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Temperature-Dependent Vapor Pressure of Selected Cyclic and Linear Polydimethylsiloxane Oligomers | Author: Lei Y D Wania F Mathers D | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapour pressure of poly(dimethylsiloxane) oligomers. | Author: Flaningam O L | Year: 1986 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapour pressure of poly(dimethylsiloxane) oligomers. | Author: Flaningam O L | Year: 1986 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapour pressure of poly(dimethylsiloxane) oligomers. | Author: Flaningam O.L. | Year: 1986 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapour pressure of poly(dimethylsiloxane) oligomers. | Author: Flaningam O.L. | Year: 1986 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Organosilicon materials. | Author: Chandra G | Year: 1997 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Organosilicon materials. | Author: Chandra G | Year: 1997 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. Twelfth Edition. | Author: Merck | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: The MERCK Index. An encyclopedia of chemicals drugs and biologicals. Twelfth Edition. | Author: Merck | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Distribution modelling | Right to refer to study -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Aqueous Solubility of Permethylsiloxanes (Silicones). | Author: Varaprath S.; Frye C.; Hamelink J. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Aqueous Solubility of Permethylsiloxanes (Silicones). | Author: Varaprath S.; Frye C.; Hamelink J. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Xu S Kropscott B | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Xu S Kropscott B | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethylcyclopentasiloxane (D5) by the Slow-Stirring Method Using Gas Chromogratography and Mass Spectrometry. | Author: Kozerski G E Shawl H R | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethylcyclopentasiloxane (D5) by the Slow-Stirring Method Using Gas Chromogratography and Mass Spectrometry. | Author: Kozerski G E Shawl H R | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethylcyclopentasiloxane (d5) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethylcyclopentasiloxane (d5) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: 1-Octanol/Air Partitioning Coefficients of Octamethylcyclotetrasiloxane (D4) Decamethylcyclopentasiloxane (D5) and Dodecamethylcyclohexasiloxane (D6) at Different Temperatures. | Author: Xu S | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: 1-Octanol/Air Partitioning Coefficients of Octamethylcyclotetrasiloxane (D4) Decamethylcyclopentasiloxane (D5) and Dodecamethylcyclohexasiloxane (D6) at Different Temperatures. | Author: Xu S | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: QMRF for the prediction of the viscosity of chlorosilanes from boiling point | Author: Peter Fisk Associates | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: QMRF for the prediction of the viscosity of chlorosilanes from boiling point | Author: Peter Fisk Associates | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: QPRF for prediction of the viscosity of methoxysilanes from boiling point | Author: Peter Fisk Associates | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: QPRF for prediction of the viscosity of methoxysilanes from boiling point | Author: Peter Fisk Associates | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Research Chemicals and Metals | Author: AbCR | Year: 1991 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Research Chemicals and Metals | Author: AbCR | Year: 1991 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Organosilicon materials. | Author: Mazzoni S. M. et al | Year: 1997 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Organosilicon materials. | Author: Mazzoni S. M. et al | Year: 1997 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Flash Point Autoignition Temperature and Lower and Upper Flammability Limits of Selected Silicon Intermediates-II. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Flash Point Autoignition Temperature and Lower and Upper Flammability Limits of Selected Silicon Intermediates-II. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flash Point Autoignition Temperature and Lower and Upper Flammability Limits of Selected Silicon Intermediates-II. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flash Point Autoignition Temperature and Lower and Upper Flammability Limits of Selected Silicon Intermediates-II. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Process Safety Test Results and Interpretation for Decamethylcyclopentasiloxane 97% | Author: Chilworth Technology Inc. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Process Safety Test Results and Interpretation for Decamethylcyclopentasiloxane 97% | Author: Chilworth Technology Inc. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Safety Data Sheet | Author: Bayer AG | Year: 2004 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Safety Data Sheet | Author: Bayer AG | Year: 2004 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Flash Point Autoignition Temperature and Lower and Upper Flammability Limits of Selected Silicon Intermediates-II. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Flash Point Autoignition Temperature and Lower and Upper Flammability Limits of Selected Silicon Intermediates-II. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation study. | Author: Toxikon Corporation | Year: 1990 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation study. | Author: Toxikon Corporation | Year: 1990 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Rabbit skin irritation (closed patch test) | Author: Proctor & Gamble | Year: 1985 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Rabbit skin irritation (closed patch test) | Author: Proctor & Gamble | Year: 1985 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Rabbit Skin Irritation (SL: V3948-107) | Author: Unknown | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Rabbit Skin Irritation (SL: V3948-107) | Author: Unknown | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Pr??fung auf prim??r reizende Wirkung an der Kaninchenhaut (Baysilone-??l VP AC 3060) | Author: Bayer AG | Year: 1983 | Guideline: 404 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Pr??fung auf prim??r reizende Wirkung an der Kaninchenhaut (Baysilone-??l VP AC 3060) | Author: Bayer AG | Year: 1983 | Guideline: 404 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary ocular irritation. | Author: Toxikon Corporation | Year: 1990 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary ocular irritation. | Author: Toxikon Corporation | Year: 1990 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Draize eye irritation of the test material T7095 in rabbits | Author: Springborn Institute for Bioresearch Inc | Year: 1977 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Draize eye irritation of the test material T7095 in rabbits | Author: Springborn Institute for Bioresearch Inc | Year: 1977 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Miscellaneous Toxicity Studies | Author: Carnegie-Mellon | Year: 1976 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Miscellaneous Toxicity Studies | Author: Carnegie-Mellon | Year: 1976 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pr??fung auf prim??r reizende Wirkung an der Kaninchenhaut (Baysilone-??l VP AC 3060) | Author: Bayer AG | Year: 1983 | Guideline: 405 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Pr??fung auf prim??r reizende Wirkung an der Kaninchenhaut (Baysilone-??l VP AC 3060) | Author: Bayer AG | Year: 1983 | Guideline: 405 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pr??fung auf prim??r reizende/??tzende Wirkung am Kaninchenauge (Baysilone-??l VP AC 3060) | Author: Suberg H | Year: 1983 | Guideline: 405 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Pr??fung auf prim??r reizende/??tzende Wirkung am Kaninchenauge (Baysilone-??l VP AC 3060) | Author: Suberg H | Year: 1983 | Guideline: 405 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Test for sensitisation (Local Lymph Node Assay - LLNA) with 1111-19-372 | Author: BSL Bioservice Scientific Labs | Year: 2005 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (87% 541-02-6 and 13% 443892-05-5; 87% Decamethylcyc1opentasiloxane 13% Silicone Gel) |
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| Toxicological | Skin sensitisation | Right to refer to study -- Title: Test for sensitisation (Local Lymph Node Assay - LLNA) with 1111-19-372 | Author: BSL Bioservice Scientific Labs | Year: 2005 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (87% 541-02-6 and 13% 443892-05-5; 87% Decamethylcyc1opentasiloxane 13% Silicone Gel) |
- |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Kligman maximisation test - modified | Author: Toxikon Corporation | Year: 1998 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Kligman maximisation test - modified | Author: Toxikon Corporation | Year: 1998 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Kligman maximisation test - modified | Author: Toxikon Corporation | Year: 1998 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Kligman maximisation test - modified | Author: Toxikon Corporation | Year: 1998 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Buehler Topical Closed Patch Technique | Author: Toxikon Corporation | Year: 1990 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Buehler Topical Closed Patch Technique | Author: Toxikon Corporation | Year: 1990 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Pr??fung auf sensibilisierende Wirkung ander Meerschweinchenhaut. | Author: Bayer AG | Year: 1985 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Pr??fung auf sensibilisierende Wirkung ander Meerschweinchenhaut. | Author: Bayer AG | Year: 1985 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella typhimurium and Escherichia coli Reverse Mutation Assay with Decamethylcyclopentasiloxane (D5) | Author: RCC Cytotest cell research | Year: 2003 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella typhimurium and Escherichia coli Reverse Mutation Assay with Decamethylcyclopentasiloxane (D5) | Author: RCC Cytotest cell research | Year: 2003 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro Chromosome Aberration Test in Chinese Hamster V79 Cells with Decamethylcyclopentasiloxane (D5) | Author: Dow Corning Corporation | Year: 2003 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro Chromosome Aberration Test in Chinese Hamster V79 Cells with Decamethylcyclopentasiloxane (D5) | Author: Dow Corning Corporation | Year: 2003 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: studies on selected organosilicon compounds: in vitro assays | Author: Isquith A et al. | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: studies on selected organosilicon compounds: in vitro assays | Author: Isquith A et al. | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella/Microsomen Test zur Untersuchung auf Punktmutagene Wirkung | Author: Bayer | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella/Microsomen Test zur Untersuchung auf Punktmutagene Wirkung | Author: Bayer | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity Evaluation of Dow Corning 345 Fluid in the Ames Bacterial Assay. | Author: Dow Corning Corporation | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenicity Evaluation of Dow Corning 345 Fluid in the Ames Bacterial Assay. | Author: Dow Corning Corporation | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane (Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays | Author: Isquith A et al. | Year: 1988 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays | Author: Isquith A et al. | Year: 1988 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane|(Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Mutagenicity Evaluation of Decamethylcyclopentasiloxane|(Me2SiO)5 Final Report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Analysis of the Genotoxic Potential of Decamethylcyclopentasiloxane (D5) of Fischer 344 Rats Following Whole Body Vapor Inhalation for 7 Days. | Author: RCC Cytotest cell research | Year: 2004 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Analysis of the Genotoxic Potential of Decamethylcyclopentasiloxane (D5) of Fischer 344 Rats Following Whole Body Vapor Inhalation for 7 Days. | Author: RCC Cytotest cell research | Year: 2004 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Analysis of the Genotoxic Potential of Decamethylcyclopentasiloxane (D5) if Fischer 344 Rats Following Whole Body Vapor Inhalation for 7 Days. | Author: RCC Cytotest cell research | Year: 2004 | Guideline: 486 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Analysis of the Genotoxic Potential of Decamethylcyclopentasiloxane (D5) if Fischer 344 Rats Following Whole Body Vapor Inhalation for 7 Days. | Author: RCC Cytotest cell research | Year: 2004 | Guideline: 486 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute oral toxicity | Author: Toxikon Corporation | Year: 1990 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute oral toxicity | Author: Toxikon Corporation | Year: 1990 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: A study of the acute oral (LD50) toxicity of the test substance T7095 in rats | Author: Springborn Institute for Bioresearch Inc | Year: 1977 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: A study of the acute oral (LD50) toxicity of the test substance T7095 in rats | Author: Springborn Institute for Bioresearch Inc | Year: 1977 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Range-finding toxicity data: List VIII | Author: Carpenter CP Weil CS Smyth Jr HF | Year: 1974 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Range-finding toxicity data: List VIII | Author: Carpenter CP Weil CS Smyth Jr HF | Year: 1974 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Untersuchungen zur akuten oralen Toxizit??t an|m??nnlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1984 | Guideline: 401 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untersuchungen zur akuten oralen Toxizit??t an|m??nnlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1984 | Guideline: 401 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 4-Hour Acute Inhalation Toxicity Study with Decamethylcyclopentasiloxane in Rats | Author: RCC Ltd | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 4-Hour Acute Inhalation Toxicity Study with Decamethylcyclopentasiloxane in Rats | Author: RCC Ltd | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Untersuchungen zur akuten|Inhalationstoxizität. | Author: Bayer AG | Year: 1984 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Untersuchungen zur akuten|Inhalationstoxizität. | Author: Bayer AG | Year: 1984 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Acute percutaneous toxicity in rabbits | Author: WIL Research Laboratories | Year: 1977 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Acute percutaneous toxicity in rabbits | Author: WIL Research Laboratories | Year: 1977 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Range-finding toxicity data: list VIII. | Author: Carpenter P et al. | Year: 1974 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Range-finding toxicity data: list VIII. | Author: Carpenter P et al. | Year: 1974 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Untersuchung zur akuten cutanen Toxizit??t an|m??nnlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1985 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Untersuchung zur akuten cutanen Toxizit??t an|m??nnlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1985 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of [14C]-methylcyclosiloxanes in rats | Author: Domoradzki JY Sushynski CM Sushynski JM McNett DA Landingham CV Plotzke KP | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism and disposition of [14C]-methylcyclosiloxanes in rats | Author: Domoradzki JY Sushynski CM Sushynski JM McNett DA Landingham CV Plotzke KP | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition and Pharmacokinetics of 14C-Decamethylcyclopentasiloxane (14C-D5) following Single Oral Gavage Administration to Fischer 344 Rats in a Liquid Diet Vehicle | Author: Dow Corning Corporation | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Disposition and Pharmacokinetics of 14C-Decamethylcyclopentasiloxane (14C-D5) following Single Oral Gavage Administration to Fischer 344 Rats in a Liquid Diet Vehicle | Author: Dow Corning Corporation | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution metabolism and excretion (ADME) study of decamethylcyclopentasiloxane (D5) in the rat following a 14-day nose-only vapour inhalation exposure to D5 followed by a single nose-only vapour inhalation exposure to 14C-D5 on day 15. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Absorption distribution metabolism and excretion (ADME) study of decamethylcyclopentasiloxane (D5) in the rat following a 14-day nose-only vapour inhalation exposure to D5 followed by a single nose-only vapour inhalation exposure to 14C-D5 on day 15. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: ADME Study of 14C D5 in the Rat following a Single Nose-only Vapor Inhalation Exposure to 14C-D5 at Two Dose Levels. | Author: Battelle | Year: 2001 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: ADME Study of 14C D5 in the Rat following a Single Nose-only Vapor Inhalation Exposure to 14C-D5 at Two Dose Levels. | Author: Battelle | Year: 2001 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: In vivo Percutaneous Absorption of 14C-Decamethylcyclopentasiloxane in the Rat | Author: Dow Corning Corporation | Year: 2003 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: In vivo Percutaneous Absorption of 14C-Decamethylcyclopentasiloxane in the Rat | Author: Dow Corning Corporation | Year: 2003 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 14C-Decmathylcyclopentasiloxane (D5) in Fisher 344 Rats when Delivered in Various Carriers Following the Administration of a Single Oral Dose. | Author: Dow Corning Corporation | Year: 2003 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Disposition of 14C-Decmathylcyclopentasiloxane (D5) in Fisher 344 Rats when Delivered in Various Carriers Following the Administration of a Single Oral Dose. | Author: Dow Corning Corporation | Year: 2003 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption of Decamethylcyclopentasiloxane (D5) using the flow-through diffusion cell system for in vitro dermal absorption in human skin. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Absorption of Decamethylcyclopentasiloxane (D5) using the flow-through diffusion cell system for in vitro dermal absorption in human skin. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: In vitro absorption of decamethylcyclopentasiloxane (D5) in human skin: A comparison octamethylcyclotetrasiloxane (D4) | Author: McMahon JM Plotzke KP Jovanovic ML McNett DA Gallvan RH|Meek RG | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: In vitro absorption of decamethylcyclopentasiloxane (D5) in human skin: A comparison octamethylcyclotetrasiloxane (D4) | Author: McMahon JM Plotzke KP Jovanovic ML McNett DA Gallvan RH|Meek RG | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: In Vitro Percutaneous Absorption of 14C-D5 in Rat Skin. | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: In Vitro Percutaneous Absorption of 14C-D5 in Rat Skin. | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dermal absorption of 14C-decamethylcyclopentasiloxane (D5) in rats | Author: Plotzke KP McMahon JM Hubbell BG Meeks RG Mast RW | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Dermal absorption of 14C-decamethylcyclopentasiloxane (D5) in rats | Author: Plotzke KP McMahon JM Hubbell BG Meeks RG Mast RW | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: In Vivo Percutaneous Absorption of 14C-D5 in Rat Skin. | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: In Vivo Percutaneous Absorption of 14C-D5 in Rat Skin. | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Identification of metabolites of decamethylcyclopentasiloxane in fat collected from Fischer 344 rats following a single oral dose | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Identification of metabolites of decamethylcyclopentasiloxane in fat collected from Fischer 344 rats following a single oral dose | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Human Dermal Absorption of Decamethylcyclopentasiloxane (D5) | Author: University of Rochester Medical Center | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Human Dermal Absorption of Decamethylcyclopentasiloxane (D5) | Author: University of Rochester Medical Center | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption Distribution and Excretion (ADE) study of 14C-decamethylcyclopentasiloxane (D5) in the female rat following a single nose-only vapour inhalation exposure to 14C-D5. | Author: Battelle | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Absorption Distribution and Excretion (ADE) study of 14C-decamethylcyclopentasiloxane (D5) in the female rat following a single nose-only vapour inhalation exposure to 14C-D5. | Author: Battelle | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Metabolites of decamethylcyclopentasiloxane (D5) in Rat Urine. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Metabolites of decamethylcyclopentasiloxane (D5) in Rat Urine. | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in Fischer 344 rat urine | Author: Varaprath S. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in Fischer 344 rat urine | Author: Varaprath S. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A Study of Excretion of MESiO3/2 Moieties After Oral Administration of D5 | Author: Dow Corning Corporation | Year: 1988 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: A Study of Excretion of MESiO3/2 Moieties After Oral Administration of D5 | Author: Dow Corning Corporation | Year: 1988 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Monte Carlo analysis of tissue concentrations following occupational exposure to octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane using a physiologically based pharmacokinetic model. | Author: Clewell Andersen Tan and Yang | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Monte Carlo analysis of tissue concentrations following occupational exposure to octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane using a physiologically based pharmacokinetic model. | Author: Clewell Andersen Tan and Yang | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronische toxikologische Untersuchungen an Ratten (Magensondenapplikation über 13 Wochen) | Author: Bayer AG | Year: 1991 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Subchronische toxikologische Untersuchungen an Ratten (Magensondenapplikation über 13 Wochen) | Author: Bayer AG | Year: 1991 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A 28-day subchronic oral gavage feasibility study of various low molecular weight silicone oligomers in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: A 28-day subchronic oral gavage feasibility study of various low molecular weight silicone oligomers in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 14-day subchronic oral gavage study with decamethylcyclopentasiloxane in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 14-day subchronic oral gavage study with decamethylcyclopentasiloxane in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5): A 24-month combined chronic toxicity and oncogenicity whole body vapour inhalation study in Fischer-344 rats. | Author: RCC Ltd | Year: 2005 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5): A 24-month combined chronic toxicity and oncogenicity whole body vapour inhalation study in Fischer-344 rats. | Author: RCC Ltd | Year: 2005 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Three Month Repeated Dose Inhalation Toxicity Study with decamethylcyclopentasiloxane in Rats. | Author: RCC Ltd | Year: 1995 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Three Month Repeated Dose Inhalation Toxicity Study with decamethylcyclopentasiloxane in Rats. | Author: RCC Ltd | Year: 1995 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation toxicology of Decamethylcyclopentasiloxane (D5) following a 3-month nose-only exposure in Fischer 344 rats. | Author: Burns-Naas L A et al. | Year: 1998 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Inhalation toxicology of Decamethylcyclopentasiloxane (D5) following a 3-month nose-only exposure in Fischer 344 rats. | Author: Burns-Naas L A et al. | Year: 1998 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 90-day inhalation study of decamethylcyclopentasiloxane (D5) in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 90-day inhalation study of decamethylcyclopentasiloxane (D5) in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: One-Month Repeated Dose Inhalation Toxicity with decamethylcyclopentasiloxane in Rats. | Author: RCC Ltd | Year: 1995 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: One-Month Repeated Dose Inhalation Toxicity with decamethylcyclopentasiloxane in Rats. | Author: RCC Ltd | Year: 1995 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Effects of 4-week vapor inhalation of decamethylcyclopentasiloxane (D5) on Fischer 344 rats | Author: Kelly DW Neun DJ Thevenaz Ph Meeks RG and Mast RW | Year: 1995 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Effects of 4-week vapor inhalation of decamethylcyclopentasiloxane (D5) on Fischer 344 rats | Author: Kelly DW Neun DJ Thevenaz Ph Meeks RG and Mast RW | Year: 1995 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 28-Day Inhalation Toxicity and Splenic Antibody Formation Study of decamethylcyclopentasiloxane (D5) in Rats. | Author: WIL Research Laboratories Inc | Year: 1996 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 28-Day Inhalation Toxicity and Splenic Antibody Formation Study of decamethylcyclopentasiloxane (D5) in Rats. | Author: WIL Research Laboratories Inc | Year: 1996 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicology and Humoral Immunity Assessment of D5 following a 1-Month Whole Body Inhalation Exposure in Fischer 344 Rats. | Author: Burns-Naas L A et al. | Year: 1998 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Toxicology and Humoral Immunity Assessment of D5 following a 1-Month Whole Body Inhalation Exposure in Fischer 344 Rats. | Author: Burns-Naas L A et al. | Year: 1998 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicological and humoral immunity assessment in rats exposed for 28 days to decamethylcyclopentasiloxane (D5) vapor | Author: Burns LA Mast RW Naas DJ McCay JA and Klykken PC | Year: 1996 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Toxicological and humoral immunity assessment in rats exposed for 28 days to decamethylcyclopentasiloxane (D5) vapor | Author: Burns LA Mast RW Naas DJ McCay JA and Klykken PC | Year: 1996 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Non-regulated study: Effects of decamethylcyclopentasiloxane (D5) on cell proliferation in the liver of female Fischer 344 rats: a 28-day inhalation study. | Author: Dow Corning Corporation | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Non-regulated study: Effects of decamethylcyclopentasiloxane (D5) on cell proliferation in the liver of female Fischer 344 rats: a 28-day inhalation study. | Author: Dow Corning Corporation | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Sub-acute inhalation toxicity study of silicone oil KF 995 in rats. | Author: TNO | Year: 1984 | Guideline: 412 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Sub-acute inhalation toxicity study of silicone oil KF 995 in rats. | Author: TNO | Year: 1984 | Guideline: 412 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 28-day dermal study of decamethylcyclopentasiloxane (D5) in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 410 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 28-day dermal study of decamethylcyclopentasiloxane (D5) in rats. | Author: Dow Corning Corporation | Year: 1990 | Guideline: 410 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Twenty-one day repeated dermal in the rabbit of material SF-1202 | Author: Huntingdon Research Center | Year: 1979 | Guideline: 410 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: dermal | Right to refer to study -- Title: Twenty-one day repeated dermal in the rabbit of material SF-1202 | Author: Huntingdon Research Center | Year: 1979 | Guideline: 410 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Subakute toxikologische Untersuchungen|an Kanninchen. | Author: Bayer AG | Year: 1988 | Guideline: 410 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: dermal | Right to refer to study -- Title: Subakute toxikologische Untersuchungen|an Kanninchen. | Author: Bayer AG | Year: 1988 | Guideline: 410 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: 28-Day percutaneous Toxicity study | Author: Muller D | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: dermal | Right to refer to study -- Title: 28-Day percutaneous Toxicity study | Author: Muller D | Year: 1978 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) (CAS RN 541-02-6): Whole-Body Inhalation Developmental Toxicity Study in Crl:CD(SD) Rats | Author: The Dow Chemical Company (Toxicology and Environmental Research and Consulting) | Year: 2020 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) (CAS RN 541-02-6): Whole-Body Inhalation Developmental Toxicity Study in Crl:CD(SD) Rats | Author: The Dow Chemical Company (Toxicology and Environmental Research and Consulting) | Year: 2020 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Whole-Body Inhalation Prenatal Developmental Toxicity Study of Decamethylcyclopentasiloxane (D5 [CAS RN 541-02-6]) in New Zealand White Rabbits | Author: Charles River Laboratories Ashland | Year: 2020 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Whole-Body Inhalation Prenatal Developmental Toxicity Study of Decamethylcyclopentasiloxane (D5 [CAS RN 541-02-6]) in New Zealand White Rabbits | Author: Charles River Laboratories Ashland | Year: 2020 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Whole-Body Inhalation Dose Range-Finding Toxicity Study of Decamethylcyclopentasiloxane (D5 [CAS RN 541-02-6]) in Nonpregnant New Zealand White Rabbits | Author: Charles River Laboratories Ashland LLC 1407 George Road Ashland OH 44805 United States | Year: 2020 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Whole-Body Inhalation Dose Range-Finding Toxicity Study of Decamethylcyclopentasiloxane (D5 [CAS RN 541-02-6]) in Nonpregnant New Zealand White Rabbits | Author: Charles River Laboratories Ashland LLC 1407 George Road Ashland OH 44805 United States | Year: 2020 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A Two-Generation Inhalation Reproductive Toxicity and Developmental Neurotoxicity Study of decamethylcyclopentasiloxane (D5) in Rats. | Author: WIL Research Laboratories Inc | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A Two-Generation Inhalation Reproductive Toxicity and Developmental Neurotoxicity Study of decamethylcyclopentasiloxane (D5) in Rats. | Author: WIL Research Laboratories Inc | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Evaluation of|decamethylcyclopentasiloxane (D5) in a 2-generation|inhalation reproductive study in rats | Author: Stump DG. et al. | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Evaluation of|decamethylcyclopentasiloxane (D5) in a 2-generation|inhalation reproductive study in rats | Author: Stump DG. et al. | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: An Inhalation Range Finding Reproductive Toxicity Study of decamethylcyclopentasiloxane (D5) in the Rat. | Author: WIL Research Laboratories Inc | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: An Inhalation Range Finding Reproductive Toxicity Study of decamethylcyclopentasiloxane (D5) in the Rat. | Author: WIL Research Laboratories Inc | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5): A 24-month combined chronic toxicity and oncogenicity whole body vapour inhalation study in Fischer-344 rats. | Author: RCC Ltd | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5): A 24-month combined chronic toxicity and oncogenicity whole body vapour inhalation study in Fischer-344 rats. | Author: RCC Ltd | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: In vitro effects of siloxanes on human immune cells. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: In vitro effects of siloxanes on human immune cells. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Non-regulated study: In vivo evaluation of the impact of exposure/endpoint evaluation timing on the potential for octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane to affect circulating prolactin levels in the reserpine-treated female F344 rat | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Non-regulated study: In vivo evaluation of the impact of exposure/endpoint evaluation timing on the potential for octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane to affect circulating prolactin levels in the reserpine-treated female F344 rat | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Effects of decamethylcyclopentasiloxane (D5) on Hepatic Cytochrome P450 UDP-glucuronosyltransferase and epoxide hydrolase in the Female Fischer 344 Rat. | Author: WIL Research Laboratories Inc | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Effects of decamethylcyclopentasiloxane (D5) on Hepatic Cytochrome P450 UDP-glucuronosyltransferase and epoxide hydrolase in the Female Fischer 344 Rat. | Author: WIL Research Laboratories Inc | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Induction of Hepatic P450 1A1 and 2B1 following repeated inhalation exposure to decamethylcyclopentasiloxane D5. | Author: McKim J M et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Induction of Hepatic P450 1A1 and 2B1 following repeated inhalation exposure to decamethylcyclopentasiloxane D5. | Author: McKim J M et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Induction of Hepatic Xenobiotic Metabolizing Enzymes in Female Fischer 344 Rats following Repeated Inhalation Exposure to D5. | Author: McKim J M et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Induction of Hepatic Xenobiotic Metabolizing Enzymes in Female Fischer 344 Rats following Repeated Inhalation Exposure to D5. | Author: McKim J M et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Non-Regulated Study: Effect of octamethylcyclotetrasiloxane (D4 CAS No. 556-67-2) and decamethylcyclopentasiloxane (D5 CAS No. 541-02-6) on circulating prolactin levels in the aged female Fischer 344 rat | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Non-Regulated Study: Effect of octamethylcyclotetrasiloxane (D4 CAS No. 556-67-2) and decamethylcyclopentasiloxane (D5 CAS No. 541-02-6) on circulating prolactin levels in the aged female Fischer 344 rat | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Evaluation of the Liver Microsomal Enzyme Induction Potential of D5. | Author: Dow Corning Corporation | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Evaluation of the Liver Microsomal Enzyme Induction Potential of D5. | Author: Dow Corning Corporation | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes. | Author: Zhang J et al. | Year: 2000 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes. | Author: Zhang J et al. | Year: 2000 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes. | Author: Zhang J et al. | Year: 1999 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes. | Author: Zhang J et al. | Year: 1999 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Evaluation of D5 as a Potential Inhibitor of Human and Rat Cytochrome P450 Enzymes. | Author: Dow Corning Corporation | Dow Corning Corporation | Year: 2000 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Evaluation of D5 as a Potential Inhibitor of Human and Rat Cytochrome P450 Enzymes. | Author: Dow Corning Corporation | Dow Corning Corporation | Year: 2000 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Potential for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane to Interact With and Activate the Dopamine D2 Receptor in Rat Striatal Membranes | Author: University of Florida | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Potential for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane to Interact With and Activate the Dopamine D2 Receptor in Rat Striatal Membranes | Author: University of Florida | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Decamethylcyclopentasiloxane - 14 - Day Prolonged Acute Toxicity to Rainbow Trout (Oncorhynchus mykiss) Under Flow - Through Conditions. | Author: Springborn Laboratories Inc. | Year: 2000 | Guideline: 204 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Decamethylcyclopentasiloxane - 14 - Day Prolonged Acute Toxicity to Rainbow Trout (Oncorhynchus mykiss) Under Flow - Through Conditions. | Author: Springborn Laboratories Inc. | Year: 2000 | Guideline: 204 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: 14C-Decamethylcyclopentasiloxane (14C-D5): Bioconcentration in the Fathead Minnow (Pimephales promelas) Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: 14C-Decamethylcyclopentasiloxane (14C-D5): Bioconcentration in the Fathead Minnow (Pimephales promelas) Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Siliconflussigkeit NM 4005 Determination of the Acute Toxicity to Fish | Author: Huls Infracor | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Siliconflussigkeit NM 4005 Determination of the Acute Toxicity to Fish | Author: Huls Infracor | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: unpublished report of Bayer AG | Author: Grau | Year: 1991 | Guideline: 204 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: unpublished report of Bayer AG | Author: Grau | Year: 1991 | Guideline: 204 | Klimisch score: 4 (not assignable) | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Decamethylcyclopentasiloxane - Acute Toxicity to Daphnids (Daphnia magna) Under Flow-Through Conditions. | Author: Springborn Smithers | Year: 2002 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Decamethylcyclopentasiloxane - Acute Toxicity to Daphnids (Daphnia magna) Under Flow-Through Conditions. | Author: Springborn Smithers | Year: 2002 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Siliconflussigkeit NM 4005 Determination of the Acute Toxicity to Daphnia. Report . | Author: Huls | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Siliconflussigkeit NM 4005 Determination of the Acute Toxicity to Daphnia. Report . | Author: Huls | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: No information | Author: Bayer AG | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: No information | Author: Bayer AG | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout | Author: Borg?? K Fjeld E Kierkiegaard A McLachlan M S | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout | Author: Borg?? K Fjeld E Kierkiegaard A McLachlan M S | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) - Toxicity to the Freshwater Green Alga Pseudokirchneriella subcapitata | Author: Springborn Laboratories Inc. | Year: 2001 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Dietary bioaccumulation study of D4 and D5 in carp | Author: CERI | Year: 2011 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Dietary bioaccumulation study of D4 and D5 in carp | Author: CERI | Year: 2011 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) - Toxicity to the Freshwater Green Alga Pseudokirchneriella subcapitata | Author: Springborn Laboratories Inc. | Year: 2001 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioconcentration study of decamethylcyclopentasiloxane (test item number K-1842) in carp (report in Japanese) | Author: CERI | Year: 2010 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioconcentration study of decamethylcyclopentasiloxane (test item number K-1842) in carp (report in Japanese) | Author: CERI | Year: 2010 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Siliconeflussigkeit NM 4004 Growth Inhibition of the Green Algae Scenedesmus subspicatus 86.81.SAG | Author: Huls Infracor | Year: 1999 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: 96-Hour metabolism studies in rainbow trout (Oncorhynchus mykiss) orally gavaged with 14C-octamethylcyclotetrasiloxane ([14C]D4) or 14C-decamethylcyclopentasiloxane ([14C]D5) | Author: Domoradzki JY Sushynski JM Thackery LM Springer TA Ross TL Woodburn KB Durham JA McNett DA | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: 96-Hour metabolism studies in rainbow trout (Oncorhynchus mykiss) orally gavaged with 14C-octamethylcyclotetrasiloxane ([14C]D4) or 14C-decamethylcyclopentasiloxane ([14C]D5) | Author: Domoradzki JY Sushynski JM Thackery LM Springer TA Ross TL Woodburn KB Durham JA McNett DA | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Siliconeflussigkeit NM 4004 Growth Inhibition of the Green Algae Scenedesmus subspicatus 86.81.SAG | Author: Huls Infracor | Year: 1999 | Klimisch score: 4 (not assignable) | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Whole Body Autoradiography in Rainbow Trout (Oncorhynchus mykiss) Exposed to 14C- Octamethylcyclotetrasiloxane ([14C]D4) or 14C-Decamethylcyclopentasiloxane ([14C]D5) Following Diertary Bioaccumulation under Flow-Through Condisitons | Author: Domoradzki J. Jezowski R. Regan J. Plotzke Kathleen KP. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Whole Body Autoradiography in Rainbow Trout (Oncorhynchus mykiss) Exposed to 14C- Octamethylcyclotetrasiloxane ([14C]D4) or 14C-Decamethylcyclopentasiloxane ([14C]D5) Following Diertary Bioaccumulation under Flow-Through Condisitons | Author: Domoradzki J. Jezowski R. Regan J. Plotzke Kathleen KP. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Siliconflüssigkeit (Silicone liquid) NM 4005. Determination of Respiration Inhibition of Activated Sludge (88/302/EWG). | Author: Diefenbach R | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Environmental Contaminants in an Urban Fjord 2015 | Author: Norwegian Institute for Water Research (NIVA) | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Siliconflüssigkeit (Silicone liquid) NM 4005. Determination of Respiration Inhibition of Activated Sludge (88/302/EWG). | Author: Diefenbach R | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Environmental Contaminants in an Urban Fjord 2015 | Author: Norwegian Institute for Water Research (NIVA) | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) - Early Life-Stage Toxicity Test with Rainbow Trout (Oncorhynchus mykiss) Following OECD Guideline #210 and OPPTS Draft Guideline 850.1400. | Author: Springborn Smithers | Year: 2009 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Trophic Transfer of Methyl Siloxanes in the Marine Food Web from Coastal Area of Northern China | Author: Jia H. Zhang Z. Wang C. Hong W-J. Sun Y. and Li Y-F | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) - Early Life-Stage Toxicity Test with Rainbow Trout (Oncorhynchus mykiss) Following OECD Guideline #210 and OPPTS Draft Guideline 850.1400. | Author: Springborn Smithers | Year: 2009 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Trophic Transfer of Methyl Siloxanes in the Marine Food Web from Coastal Area of Northern China | Author: Jia H. Zhang Z. Wang C. Hong W-J. Sun Y. and Li Y-F | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: D5: A Prolonged Sediment Toxicity Test With Chironomus riparius Using Spiked Sediment. | Author: Wildlife International | Year: 2008 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: 14C-Decamethylcyclopentasiloxane (14C-D5): Bioconcentration in the fathead minnow (Pimephales promelas) under flow-through test conditions. | Author: Dow Corning Corporation | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: D5: A Prolonged Sediment Toxicity Test With Chironomus riparius Using Spiked Sediment. | Author: Wildlife International | Year: 2008 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) - The Full Life-Cycle Toxicity To Midge (Chironomus riparius) Under Static Conditions. | Author: Springborn Smithers | Year: 2003 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: 14C-Decamethylcyclopentasiloxane (14C-D5): Bioconcentration in the fathead minnow (Pimephales promelas) under flow-through test conditions. | Author: Dow Corning Corporation | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) - The Full Life-Cycle Toxicity To Midge (Chironomus riparius) Under Static Conditions. | Author: Springborn Smithers | Year: 2003 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: D5: A prolonged sediment toxicity test with Lumbriculus variegatus using spiked sediment. | Author: Wildlife International | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Bioconcentration of Decamethylcyclopentasiloxane in Rainbow Trout. | Author: Dow Corning | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: D5: A prolonged sediment toxicity test with Lumbriculus variegatus using spiked sediment. | Author: Wildlife International | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: 28-Day Toxicity Test Exposing Freshwater Amphipods (Hyalella azteca) to D5 Applied to Sediment Under Static-Renewal Conditions Following OPPTS Draft Guideline 850.1735 | Author: Springborn Smithers | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Bioconcentration of Decamethylcyclopentasiloxane in Rainbow Trout. | Author: Dow Corning | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: 28-Day Toxicity Test Exposing Freshwater Amphipods (Hyalella azteca) to D5 Applied to Sediment Under Static-Renewal Conditions Following OPPTS Draft Guideline 850.1735 | Author: Springborn Smithers | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) Spiked Sediment: Bioaccumulation and Toxicity in the Benthic Invertebrate Hyalella azteca | Author: Priority Substances Effects Aquatic Ecosystems Protection Research Division Water Science and Technology Directorate Burlington ON | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5): Prolonged Toxicity to the Rainbow Trout (Oncorhynchus mykiss) under Flow-Through Test Conditions. | Author: Dow Corning | Year: 2009 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) Spiked Sediment: Bioaccumulation and Toxicity in the Benthic Invertebrate Hyalella azteca | Author: Priority Substances Effects Aquatic Ecosystems Protection Research Division Water Science and Technology Directorate Burlington ON | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5): Prolonged Toxicity to the Rainbow Trout (Oncorhynchus mykiss) under Flow-Through Test Conditions. | Author: Dow Corning | Year: 2009 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) - Determination of the Effects on Soil Microflora Activity | Author: Smithers Viscient | Year: 2019 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Fathead minnow (Pimephales promelas) egg-to-juvenile exposure to decamethylcyclopentasiloxane (D5) | Author: Ecological Assessment Division Environment Canada | Year: 2010 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) - Determination of the Effects on Soil Microflora Activity | Author: Smithers Viscient | Year: 2019 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Fathead minnow (Pimephales promelas) egg-to-juvenile exposure to decamethylcyclopentasiloxane (D5) | Author: Ecological Assessment Division Environment Canada | Year: 2010 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Ecotoxicity of siloxane D5 in soil | Author: Velicogna et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) - Full Life-Cycle Toxicity Test with Water Fleas (Daphnia magna) Under Static-Renewal Conditions. | Author: Springborn Smithers Laboratories Inc. | Year: 2003 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Ecotoxicity of siloxane D5 in soil | Author: Velicogna et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: D5 - Chronic Toxicity and Reproduction Test Exposing the Earthworm Eisenia fetida in Natural Sandy Loam Based on OECD Guideline 222 | Author: Smithers Viscient | Year: 2015 | Guideline: 222 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) - Full Life-Cycle Toxicity Test with Water Fleas (Daphnia magna) Under Static-Renewal Conditions. | Author: Springborn Smithers Laboratories Inc. | Year: 2003 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: D5 - Chronic Toxicity and Reproduction Test Exposing the Earthworm Eisenia fetida in Natural Sandy Loam Based on OECD Guideline 222 | Author: Smithers Viscient | Year: 2015 | Guideline: 222 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Ecotoxicity of siloxane D5 in soil | Author: Velicogna et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to terrestrial plants | Right to refer to study -- Title: Ecotoxicity of siloxane D5 in soil | Author: Velicogna et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: 14C-Decamethylcyclopentasiloxane (14C-D5): Bioconcentration in the Fathead Minnow (Pimephales promelas) Under Flow-Through Test Conditions. | Author: Drottar K.R. | Year: 2005 | Guideline: 305 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to birds | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5): Reproductive Toxicity Test with Japanese Quail (Coturnix coturnix japonica) | Author: Smithers Viscient | Year: 2013 | Guideline: 206 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to birds | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5): Reproductive Toxicity Test with Japanese Quail (Coturnix coturnix japonica) | Author: Smithers Viscient | Year: 2013 | Guideline: 206 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: 14C-Decamethylcyclopentasiloxane (14C-D5): Bioconcentration in the Fathead Minnow (Pimephales promelas) Under Flow-Through Test Conditions. | Author: Drottar K.R. | Year: 2005 | Guideline: 305 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Robust Study Summary -- Title: Ecotoxicity of siloxane D5 in soil | Author: Velicogna et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Right to refer to study -- Title: Ecotoxicity of siloxane D5 in soil | Author: Velicogna et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioconcentration of Decamethylcyclopentasiloxane in Rainbow Trout. | Author: Dow Corning Corporation | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioconcentration of Decamethylcyclopentasiloxane in Rainbow Trout. | Author: Dow Corning Corporation | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Decamethylcyclopentasiloxane | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: 14C-Octamethylcyclopentasiloxane (14C-D5): Dietary Bioaccumulation in the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Drottar K R | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: 14C-Octamethylcyclopentasiloxane (14C-D5): Dietary Bioaccumulation in the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Drottar K R | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Decamethylcyclopentasiloxane | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: NON-REGULATED STUDY. Determination of a biomagnification factor for decamethylcyclopentasiloxane (D5) from a fish feeding study in rainbow trout (Oncorhynchus mykiss) | Author: Domoradzki JY and Woodburn KB | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: NON-REGULATED STUDY. Determination of a biomagnification factor for decamethylcyclopentasiloxane (D5) from a fish feeding study in rainbow trout (Oncorhynchus mykiss) | Author: Domoradzki JY and Woodburn KB | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Cyclopentasiloxane decamethyl- (D5) and Cyclotrisiloxane hexamethyl- (D3) - Determination of the Biodegradability of a Test Substance | Author: Gledhill W E . | Year: 2004 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: NON-REGULATED STUDY: Prediction of Dietary Biomagnification Factors for Cyclic Siloxanes from Bioconcentration Data | Author: Domoradzki J Y | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: NON-REGULATED STUDY: Prediction of Dietary Biomagnification Factors for Cyclic Siloxanes from Bioconcentration Data | Author: Domoradzki J Y | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Cyclopentasiloxane decamethyl- (D5) and Cyclotrisiloxane hexamethyl- (D3) - Determination of the Biodegradability of a Test Substance | Author: Gledhill W E . | Year: 2004 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: NON-REGULATED STUDY: A Physiologically Based Pharmacokinetic Model in Rainbow Trout (Oncorynchus mykiss) for Decamethylcyclopentasiloxane (D5) by Dietary and Water Routes of Exposure | Author: Domoradzki J Y | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Soil-Water Distribution of Decamethylcyclopentasiloxane (D5) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2007 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: NON-REGULATED STUDY: A Physiologically Based Pharmacokinetic Model in Rainbow Trout (Oncorynchus mykiss) for Decamethylcyclopentasiloxane (D5) by Dietary and Water Routes of Exposure | Author: Domoradzki J Y | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Soil-Water Distribution of Decamethylcyclopentasiloxane (D5) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2007 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: D5: A bioaccumulation test with Lumbriculus variegatus using spiked sediment. | Author: Krueger H Thomas S and Kendall T | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: D5: A bioaccumulation test with Lumbriculus variegatus using spiked sediment. | Author: Krueger H Thomas S and Kendall T | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Aerobic and anaerobic transformation of decamethylcyclopentasiloxane (14C-D5) in aquatic sediment systems | Author: Dow Corning Corporation | Year: 2010 | Guideline: 308 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) - The full life-cycle toxicity test with midge (chironomus riparius) under static conditions | Author: Dow Corning Corporation | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Aerobic and anaerobic transformation of decamethylcyclopentasiloxane (14C-D5) in aquatic sediment systems | Author: Dow Corning Corporation | Year: 2010 | Guideline: 308 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Other distribution data | Robust Study Summary -- Title: The fate of cyclic methylsiloxanes in soils: 2. Rates of degradation and volatilization. | Author: Xu S and Chandra G | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) - The full life-cycle toxicity test with midge (chironomus riparius) under static conditions | Author: Dow Corning Corporation | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Other distribution data | Right to refer to study -- Title: The fate of cyclic methylsiloxanes in soils: 2. Rates of degradation and volatilization. | Author: Xu S and Chandra G | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Other distribution data | Robust Study Summary -- Title: Fate of Cyclic Methylsiloxanes in Soils: 1. The Degradation Pathway. | Author: Xu S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Decamethylcyclopentasiloxane (D5) Spiked Sediment: Bioaccumulation and Toxicity in the Benthic Invertebrate Hyalella azteca | Author: Environment Canada | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Other distribution data | Right to refer to study -- Title: Fate of Cyclic Methylsiloxanes in Soils: 1. The Degradation Pathway. | Author: Xu S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Other distribution data | Robust Study Summary -- Title: Estimation of Degradation Rates of cVMS in soils | Author: Xu S | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Decamethylcyclopentasiloxane (D5) Spiked Sediment: Bioaccumulation and Toxicity in the Benthic Invertebrate Hyalella azteca | Author: Environment Canada | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Other distribution data | Right to refer to study -- Title: Estimation of Degradation Rates of cVMS in soils | Author: Xu S | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Kinetics of the Gas-Phase Reactions of a Series of Organosilicon Compounds with OH and NO3 Radicals and O3 at 297 ?? 2 K | Author: Atkinson R | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Fathead minnow (Pimephales promelas) egg-to-juvenile exposure to decamethylcyclopentasiloxane (D5) | Author: Ecological Assessment Division Environment Canada | Year: 2010 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Kinetics of the Gas-Phase Reactions of a Series of Organosilicon Compounds with OH and NO3 Radicals and O3 at 297 ?? 2 K | Author: Atkinson R | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Quantitative structure-reactivity relationships of hydroxyl radical rate constants for linear and cyclic volatile methylsiloxanes | Author: Kim J. Xu S. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Fathead minnow (Pimephales promelas) egg-to-juvenile exposure to decamethylcyclopentasiloxane (D5) | Author: Ecological Assessment Division Environment Canada | Year: 2010 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Quantitative structure-reactivity relationships of hydroxyl radical rate constants for linear and cyclic volatile methylsiloxanes | Author: Kim J. Xu S. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: USEPA SRC | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioaccumulation and Trophic Transfer of Cyclic Volatile Methylsiloxane (cVMS) Materials in the Aquatic Marine Food Webs of the Inner and Outer Oslofjord Norway | Author: David E. Powell et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: No information | Author: USEPA SRC | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Rate Constants and Activation Energies for Gas-Phase Reactions of Three Cyclic Volatile Methyl Siloxanes with the Hydroxyl Radical | Author: Safron A. Strandell M. Kierkegaard A. Macleod M | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioaccumulation and Trophic Transfer of Cyclic Volatile Methylsiloxane (cVMS) Materials in the Aquatic Marine Food Webs of the Inner and Outer Oslofjord Norway | Author: David E. Powell et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Rate Constants and Activation Energies for Gas-Phase Reactions of Three Cyclic Volatile Methyl Siloxanes with the Hydroxyl Radical | Author: Safron A. Strandell M. Kierkegaard A. Macleod M | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Kinetics and Mechanism of the Oxidation of Cyclic Methylsiloxanes by Hydroxyl Radical in the Gas Phase: An Experimental and Theoretical Study | Author: Xiao R. Zammit I. Wei Z. Hu W-P. MacLeod M Spinney R. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioaccumulation and Trophic Transfer of Cyclic Volatile Methylsiloxane (cVMS) Materials in the Aquatic Marine Food Webs of the Inner and Outer Oslofjord Norway | Author: Powell D. E. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Kinetics and Mechanism of the Oxidation of Cyclic Methylsiloxanes by Hydroxyl Radical in the Gas Phase: An Experimental and Theoretical Study | Author: Xiao R. Zammit I. Wei Z. Hu W-P. MacLeod M Spinney R. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioaccumulation and Trophic Transfer of Cyclic Volatile Methylsiloxane (cVMS) Materials in the Aquatic Marine Food Webs of the Inner and Outer Oslofjord Norway | Author: Powell D. E. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Trophic Dilution of Cyclic Volatile Methylsiloxane (cVMS) Materials in a Temperate Freshwater Lake. | Author: Powell D. E. et al. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Xu S Kropscott B | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Trophic Dilution of Cyclic Volatile Methylsiloxane (cVMS) Materials in a Temperate Freshwater Lake. | Author: Powell D. E. et al. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Food web accumulation of cyclic siloxanes in Lake Mj??sa Norway | Author: Borg?? K Fjeld E Kierkiegaard A McLachlan M S | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Xu S Kropscott B | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Food web accumulation of cyclic siloxanes in Lake Mj??sa Norway | Author: Borg?? K Fjeld E Kierkiegaard A McLachlan M S | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioaccumulation behaviors and trophic transfer of cyclic volatile methylsiloxanes (cVMS) and polychlorinated biphenyl (PCB) congeners in the pelagic marine food web of Tokyo Bay - Interim Report for Tokyo Bay Preliminary Study | Author: Powell D. E. et al. | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethylcyclopentasiloxane (D5) by the Slow-Stirring Method Using Gas Chromogratography and Mass Spectrometry. | Author: Kozerski G E Shawl H R | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioaccumulation behaviors and trophic transfer of cyclic volatile methylsiloxanes (cVMS) and polychlorinated biphenyl (PCB) congeners in the pelagic marine food web of Tokyo Bay - Interim Report for Tokyo Bay Preliminary Study | Author: Powell D. E. et al. | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie Canada | Author: McGoldrick Daryl J. Chan Cecilia Drouillard Ken G. Keir Michael J. Clark Mandi G. Backus Sean M. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethylcyclopentasiloxane (D5) by the Slow-Stirring Method Using Gas Chromogratography and Mass Spectrometry. | Author: Kozerski G E Shawl H R | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie Canada | Author: McGoldrick Daryl J. Chan Cecilia Drouillard Ken G. Keir Michael J. Clark Mandi G. Backus Sean M. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |