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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Sax NI | Year: 1979 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physical properties of propylene glycol. | Author: Jones WS; Tamplin WS | Year: 1952 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Puck TT; Wise H | Year: 1945 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Physical properties of propylene glycol. | Author: Jones WS; Tamplin WS | Year: 1952 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Puck TT; Wise H | Year: 1945 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Weast RC; Astle MJ | Year: 1983 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Weast RC; Astle MJ | Year: 1983 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physical properties of propylene glycol. | Author: Jones WS; Tamplin WS | Year: 1952 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Puck TT; Wise H | Year: 1945 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical properties of propylene glycol | Author: Jones WS; Tamplin WS | Year: 1952 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Puck TT; Wise H | Year: 1945 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Monopropylene glycol:determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Monopropylene glycol:determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 107/117/122/123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 107/117/122/123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: A study of the n-octanol/water partitioning of propylene glycol | Author: Verschueren K | Year: 1983 | Guideline: 107/117/122/123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Weast RC; Astle MJ | Year: 1983 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 115 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 115 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Guideline: A.15-16 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.15-16 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.15-16 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Densities Dynamic Viscosities Speeds of Sound and Relative Permittivities for Water + Alkanediols (Propane-l2- and -13-diol and Butane-l2- -13- -14- and -23-Diol) at Different Temperatures | Author: George J; Sastry NV | Year: 2003 | Guideline: 114 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Densities Excess Molar Volumes Viscosities Speeds of Sound Excess Isentropic Compressibilities and Relative Permittivities for Alkyl (Methyl Ethyl Butyl and Isoamyl) Acetates + Glycols at Different Temperatures | Author: Sastry NV; Patel MC | Year: 2003 | Guideline: 114 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: AOPWIN™ Version 1.92 http://www.epa.gov/oppt/exposure/pubs/episuite.htm | Author: ARCO Chemical Company | Year: 1990 | Guideline: 301 A-F | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: AOPWIN™ Version 1.92 http://www.epa.gov/oppt/exposure/pubs/episuite.htm | Author: ARCO Chemical Company | Year: 1990 | Guideline: 301 A-F | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradability relationships among propylene glycol substances in the organization for economic cooperation and development ready- and seawater biodegradability tests | Author: West RJ et al. | Year: 2007 | Guideline: 301 A-F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of ready biodegradability of propylene glycol using the OECD method 301F: manometric respirometry test. | Author: The Dow Chemical Company | Year: 1999 | Guideline: 301 A-F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of ready biodegradability of propylene glycol using the OECD method 301F: manometric respirometry test. | Author: The Dow Chemical Company | Year: 1999 | Guideline: 301 A-F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Anaerobic biodegradation of propylene glycol in soil | Author: The Dow Chemical Company | Year: 1986 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Anaerobic biodegradation of propylene glycol in soil | Author: The Dow Chemical Company | Year: 1986 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Handbook of Chemical Property Estimation Methods McGraw -Hill New York. | Author: Lyman WJ | Year: 1982 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Technical Guidance Document on Risk Assessment | Author: ECB | Year: 2003 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: No information | Author: ARCO Chemical Company | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: No information | Author: ARCO Chemical Company | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Evaluation of the acute toxicity of industrial grade propylene glycol to representative freshwater organisms | Author: The Dow Chemical Company | Year: 1993 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Evaluation of the acute toxicity of industrial grade propylene glycol to representative freshwater organisms | Author: The Dow Chemical Company | Year: 1993 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Assessment of the toxicity of propylene glycol to the marine fish Scopthalmus maximus | Author: ARCO Chemical Company | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Assessment of the toxicity of propylene glycol to the marine fish Scopthalmus maximus | Author: ARCO Chemical Company | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Chemical substances testing. Final study report: ecotoxicological evaluation of propylene glycol (12-propanediol) | Author: The Dow Chemical Company | Year: 1981 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Chemical substances testing. Final study report: ecotoxicological evaluation of propylene glycol (12-propanediol) | Author: The Dow Chemical Company | Year: 1981 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Assessment of the toxicity of propylene glycol to the marine copepod Acartia tonsa | Author: The Dow Chemical Company | Year: 1981 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Assessment of the toxicity of propylene glycol to the marine copepod Acartia tonsa | Author: The Dow Chemical Company | Year: 1981 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Static acute toxicity of propylene glycol to the mysid Mysidopsis bahia. | Author: ARCO Chemical Company | Year: 1990 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Static acute toxicity of propylene glycol to the mysid Mysidopsis bahia. | Author: ARCO Chemical Company | Year: 1990 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Static Acute Toxicity of Propylene Glycol to the Daphnid Daphnia magna | Author: ARCO Chemical Company | Year: 1990 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Static Acute Toxicity of Propylene Glycol to the Daphnid Daphnia magna | Author: ARCO Chemical Company | Year: 1990 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparative toxicity of formulated glycol deicers and pure ethylene and propylene glycol to Ceriodaphnia dubia and Pimephales promelas | Author: Pillard DA | Year: 1995 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparative toxicity of formulated glycol deicers and pure ethylene and propylene glycol to Ceriodaphnia dubia and Pimephales promelas. | Author: Pillard DA | Year: 1995 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Static Acute Toxicity of Propylene Glycol to the Freshwater Alga Selenastrum capricornutum | Author: ARCO Chemical Company | Year: 1990 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Static Acute Toxicity of Propylene Glycol to the Freshwater Alga Selenastrum capricornutum | Author: ARCO Chemical Company | Year: 1990 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Static acute toxicity of propylene glycol to the marine alga Skeletonema costatum | Author: ARCO Chemical Company | Year: 1990 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Static acute toxicity of propylene glycol to the marine alga Skeletonema costatum | Author: ARCO Chemical Company | Year: 1990 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Chemical substances testing. Final study report: ecotoxicological evaluation of propylene glycol - algal growth inhibition report | Author: The Dow Chemical Company | Year: 1982 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Chemical substances testing. Final study report: ecotoxicological evaluation of propylene glycol - algal growth inhibition report | Author: The Dow Chemical Company | Year: 1982 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Assessment of the sediment-phase toxicity of monopropylene glycol to the amphipod Corophium volutator | Author: National Toxicology Program | Year: 2004 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of Tripropylene Glycol in Rats | Author: Dow Chemical Company | Year: 1995 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism of Tripropylene Glycol in Rats | Author: Dow Chemical Company | Year: 1995 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Monopropylene Glycol: In Vitro Dermal Penetration Rate Testing | Author: Laug EP et al. | Year: 1939 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The toxicology of some glycols and derivatives | Author: Laug EP et al. | Year: 1939 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effect of the inhalation of a surface tension-reducing substance (propylene glycol) on the ultrastructure of the epithelium of the respiratory passages in rabbits | Author: Konradova V Vavrova V Janota J | Year: 1978 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Acute dermal toxicity in albino rabbits | Author: MB Research Laboratories Inc. | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Acute dermal toxicity in albino rabbits | Author: MB Research Laboratories Inc. | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Prufung der akuten Hauttreizwirkung von 12-Propulenglykol. | Author: Hüls | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Prufung der akuten Hauttreizwirkung von 12-Propulenglykol. | Author: Hüls | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: OECD Eye irritation tests on propylene glycol and Solketal | Author: Jacobs GA | Year: 1988 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Comparative study of methods chosen by the Association Fran+ºaise de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig | Author: Guillot JP et al. | Year: 1983 | Guideline: 406, 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea pig maximization test open epicutaneous test and chamber test in induction of delayed contact hypersensitivity | Author: Kero M Hannuksela M | Year: 1980 | Guideline: 406, 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Strategies for identifying false positive responses in predictive skin sensitization tests | Author: Basketter DA et al. | Year: 1998 | Guideline: 406, 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Results of a toxicology study in cats fed diets containing propylene glycol for up to three months. | Author: Toxicology Research Laboratory | Year: 1979 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Results of a toxicology study in cats fed diets containing propylene glycol for up to three months. | Author: Toxicology Research Laboratory | Year: 1979 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Long-term toxicity of propylene glycol in rats. | Author: Gaunt IF et al. | Year: 1972 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Results of feeding propylene glycol in the diet of dogs for two years. | Author: Weil CS et al. | Year: 1971 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: The general properties actions and toxicity of propylene glycol | Author: Seidenfeld MA; Hanzlik PJ | Year: 1932 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats | Author: Suber RL et al. | Year: 1989 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Lack of toxicity and carcinogenicity of some commonly used cutaneous agents | Author: Stenbäck F; Schubik P | Year: 1974 | Guideline: 410 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenic evaluation of compound FDA 71-56. Propylene glycol. | Author: Litton Bionetics Inc. | Year: 1974 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Primary mutagenicity screening of food additives currently used in Japan | Author: Ishidate M et al. | Year: 1984 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs. | Author: Pfeiffer EH; Dunkelberg H | Year: 1980 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Propylene glycol. Metaphase chromosome analysis of human lymphocytes cultured in vitro | Author: Huntingdon Research Centre Ltd | Year: 1990 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Propylene glycol. Metaphase chromosome analysis of human lymphocytes cultured in vitro | Author: Huntingdon Research Centre Ltd | Year: 1990 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenic Evaluation of Compound FDA 71-56 Propylene Glycol. | Author: Litton Bionetics Inc. L | Year: 1974 | Guideline: 483 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. | Author: Hayashi M.; Kishi M; Sofuni T; Ishidate M | Year: 1988 | Guideline: 483 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: NTP Technical Report on the toxicology and carcinogenesis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies) | Author: National Toxicology Program | Year: 2004 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The general properties actions and toxicity of propylene glycol. | Author: Seidenfeld MA; Hanzlik PJ | Year: 1932 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long-term toxicity of propylene glycol in rats. | Author: Gaunt IF et al. | Year: 1972 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Lack of toxicity and carcinogenicity of some commonly used cutaneous agents. | Author: Stenbäck F; Shubik P | Year: 1974 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration | Author: Robertson OH et al. | Year: 1947 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Results of feeding propylene glycol in the diet of dogs for two years. | Author: Weil CS et al. | Year: 1971 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Observations on the chronic toxicities of propylene glycol ethylene glycol diethylene glycol ethylene glycol mono-ethyl -ether and diethylene glycol mono-ethyl-ether | Author: Morris et al. | Year: 1941 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Propylene glycol | Author: National Toxicology Program | Year: 2004 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice | Author: Morrissey RE et al. | Year: 1989 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Propylene glycol: reproduction and fertility assessment in CD-1 mice when administered in drinking water | Author: National Toxicology Program | Year: 1985 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratological evaluation of FDA-71-56 (propylene glycol) in mice rats hamsters and rabbits | Author: Food and Drug Administration | Year: 1973 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of ethylene glycol. | Author: NTP | Year: 2004 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Further evaluation of an in vivo teratology screen | Author: Kavlock RJ; Short RD; Chernoff N | Year: 1987 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Propylene glycol: developmental toxicity gavage study III in CD-1 mice | Author: Bushy Run Research Center | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Propylene glycol: developmental toxicity gavage study III in CD-1 mice | Author: Bushy Run Research Center | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |