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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hazardous Substances Data Bank (HSDB) | Author: HSDB | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: European Union Risk Assessment Report CAS No. 67-66-3 EINECS No. 200-663-8 Chloroform Final Draft | Author: France | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. Inc | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Chloroform | Author: The Merck Index | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. Inc | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. Inc | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Hazardous Substances Data Bank (HSDB) | Author: HSDB | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Laboratory measurements of the aqueous solubility of mixtures of chlorinated solvents. | Author: Broholm K., Feenstra S. | Year: 1995 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: LogKow - a database of evaluated octanol-water partition coefficients (log P) | Author: Sangster J. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Chloroform | Author: Prager J.C. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Chloroform (liquid phase) - dynamic viscosity | Author: Solvay | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Chloroform (liquid phase) - dynamic viscosity | Author: Solvay | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Chloroform | Author: Deshon H.D. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Chloroform | Author: Merck Index | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Chloroform (trichloromethane) fact sheet | Author: Australian Government | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flash point determination of trichloromethane - Equilibrium method closed cup | Author: André D. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flash point determination of trichloromethane - Equilibrium method closed cup | Author: André D. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Zündung durch heisse Oberflächen | Author: Steen H., Gödde M., Bothe H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Zündung durch heisse Oberflächen | Author: Steen H., Gödde M., Bothe H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Pouvoir irritant des principaux solvants chlorés aliphatiques sur la peau et les muqueuses oculaires du lapin | Author: Duprat P., Delsaut L., Gradiski D. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: The toxicity of chloroform as determined by single and repeated exposure of laboratory animals | Author: Torkelson T.R., Oyen F., Rowe V.K. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pouvoir irritant des principaux solvants chlorés aliphatiques sur la peau et les muqueuses oculaires du lapin | Author: Duprat P., Delsaut L., Gradiski D. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: The toxicity of chloroform as determined by single and repeated exposure of laboratory animals | Author: Torkelson T.R., Oyen F., Rowe V.K. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Sensitization test of chloroform: Comparison of guinea pig maximization test (GPMT) and local lymph node assay (LLNA) | Author: Matsuoka C., Kanazawa Y., Kojima K. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Sensitization test of chloroform: Comparison of guinea pig maximization test (GPMT) and local lymph node assay (LLNA) | Author: Matsuoka C., Kanazawa Y., Kojima K. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of carbon tetrachloride and chloroform in Salmonella typhimurium TA98 TA100 TA1535 and TA1537 and Escherichia coli WP2uvrA/pKM101 and WP2/pKM101 using a gas exposure method. | Author: Araki A. et al. | Year: 2004 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli | Author: Kirkland D.L. et al. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Lack of Chloroform-Induced DNA Repair In Vitro and In Vivo in Hepatocytes of Female B6C3F1 Mice. | Author: Larson J.L., Sprankle C.S., Butterworth B.E. | Year: 1994 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Use of primary cultures of human hepatocytes in toxicology studies | Author: Butterworth B.E. et al. | Year: 1989 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of carbon tetrachloride and chloroform in Salmonella typhimurium TA98 TA100 TA1535 and TA1537 and Escherichia coli WP2uvrA/pKM101 and WP2/pKM101 using a gas exposure method. | Author: Araki A. et al. | Year: 2004 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Glutathione S-Transferase-Mediated Mutagenicity of Trihalomethanes in Salmonella typhimurium: Contrasting Results with Bromodichloromethane and Chloroform. | Author: Pegram R.A. et al. | Year: 1997 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Use of the SOS chromotest the Ames-fluctuation test and the newt micronucleus test to study the genotoxicity of four trihalomethanes. | Author: Le Curieux F. et al. | Year: 1995 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Compatibility of organic solvents with the Microscreen prophage-induction assay: solvent - mutagen interactions. | Author: DeMarini D.M. et al. | Year: 1991 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: An association between mutagenicity of the Ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons. | Author: Roldan-Arjona T. et al. | Year: 1991 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: The bacillus subtilis-microsome rec-assay for the detection of DNA damaging substances which may occur in chlorinated and ozonated waters. | Author: Matsui S. et al. | Year: 1989 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic activity of 42 coded compounds in the "microtiter" fluctuation test. | Author: Gatehouse D. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic activity of 42 coded compounds in the Lambda induction assay. | Author: Thomson J.A. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial mutagenicity and cell transformation studies with chloroform. | Author: Daniel M.R. et al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial mutagenicity studies on chloroform in vitro | Author: Van Abbe N.J. et al. | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of constituents identified in pulp and paper mill effluents using the Salmonella-mammalian-microsome assay. | Author: Nestmann E.R. at al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chloroform and carbon tetrachloride induce intrachromosomal recombination and oxidative free radicals in Saccharomyces cerevisiae. | Author: Brennan R.J., Schiestl R.H. | Year: 1998 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Toxicology of halogenated aliphatic hydrocarbons: structural and molecular determinants for the disturbance of chromosome segregation and the induction of lipid peroxidation | Author: Crebelli R. et al. | Year: 1995 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genotoxic activity of halogenated aliphatic hydrocarbons in Aspergillus nidulans | Author: Crebelli .R and Carere A. | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: The induction of mitotic chromosome malsegregation in Aspergillus nidulans. Quantitative structure activity relationship (QSAR) analysis with chlorinated aliphatic hydrocarbons | Author: Crebelli R. et al. | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Induction of chromosome malsegregation by halogenated organic solvents in aspergillus nidulans: Unspecific or specific mechanism? | Author: Crebelli R. et al. | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of the L5178Y Mouse Lymphoma Cell Mutagenesis Assay: Intralaboratory Results for Sixty-Three Coded Chemicals Tested at SRI International. | Author: Mitchell A.D. et al. | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of the L5178Y Mouse Lymphoma Cell Mutagenesis Assay: Intralaboratory Results for Sixty-Three Coded Chemicals Tested at Litton Bionetics | Author: Myhr B.C., Caspary W.J. | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Chloroform detection of gene mutations in somatic cells in culture HPRT-test with V79 cells | Author: Muller W. | Year: 1987 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Chloroform detection of gene mutations in somatic cells in culture HPRT-test with V79 cells | Author: Muller W. | Year: 1987 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Spindle disturbances in mammalian cells. III - Toxicity c-mitosis and aneuploidy with 22 different compounds: Specific and unspecific mechanisms. | Author: Onfelt A. | Year: 1987 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: C-mitosis chromosomal aberrations and sister chromatid exchanges induced bu chloroform in root-tip cells of Allium cepa | Author: Cortés F. et al. | Year: 1985 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Induction of somatic segregation by halogenated aliphatic hydrocarbons in Aspergillus nidulans. | Author: Crebelli R. et al. | Year: 1984 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genotoxic activity of selected chemical carcinogens in Aspergillus nidulans | Author: Carere A. et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genotoxicity of the free-radical producers CCl4 and lipoperoxide in Aspergillus nidulans | Author: Gualandi G. | Year: 1984 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic activity of 42 encoded compounds in the haploid yeast reversion assay strain XV185-14C. | Author: Mehta R.D. and von Borstel R.C. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Induction of Mitotic Gene Conversion by 41 Coded Compounds Using the Yeast Culture JD1. | Author: Sharp D.C. and Parry J.M. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Induction of mitotic gene conversion in strain D7 of saccharomyces cerevisiae by 42 coded chemicals. | Author: Zimmermann F.K. and Scheel I. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Cytochrome P-450 mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in saccharomyces cerevisiae. | Author: Callen D.F. et al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Activity of 40 Coded Compounds in Differential Inhibition and Mitotic Crossing Over Assays in Yeast. | Author: Kassinova G.V. et al. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli | Author: Kirkland D.L. et al. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Sister-chromatid exchanges induced by trihalomethanes in rat erythroblastic cells and their suppression by crude catechin extracted from green tea. | Author: Fujie K. et al. | Year: 1993 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: The evaluation of genotoxicity using DNA repairing test for chemicals produced in chlorination and ozonation processes. | Author: Ono Y., Somiya I., Kawamura M. | Year: 1991 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Induction of sister-chromatid exchanges by direct and indirect mutagens in human lymphocytes co-cultured with intact rat liver cells Effect of enzyme induction and preservation of the liver cells by freezing in liquid nitrogen | Author: Lindahl-Kiessling K., Karlberg .I and Olofsson A.M. | Year: 1989 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: OS-inducing activity of chemical carcinogens and mutagens in salmonella typhimurium TA1535-pSK1002: Examination with 151 chemicals | Author: Nakamura S.I. et al. | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: The SOS chromotest a colorimetric bacterial assay for genotoxins validation study with 83 compounds. | Author: Quillardet P. et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Status of enhancement of DNA viral transformation for determination of mutagenic and carcinogenic potential of gaseous and volatile compounds. | Author: Hatch G. et al. | Year: 1983 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Chemical Enhancement of Viral Transformation in Syrian Hamster Embryo Cells by Gaseous and Volatile Chlorinated Methanes and Ethanes. | Author: Hatch G.G. et al. | Year: 1983 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Trihalomethanes Induce Sister Chromatid Exchanges in Human Lymphocytes in Vitro and Mouse Bone Marrow Cells in Vivo. | Author: Morimoto K. and Koizumi A. | Year: 1983 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of the alkaline elution-rat hepatocyte assay as a predictor of carcinogenic-mutagenic potential | Author: Sina J.F. et al. | Year: 1983 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Chemical Quantification of Unscheduled DNA Synthesis in Cultured Hepatocytes as an Assay for the Rapid Screening of Potential Chemical Carcinogens | Author: Althaus F.R. et al. | Year: 1982 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: DNA damage by haloalkanes in human lymphocytes cultured in vitro | Author: Perocco P. and Prodi G. | Year: 1981 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of micronuclei in the bone marrow of treated rats following 5 days of repeat oral dosing | Author: Whitwell J. | Year: 2009 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Evaluation of micronuclei in the bone marrow of treated rats following 5 days of repeat oral dosing | Author: Whitwell J. | Year: 2009 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay | Author: Mirsalis J.C. et al. | Year: 1982 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Long-Term Mutagenicity Studies With Chloroform and Dimethylnitrosamine in Female lacI Transgenic B6C3F1 Mice | Author: Butterworth B.E. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutant frequencies in livers of female lacI transgenic "big blue" B6C3F1 mice following chloroform inhalation | Author: Templin M.V. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics | Author: Robbiano L. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Lack of Chloroform-Induced DNA Repair In Vitro and In Vivo in Hepatocytes of Female B6C3F1 Mice. | Author: Larson J.L. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity of cosmetics ingredients licensed by the European Communities | Author: Gocke E. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenic activity of 41 compounds in the in vivo micronucleus assay | Author: Salamone M.F., Heddle J.A., Katz M. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Acute and subacute cytogenetic effects of the trihalomethanes on rat bone marrow cells in vivo | Author: Fujie K., Aoki T. and Wada M. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Effects of four trihalomethanes on DNA strand breaks renal hyaline droplet formation and serum testosterone in male F-344 rats | Author: Potters C.L. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparison of Results From Mouse Bone Marrow Chromosome Aberration and Micronucleus Tests. | Author: Shelby M.D. and Witt K.L. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparison of Results From Mouse Bone Marrow Chromosome Aberration and Micronucleus Tests. | Author: Shelby M.D. and Witt K.L. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Amphibian micronucleus test(s) : a simple and reliable method for evaluating in vivo genotoxic effetcs of freshwater pollutants and radiations. Initial assessment | Author: Fernandez M. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Use of the SOS chromotest the Ames-fluctuation test and the newt micronucleus test to study the genotoxicity of four trihalomethanes. | Author: Le Curieux F. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination. | Author: Vogel E.W. and Nivard M.J.M. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic assays for mitotic poisons. The grasshopper embryo system for volatile liquids | Author: Liang J.C. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Trihalomethanes Induce Sister Chromatid Exchanges in Human Lymphocytes in Vitro and Mouse Bone Marrow Cells in Vivo. | Author: Morimoto K. and Koizumi A. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Trihalomethanes as Initiators and Promoters of Carcinogenesis | Author: Pereira M.A. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Trihalomethanes as Initiators and Promoters of Carcinogenesis | Author: Pereira M.A. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mechanistic Considerations for Carcinogenic Risk Estimation: Chloroform | Author: Reitz R.H. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity of cosmetics ingredients licensed by the European Communities | Author: Gocke E. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Activity of coded compounds in the micronucleus test. | Author: Tsuchimoto T. and Matter B.E. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenic activity of 17 coded compounds in the sex-linked recessive lethal test in Drosophila melanogaster | Author: Vogel E. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Covalent binding of chloroform metabolites to nuclear proteins - No evidence for binding to nucleic acids. | Author: Diaz-Gomez M.I. and Castro J.A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens? | Author: Topham J.C. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The acute toxicity of four trihalomethanes in male and female rats | Author: Chu I. et al. | Year: 1980 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Comparison of chloroform-induced toxicity in kidneys liver and nasal passages of Osborne-Mendel and F-344 rats | Author: Templin M.V. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Comparison of chloroform-induced toxicity in the kidneys liver and nasal passages of male Osborne-Mendel and F-344 rats | Author: Templin M.V. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: NOAEL and LOAEL determinations of acute hepatotoxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F344 rats | Author: Keegan T.E. et al. | Year: 1998 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water | Author: Larson J.L. et al. | Year: 1995 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water | Author: Larson J.L. et al. | Year: 1995 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Détermination de la concentration léthale50 des principaux hydrocarbures aliphatiques chlorés chez le rat | Author: Bonnet P. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toxicité aiguë comparée par inhalation des principaux solvants aliphatiques chlorés | Author: Gradiski D. et al. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Safety evaluation of toothpaste containing chloroform III. Long-term study in Beagle dogs | Author: Heywood R. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicity and cell proliferation in the liver kidneys and nasal passages of female F-344 rats induced by chloroform administered by gavage | Author: Larson J.L. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water | Author: Larson J.L. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: comparison of administration by gavage in corn oil vs ad libitum in drinking water | Author: Larson J.L. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Induced cytolethality and regenerative cell proliferation in the livers and kidneys of male B6C3F1 mice given chlorform by gavage | Author: Larson J.L. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Comparative renal and hepatotoxicity of halomethanes: bromodichloromethane bromoform chloroform dibromochloromethane and methylene chloride | Author: Condie L.W. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: implications for chloroform carcinogenesis | Author: Bull R.J. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicology of organic drinking water contaminants: trichloromethane bromodichloromethane dibromochloromethane and tribromoethane | Author: Munson A.E. et al. | Year: 1982 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 90-day chloroform inhalation study in female and male B6C3F1 mice: implications for cancer risk assessment | Author: Larson J.L. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Patterns of chloroform-induced regenerative cell proliferation in BDF1 mice correlate with organ specificity and dose-response of tumor formation | Author: Templin M.V. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies | Author: Templin M.V. et al. | Year: 1996 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Acute and subchronic inhalation toxicity of chloroform in rats and mice | Author: Kasai T. et al. | Year: 2002 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Acute and subchronic inhalation toxicity of chloroform in rats and mice | Author: Kasai T. et al. | Year: 2002 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation | Author: Yamamoto S. et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation | Author: Yamamoto S. et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chloroform: Supplementary Inhalation Embryotoxicity Study in Wistar Rats | Author: Baeder C., Hofmann T. | Year: 1991 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Chloroform: Supplementary Inhalation Embryotoxicity Study in Wistar Rats | Author: Baeder C., Hofmann T. | Year: 1991 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chlorofom - Prüfung auf embryotoxische Wirkung an Wistar-Ratten bei inhalativer Verabreichung | Author: Baeder C., Hofmann T. | Year: 1988 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Chlorofom - Prüfung auf embryotoxische Wirkung an Wistar-Ratten bei inhalativer Verabreichung | Author: Baeder C., Hofmann T. | Year: 1988 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Embryo- and fetotoxicity of inhaled chloroform in rats | Author: Schwetz B.A., Leong B.J.K., Gehring P.J. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Toxicity of inhaled chloroform in pregnant mice and their offspring | Author: Murray F.J. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratology studies on orally administered chloroform in the rat and rabbit | Author: Thompson D.J., Warner S.D., Robinson V.B. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratology studies on orally administered chloroform in the rat and rabbit | Author: Thompson D.J., Warner S.D., Robinson V.B. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A teratological assessment of four trihalomethanes in the rat | Author: Ruddick J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chloroform (CAS No. 67-66-3) | Author: Chapin R. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chloroform: Reproduction and fertility assessment in CD-1 mice when administered by gavage | Author: NTP | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Effect of selected organic drinking water contaminants on male reproduction. | Author: Borzelleca J.F., Carchman R.A. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Behavioral teratology evaluation of trichloromethane in mice | Author: Burkhalter J.E., Balster R.L. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Behavioral toxicity of trihalomethane contaminants of drinking water in mice | Author: Balster R.L., Borzelleca J.F. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation | Author: Yamamoto S. et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Safety evaluation of toothpaste containing chloroform I. Long-term studies in mice | Author: Roe F.J.C. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Report on the carcinogenesis bioassay of chloroform | Author: NCI National Cancer Institute | Year: 1976 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice | Author: Jorgenson T.A. et al. | Year: 1985 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Report on the carcinogenesis bioassay of chloroform | Author: NCI National Cancer Institute | Year: 1976 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity of chloroform and bromodichloromethane when administered over a lifetime in rats | Author: Tumasonis C.F., McMartin D.N., Bush B. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Safety evaluation of toothpaste containing chloroform III. Long-term study in Beagle dogs | Author: Heywood R. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Toxische Schädigung der Leber durch Chloroform bei Chemiebetriebswerkern | Author: Bomski H., Sobolewska A., Strakowski A. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Studies on the toxicity and maximum allowable concentration of chloroform | Author: Li L.H. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Pregnancy outcome of personnel in Swedish biomedical research laboratories | Author: Wennborg H. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: The association of waterborne chloroform with intrauterine growth retardation | Author: Kramer M.D. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: A 90-day chloroform inhalation study in female and male B6C3F1 mice: implications for cancer risk assessment | Author: Larson J.L. et al. | Year: 1996 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies | Author: Templin M.V. et al. | Year: 1996 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Acute and subchronic inhalation toxicity of chloroform in rats and mice | Author: Kasai T. et al. | Year: 2002 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Nasal toxicity of chloroform in male F-344 rats and female B6C3F1 mice following 1-week inhalation exposure | Author: Méry S. et al. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Testung wassergefährdender Stoffe als Grundlage für Wasserqualitätsstandards | Author: Röderer G. | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: A study to assess the influence of age on the response of fathead minnows in static acute toxicity tests | Author: Mayes M.A., Alexander H.C., Dill D.C. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicity and bioaccumulation of chloroform to four species of freshwater fish | Author: Anderson D.R., Lustry E.B. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity and bioaccumulation of chloroform to four species of freshwater fish | Author: Anderson D.R., Lustry E.B. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) Volume V | Author: Geiger D.L., Brooke L.T., Call D.J. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Quantitative structure-activity relationships in fish toxicity studies. Part 1: relationship for 50 industrial pollutants | Author: Könemann H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Report on a study to assess the toxicity of chloroform to oyster (Crassostrea gigas) embryos. | Author: Johnson I., Harman M. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Report on a study to assess the toxicity of chloroform to oyster (Crassostrea gigas) embryos. | Author: Johnson I., Harman M. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of priority pollutants to water flea (Daphnia magna) | Author: LeBlanc G.A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute lethal toxicity of hydrocarbons and chlorinated hydrocarbons to two plankton crustaceans: the key role of organism-water partitioning | Author: Abernethy S. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Results of the harmful effects of water pollutants to Daphnia magna in the 21 day reproduction test | Author: Kühn R. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity testing of highly volatile chemicals with green algae | Author: Brack W., Rottler H. | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G., Kühn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Testing of substances for their toxicity threshold: model organisms Microcystis (Diplocystis) aeruginosa and Scenedesmus quadricauda | Author: Bringmann G., Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Vom Wasser 50 45-60 | Author: Bringmann G., Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Comparison of the toxicity thresholds of water pollutants to bacteria algae and protozoa in the cell multiplication inhibition test | Author: Bringmann G., Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe aus der Hemmung der|Zellvermehrung der Blaualge Microcystis | Author: Bringmann G. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Vergleichende Befunde der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Blaualgen (Microcystis aeruginosa) | Author: Bringmann G., Kühn R. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G., Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Results of the harmful effects of water pollutants to green algae (Scenedesmus subspicatus) in the cell multiplication inhibition test | Author: Kühn R., Pattard M. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: A database of chemical toxicity to environmental bacteria and its use in interspecies comparisons and correlations | Author: Blum D.J., Speece R.E. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: A database of chemical toxicity to environmental bacteria and its use in interspecies comparisons and correlations | Author: Blum D.J., Speece R.E. | Year: 1991 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: A database of chemical toxicity to environmental bacteria and its use in interspecies comparisons and correlations | Author: Blum D.J., Speece R.E. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Vergleichende Befunde der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Blaualgen (Microcytis aeruginosa) | Author: Bringmann G., Kühn R. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparison of the toxicity thresholds of water pollutants to bacteria algae and protozoa in the cell multiplication inhibition test | Author: Bringmann G., Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen III. Saprozoische Flagellaten | Author: Bringmann G., Kühn R., Winter A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparison of three rapid toxicity test procedures: Microtox Polytox and activated sludge respiration inhibition | Author: Elnabarawy M.T., Robideau R.R., Beach S.A. | Year: 1988 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Chronic toxicity of chloroform to Japanese Medaka fish | Author: Toussaint M.W. et al. | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Results of the harmful effects of water pollutants to Daphnia magna in the 21 day reproduction test | Author: Kühn R. et al. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Biodegradation and bioaccumulation data of existing chemicals based on the Chemical Substances Control Law (CSCL) Japan. | Author: Ministry of International Trade and Industry (MITI) Japan | Year: 1992 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Biodegradation and bioaccumulation data of existing chemicals based on the Chemical Substances Control Law (CSCL) Japan. | Author: Ministry of International Trade and Industry (MITI) | Year: 1992 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Acute toxicity and bioaccumulation of chloroform to four species of freshwater fish | Author: Anderson D.R., Lustry E.B. | Year: 1980 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Prediction of algal bioaccumulation and uptake rate of nine organic compounds by ten physicochemical properties | Author: Mailhot H. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Chloroform: sediment ecotoxicity testing with the midge Chironomus riparius using spiked sediment in a flow-through sediment-water system | Author: Woodburn K.B. et al. | Year: 2006 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Chloroform: sediment ecotoxicity testing with the midge Chironomus riparius using spiked sediment in a flow-through sediment-water system | Author: Woodburn K.B. et al. | Year: 2006 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Chloroform: sediment ecotoxicity testing with the oligochaete Lumbriculus variegatus using spiked sediment in a flow-through sediment-water system | Author: Woodburn K.B. et al. | Year: 2006 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Chloroform: sediment ecotoxicity testing with the oligochaete Lumbriculus variegatus using spiked sediment in a flow-through sediment-water system | Author: Woodburn K.B. et al. | Year: 2006 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Toxic effects of pollutants on methane production in sediments of the River Rhine | Author: van Vlaardingen P.L.A., van Beelen P. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Homogeneous hydrolysis rate constants for selected chlorinated methanes ethanes ethenes and propanes | Author: Jeffers P.M. et al. | Year: 1989 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis rates of dissolved volatile organic compounds: principles temperature effects and literature review | Author: Washington J.W. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Evaporation rates and reactivities of methylene chloride chloroform 111-trichloroethane Trichloroethylene Tetrachloroethylene and other chlorinated compounds in dilute aqueous solutions | Author: Dilling W.L., Tefertiller N.B., Kallos G.J. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and bioaccumulation data of existing chemicals based on the Chemical Substances Control Law (CSCL) Japan. | Author: Ministry of International Trade and Industry (MITI) Japan | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Anaerobic degradation of halogenated 1- and 2-carbon organic compounds | Author: Bouwer E.J., Rittmann B.E., McCarty P.L. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Anaerobic degradation of halogenated 1- and 2-carbon organic compounds | Author: Bouwer E.J., Rittmann B.E., McCarty P.L. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Chloroform sorption to New Jersey coastal plain ground water aquifer solids | Author: Uchrin C.G., Mangels G. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Chloroform sorption to New Jersey coastal plain ground water aquifer solids | Author: Uchrin C.G., Mangels G. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Influence of organic matter from soils and sediments from various origins on the sorption of some chlorinated aliphatic hydrocarbons: implications on Koc correlations | Author: Gratwohl P. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Transport and fate of selected organic pollutants in a sandy soil | Author: Wilson J.T. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: The mineralization of chloroform in river sediments | Author: van Beelen P., van Vlaardingen P.L.A. | Year: 1993 | Guideline: 308 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: The kinetics of the degradation of chloroform and benzene in anaerobic sediment from the River Rhine | Author: van Beelen .,P van Keulen F. | Year: 1990 | Guideline: 308 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Chlorinated C1 and C2 hydrocarbons in the marine environment | Author: Pearson C.R., McConnell G. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Testing of the abiotic degradation of chemicals in the atmosphere: the smog chamber approach | Author: Klöpffer W. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Measurements of some potentially hazardous organic chemicals in urban environments | Author: Singh H.B. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Photoproduction of hyrated electrons from natural organic solutes in aquatic environments | Author: Zepp R.G. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Evaporation rates and reactivities of methylene chlorid chloroform 111-trichloroethane trichloroethylene tetrachloroethylene and other chlorinated compounds in dilute aqueous solutions | Author: Dilling W.L. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Impact of chloroform exposures on reproductive and developmental outcomes: A systematic review of the scientific literature. | Author: Williams A.L. et al. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Toxische Schädigung der Leber durch Chloroform bei Chemiebetriebswerkern | Author: Bomski H., Sobolewska A., Strakowski A. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Studies on the toxicity and maximum allowable concentration of chloroform | Author: Li L.H. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |