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CAS 67-66-3 | Data Package 1 - 10 t/a

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Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Hazardous Substances Data Bank (HSDB) | Author: HSDB | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: European Union Risk Assessment Report CAS No. 67-66-3 EINECS No. 200-663-8 Chloroform Final Draft | Author: France | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. Inc | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Chloroform | Author: The Merck Index | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. Inc | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Boiling point Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. Inc | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Density Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Surface tension Robust Study Summary -- Title: Hazardous Substances Data Bank (HSDB) | Author: HSDB | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Laboratory measurements of the aqueous solubility of mixtures of chlorinated solvents. | Author: Broholm K., Feenstra S. | Year: 1995 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Chloroform | Author: Verschueren K. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: LogKow - a database of evaluated octanol-water partition coefficients (log P) | Author: Sangster J. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Phys-Chem | Flash point Robust Study Summary -- Title: Flash point determination of trichloromethane - Equilibrium method closed cup | Author: André D. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Right to refer to study -- Title: Flash point determination of trichloromethane - Equilibrium method closed cup | Author: André D. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Zündung durch heisse Oberflächen | Author: Steen H., Gödde M., Bothe H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Zündung durch heisse Oberflächen | Author: Steen H., Gödde M., Bothe H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Sensitization test of chloroform: Comparison of guinea pig maximization test (GPMT) and local lymph node assay (LLNA) | Author: Matsuoka C., Kanazawa Y., Kojima K. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Sensitization test of chloroform: Comparison of guinea pig maximization test (GPMT) and local lymph node assay (LLNA) | Author: Matsuoka C., Kanazawa Y., Kojima K. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity of carbon tetrachloride and chloroform in Salmonella typhimurium TA98 TA100 TA1535 and TA1537 and Escherichia coli WP2uvrA/pKM101 and WP2/pKM101 using a gas exposure method. | Author: Araki A. et al. | Year: 2004 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli | Author: Kirkland D.L. et al. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity of carbon tetrachloride and chloroform in Salmonella typhimurium TA98 TA100 TA1535 and TA1537 and Escherichia coli WP2uvrA/pKM101 and WP2/pKM101 using a gas exposure method. | Author: Araki A. et al. | Year: 2004 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Glutathione S-Transferase-Mediated Mutagenicity of Trihalomethanes in Salmonella typhimurium: Contrasting Results with Bromodichloromethane and Chloroform. | Author: Pegram R.A. et al. | Year: 1997 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Use of the SOS chromotest the Ames-fluctuation test and the newt micronucleus test to study the genotoxicity of four trihalomethanes. | Author: Le Curieux F. et al. | Year: 1995 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Compatibility of organic solvents with the Microscreen prophage-induction assay: solvent - mutagen interactions. | Author: DeMarini D.M. et al. | Year: 1991 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: An association between mutagenicity of the Ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons. | Author: Roldan-Arjona T. et al. | Year: 1991 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: The bacillus subtilis-microsome rec-assay for the detection of DNA damaging substances which may occur in chlorinated and ozonated waters. | Author: Matsui S. et al. | Year: 1989 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenic activity of 42 coded compounds in the "microtiter" fluctuation test. | Author: Gatehouse D. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenic activity of 42 coded compounds in the Lambda induction assay. | Author: Thomson J.A. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Bacterial mutagenicity and cell transformation studies with chloroform. | Author: Daniel M.R. et al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Bacterial mutagenicity studies on chloroform in vitro | Author: Van Abbe N.J. et al. | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity of constituents identified in pulp and paper mill effluents using the Salmonella-mammalian-microsome assay. | Author: Nestmann E.R. at al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Chloroform and carbon tetrachloride induce intrachromosomal recombination and oxidative free radicals in Saccharomyces cerevisiae. | Author: Brennan R.J., Schiestl R.H. | Year: 1998 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Toxicology of halogenated aliphatic hydrocarbons: structural and molecular determinants for the disturbance of chromosome segregation and the induction of lipid peroxidation | Author: Crebelli R. et al. | Year: 1995 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Genotoxic activity of halogenated aliphatic hydrocarbons in Aspergillus nidulans | Author: Crebelli .R and Carere A. | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: The induction of mitotic chromosome malsegregation in Aspergillus nidulans. Quantitative structure activity relationship (QSAR) analysis with chlorinated aliphatic hydrocarbons | Author: Crebelli R. et al. | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Induction of chromosome malsegregation by halogenated organic solvents in aspergillus nidulans: Unspecific or specific mechanism? | Author: Crebelli R. et al. | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Induction of somatic segregation by halogenated aliphatic hydrocarbons in Aspergillus nidulans. | Author: Crebelli R. et al. | Year: 1984 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Genotoxic activity of selected chemical carcinogens in Aspergillus nidulans | Author: Carere A. et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Genotoxicity of the free-radical producers CCl4 and lipoperoxide in Aspergillus nidulans | Author: Gualandi G. | Year: 1984 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenic activity of 42 encoded compounds in the haploid yeast reversion assay strain XV185-14C. | Author: Mehta R.D. and von Borstel R.C. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Induction of Mitotic Gene Conversion by 41 Coded Compounds Using the Yeast Culture JD1. | Author: Sharp D.C. and Parry J.M. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Induction of mitotic gene conversion in strain D7 of saccharomyces cerevisiae by 42 coded chemicals. | Author: Zimmermann F.K. and Scheel I. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Cytochrome P-450 mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in saccharomyces cerevisiae. | Author: Callen D.F. et al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Activity of 40 Coded Compounds in Differential Inhibition and Mitotic Crossing Over Assays in Yeast. | Author: Kassinova G.V. et al. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli | Author: Kirkland D.L. et al. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: OS-inducing activity of chemical carcinogens and mutagens in salmonella typhimurium TA1535-pSK1002: Examination with 151 chemicals | Author: Nakamura S.I. et al. | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: The SOS chromotest a colorimetric bacterial assay for genotoxins validation study with 83 compounds. | Author: Quillardet P. et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: The acute toxicity of four trihalomethanes in male and female rats | Author: Chu I. et al. | Year: 1980 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Comparison of chloroform-induced toxicity in kidneys liver and nasal passages of Osborne-Mendel and F-344 rats | Author: Templin M.V. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Comparison of chloroform-induced toxicity in the kidneys liver and nasal passages of male Osborne-Mendel and F-344 rats | Author: Templin M.V. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: NOAEL and LOAEL determinations of acute hepatotoxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F344 rats | Author: Keegan T.E. et al. | Year: 1998 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water | Author: Larson J.L. et al. | Year: 1995 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water | Author: Larson J.L. et al. | Year: 1995 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Report on a study to assess the toxicity of chloroform to oyster (Crassostrea gigas) embryos. | Author: Johnson I., Harman M. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Report on a study to assess the toxicity of chloroform to oyster (Crassostrea gigas) embryos. | Author: Johnson I., Harman M. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute toxicity of priority pollutants to water flea (Daphnia magna) | Author: LeBlanc G.A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute lethal toxicity of hydrocarbons and chlorinated hydrocarbons to two plankton crustaceans: the key role of organism-water partitioning | Author: Abernethy S. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Results of the harmful effects of water pollutants to Daphnia magna in the 21 day reproduction test | Author: Kühn R. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Toxicity testing of highly volatile chemicals with green algae | Author: Brack W., Rottler H. | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G., Kühn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Testing of substances for their toxicity threshold: model organisms Microcystis (Diplocystis) aeruginosa and Scenedesmus quadricauda | Author: Bringmann G., Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Vom Wasser 50 45-60 | Author: Bringmann G., Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Comparison of the toxicity thresholds of water pollutants to bacteria algae and protozoa in the cell multiplication inhibition test | Author: Bringmann G., Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe aus der Hemmung der|Zellvermehrung der Blaualge Microcystis | Author: Bringmann G. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Vergleichende Befunde der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Blaualgen (Microcystis aeruginosa) | Author: Bringmann G., Kühn R. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G., Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Results of the harmful effects of water pollutants to green algae (Scenedesmus subspicatus) in the cell multiplication inhibition test | Author: Kühn R., Pattard M. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation and bioaccumulation data of existing chemicals based on the Chemical Substances Control Law (CSCL) Japan. | Author: Ministry of International Trade and Industry (MITI) Japan | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Anaerobic degradation of halogenated 1- and 2-carbon organic compounds | Author: Bouwer E.J., Rittmann B.E., McCarty P.L. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Anaerobic degradation of halogenated 1- and 2-carbon organic compounds | Author: Bouwer E.J., Rittmann B.E., McCarty P.L. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -