You are here: Home> Turkey>TR-REACH>CAS 69-72-7> CAS 69-72-7 | Data Package 1 - 10 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Remington's pharmaceutical sciences 18th ed. | Author: Gennaro A.R. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate | Author: Cosmetic Ingredients Review Expert Panel (Fiume MZ) | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's condensed chemical dictionary 12th ed. | Author: Lewis R.J. Sr. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CFTA compendium of cosmetic ingredient composition - specifications | Author: Nikitakis J.M., McEwan G.N., Jr Eds | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics. 71th ed. | Author: Lide D.R. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Illustrated handbook of physical-chemical properties and environmental fate for organic chemicals: Vol IV | Author: Mackay D., Shiu W.Y., Ma K.C. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Dictionary of Substances and their Effects 2nd ed. Vol. 6. Ed. Gangolli S Richardson M | Author: Gangolli S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Lewis R.J. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of environmental data on organic chemicals. 2nd ed | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Mesures granulométriques de l'acide salicylique | Author: Gras G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Right to refer to study -- Title: Mesures granulométriques de l'acide salicylique | Author: Gras G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Right to refer to study -- Title: Mesures granulométriques de l'acide salicylique | Author: Gras G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Mackay D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: Mackay D., Shiu W.Y., Ma K.C. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Atomic physicochemical parameters for three-dimensional|structure-directed quantitative structure-activity|relationships I : Partition coefficients as a measure of|hydrophobicity. | Author: Ghose A.K. and Crippen G.M. | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: The treatment of Ionizable Compounds in Quantitative Structure-Activity Studies with Special Consideration to Ion Partitioning | Author: Scherrer R.A. | Year: 1986 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Partition coefficients and their uses. | Author: Leo A., Hansch C. & Elkins D. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Some physical factors in toxicological assessment tests. | Author: Freed V.H. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Development of a general QSAR for predicting octanol-water partition coefficients and its application to surfactants. | Author: Moschner K.F. and Cece A. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Accurate wide-range automated high-performance liquid chromatographic method for the estimation of octanol/water partition coefficients : Effect of chromatographic conditions and procedure variables on accuracy and reproducibility of the method. | Author: Garst J.E. and Wilson W.C. | Year: 1984 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation of the partitioning characteristics of drugs : a comparison of a large and diverse drug series utilizing chromatographic and electrophoretic methodology | Author: Hanna M. et al. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: Gangolli S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Comparative toxicity and structure-activity in Chlorella and|Tetrahymena : monosubstituted phenols. | Author: Jaworska J.S. and Schultz T.W. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Quantitative structure-activity relationships for the toxicity to the Tadpole Rana japonica of selected phenols. | Author: Wang X. et al. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: The effects of ionization on partition coefficients and topical delivery. | Author: Loftsson T. | Year: 1985 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Die pH-abhängige " Lipidlöslichkeit" von Arzneistoffen | Author: Le Petit G. | Year: 1977 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Correlation between the growth inhibitory effects partition|coefficients ans teratogenic effects of lipophilic acids. | Author: Freese E. et al. | Year: 1979 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Group contribution methods to estimate water solubility of organic chemicals. | Author: Kühne R. et al. | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Gangolli S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Some physical factors in toxicological assessment tests. | Author: Freed V.H., Chiou C.T., Schmeding D. and Kohnert R. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Mackay D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: No information | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: No information | Author: Boullard O. et al. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Acide salicylique : explosivité des poussières. | Author: Heinisch B. | Year: 1986 | Guideline: BAM test | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Acide salicylique : explosivité des poussières. | Author: Heinisch B. | Year: 1986 | Guideline: BAM test | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Safety relevant data of SAS 500kg (FXG03NP) | Author: Keldenich H.P. | Year: 2010 | Guideline: UN test procedure N1(§ 33.2.1.4) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Safety relevant data of SAS 500kg (FXG03NP) | Author: Keldenich H.P. | Year: 2010 | Guideline: UN test procedure N1(§ 33.2.1.4) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: No information | Author: Mackay D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Correlation between the growth inhibitory effects partition coefficients and teratogenic effects of lipophilic acids. | Author: Freese E. et al. | Year: 1979 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Surface-catalyzed chromium (VI) reduction : reactivity comparisons of different organic reductants and different|oxide surfaces. | Author: Deng B. and Stone A.T. | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Comparative toxicity and structure-activity in Chlorella and Tetrahymena : monosubstituted phenols. | Author: Jaworska J.S. and Schultz T.W. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Budavari S. | Year: 1989 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: No information | Author: Lyman W.J. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: No information | Author: HSDB | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: HSDB | Author: No author provided | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Buxton G.V. et al. | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Acide salicylique : explosivité des poussières. | Author: Heinisch B. | Year: 1986 | Guideline: BAM test | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Anbar M., Neta P. | Year: 1967 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Reactivity of the Hydroxyl Radical in Aqueous Solution | Author: Dorfman L.M., Admas G.E. | Year: 1973 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Salicylic acid Environmental abiotic degradation | Author: No author provided | Year: 2008 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Safety relevant data of SAS 500kg (FXG03NP) | Author: Keldenich H.P. | Year: 2010 | Guideline: UN test procedure N1(§ 33.2.1.4) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Wang W.H. et al. | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Guideline: DIN 38412 part 11 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: 202 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of benzoic acids to the crustacean Daphnia magna | Author: Kamaya Y., Fukaya Y. and Suzuki K. | Year: 2005 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: Palla J.C., Dion M. | Year: 1983 | Guideline: AFNOR T 9030 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: Palla J.C., Dion M. | Year: 1983 | Guideline: AFNOR T 9030 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Fate and effects of salicylic acid compounds in freshwater systems. | Author: Wang W.H., Lay J.P. | Year: 1989 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Life-History Traits of Standard and Autochthonous Cladocerans: II. Acute and Chronic Effects of Acetylsalicylic Acid Metabolites | Author: Marques C.R., Abrantes N., Goncalves F. | Year: 2004 | Guideline: 202 | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse des Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickelten standardisieten Testverfahren. | Author: Bringmann G., Kühn R. | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: D. Decros | Year: 1984 | Guideline: AFNOR T 90301 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: D. Decros | Year: 1984 | Guideline: AFNOR T 90301 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Fate and effects of salicylic acid compounds in freshwater systems. | Author: Wang W.H., Lay J.P. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Comparative toxicity and structure-activity in Chlorella and Tetrahymena : monosubstituted phenols. | Author: Jaworska J.S. and Schultz T.W. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of isomers of hydroxybenzoic acid on the growth and metabolism of Chlorella Vulgaris Beijerinck (Chlorophyceae) | Author: Czerpak R., Bajguz A., Piotrowska A., Polecka M. | Year: 2001 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Use of Lemna minor L. as a bioassay in allelopathy. | Author: Einhellig F.A., Leather G.R. and Hobbs L.L. | Year: 1985 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Qualitative and quantitative characterization of phenolic compounds from Lantana (Lantana camara) leaves. | Author: Jain R., Singh M. and Dezman D.J. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Effects of three phenolic compounds on Lemna gibba G3 | Author: Ramirez Toro G.I., Leather G.R. and Einhellig F.A. | Year: 1988 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: Palla J.C., Dion M. | Year: 1983 | Guideline: AFNOR T 9030 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 | Author: STERNALSKI R. | Year: 1992 | Guideline: Draft of norm ISO/CD 10712 (1990-10-10) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Structure-toxicity assessment of metabolites of the aerobic bacterial transformation of substituted naphtalenes. | Author: Leblond J.D. et al. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells. | Author: Sheu C.W. et al. | Year: 1975 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: DIN 38412-8 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: D. Decros | Year: 1984 | Guideline: AFNOR T 90301 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Guideline: Kuhn test | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Erste Ansätze zur ökologischen Bewertung von Pharmaka in Oberflächengewässern. | Author: Kalbfus W., Kopf W. | Year: 1998 | Guideline: DIN 38412-8 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: draft (Pauli 1996) | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Role of EDTA in a simple method for determining toxicity using a bacterial indicator organism. | Author: Botsford J.L. | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Evaluation of the OECD activated sludge respiration inhibition test. | Author: Klecka G.M. and Landi L.P. | Year: 1985 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Application of the Microtox system to assess the toxicity of pesticides and their hydrolysis metabolites. | Author: Somasundaram L. et al. | Year: 1990 | Guideline: ISO 11348-3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to soil macro-organisms except anthropods | Robust Study Summary -- Title: Effect of aromatic compounds humic acids and lignins on growth of the earthworm Eisenia foetida. | Author: Hartenstein R. | Year: 1982 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Action model of allelopathic compounds on seed germination. Allelochemicals Mycotoxins and Insect Pheromones and Allomones. | Author: Hsu F.H., Chiu C.Y., Chou C.H. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Plant damage caused by antiseptics 2 | Author: Fukushima and Masafumi | Year: 1998 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute toxicity tests on 113 environmental chemicals | Author: Hasegawa R., Nakaji Y., Kurokawa Y., Tobe M. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The international validation study of the acute toxic class method (oral) | Author: Schlede E., Mischke U., Diener W., Kayser D. | Year: 1995 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology profiles on substances used in the FRAME cytotoxicology research project. | Author: Purchase I.F.H., Farrar D.G., Whitaker A.I. | Year: 1987 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Salicylic Acid- Pharmaceutical Grade CAS NB 69-72-7 Primary Skin Irritation Study in Rabbits (4 Hour semi-Occlusive Application) | Author: Arcelin G. | Year: 2008 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Salicylic Acid- Pharmaceutical Grade CAS NB 69-72-7 Primary Skin Irritation Study in Rabbits (4 Hour semi-Occlusive Application) | Author: Arcelin G. | Year: 2008 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Assessment of cutaneous irritation of formaldehyde salicylic acid and sodium sulfate using transdermal laser doppler velocimetry. | Author: Blalock L.E., Montero-Riviere N.A. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Studies on eye irritation caused by chemicals in rabbits II. Structure-activity relationships and in vitro approach to primary eye irritation of salicylates in rabbits. | Author: Sugai S., Murata K., Kitagaki T., Tomita I. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Untitled. | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Untitled. | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (1) Overview of the validation study and Draize scores for the evaluation of the test | Author: Ohno Y. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation. | Author: Basketter D.A. et al. | Year: 1999 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bovine corneal opacity and permeability test: an in vitro assay of ocular irritancy | Author: Gautheron P., Dukic M., Alix D., Sin J.F. | Year: 1992 | Guideline: 437 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Strategies for identifying false positive responses in predictive skin sensitization tests | Author: Basketter D.A., Gerberick G.F., Kimber I. | Year: 1998 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Phenotypic analysis of lymphocyte subpopulations in lymph nodes draining the ear following exposure to contact allergens and irritants. | Author: Sikorsky E.E. et al. | Year: 1996 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits | Author: Webb W.K., Hansen W.H. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Development and validation of an alternative dermal sensitization test : the mouse ear swelling test (MEST). | Author: Gad S.C. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. | Author: Abbott D.D., Harrisson J.W.E. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Examination of the Local Lymph Node Assay for Use in Contact Sensitization Risk Assessment | Author: Gerberick G.F., House R.V., Fletcher E.R., Ryan C.A. | Year: 1992 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Evaluation of lymphocyte proliferation by immunohistochemistry in the lacal lymph node assay | Author: Boussiquet-Leroux C., Durand-Cavagna G., Herlin K., Holder D. | Year: 1992 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: QSAR Study of Skin Sensitization using Local lymph Node Assay Data | Author: Fedorowicz A., Zheng L., Singh H., Demchuk E. | Year: 2004 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mechanism of the lethal and mutagenic effects of phenoxyacetic acids in Saccharomyces cerevisiae. | Author: Zetterberg G. | Year: 1979 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity test data existing chemical substances based on the toxicity investigation system of the industrial safety and health law supplement 2. | Author: Ministry of Labour Japan: Chemical Substance Investigation Division Industrial Safety & Health Department Labour Standard Bureau | Year: 2000 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Salicylic Acid- Pharmaceutical Grade CAS NB 69-72-7 Primary Skin Irritation Study in Rabbits (4 Hour semi-Occlusive Application) | Author: Arcelin G. | Year: 2008 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Survey of chemicals for mutagenic action on E. coli. | Author: Demerec M., Bertani G., Flint J. | Year: 1951 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Absence of mutagenic activity of benorylate paracetamol and acetylsalicylic acid in the Salmonella/mammalian cell cultures. | Author: Jasiewicz M.L., Richardson J.C. | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chromosal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens | Author: Ishidate M., Jr Sofuni T., Yoshikawa K. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of 80 chemicals in Escherichia coli tester strains IC203 deficient in OxyR and its oxyR+ parent WP2 uvrA/pKM101: detection of 31 oxidative mutagens | Author: Martinez A., Urios A., Blanco M. | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. | Author: McCann J., Choi E., Yamasaki E., Ames B. | Year: 1975 | Guideline: 471 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells | Author: Sheu C.W. et al. | Year: 1975 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Untitled. | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. | Author: Ishidate M., Harnois M.C., Sofuni T. | Year: 1988 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Euglena gracilis as an eukaryotic test organism for detecting mutagens and antimutagens | Author: Foltinova P.,Grones J. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Pharmacological studies on the mutagenicity : I. Analgesics and antiinflammatory drugs and their derivatives. | Author: Tamura T., Fujii A., Kuboyama N. | Year: 1980 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice. | Author: Giri A.K., Adhikari N., Khan K.A. | Year: 1996 | Guideline: EPA OPPTS 870.5915 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice. | Author: Giri A.K., Adhikari N., Khan K.A. | Year: 1996 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits | Author: Webb W.K., Hansen W.H. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. | Author: Stoner G.D. et al. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Screening tests of various chemical substances as carcinogenic hazards. | Author: Umeda M. | Year: 1957 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Cocarcinogenic action of acetylsalicylic acid on gastric tumors induced by N-nitroso-N-methylnitro-guanidine in rats | Author: Chang T-H et al. | Year: 1983 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Comparative teratogenicity study of diflunisal (MK-647) and aspirin in the rat | Author: Nakatsuka T., Fujii T. | Year: 1979 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Biochemical mechanisms of salicylate teratology in the rat. | Author: Koshakji R.P., Schulert A.R. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A comparison of forced oral administration and feeding method on the teratogenic effect and fetal distribution of salicylic acid in rats. | Author: Tanaka S. | Year: 1974 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Maternal reproductive effects of oral salicylic acid in Sprague-Dawley rats. | Author: Davis D.P. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chemical exposure of embryos during the preimplantation stages of pregnancy: Mortality rate and intrauterine development | Author: Fabro S., McLachlan J.A., Dames N.M. | Year: 1984 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Postnatal evolution of supernumerary ribs in rats after single administration of sodium salicylate. | Author: Foulon O. et al. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Induction of supernumerary ribs with sodium salicylate. | Author: Foulon O. et al. | Year: 1999 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity interactions of salicylic acid and radiofrequency radiation or 2-methoxyethanol in rats. | Author: Nelson B.K., Snyder D.L., Shaw P.B. | Year: 1999 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |