You are here: Home> Turkey>TR-REACH>CAS 69-72-7> CAS 69-72-7 | Data Package 10 - 100 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Remington's pharmaceutical sciences 18th ed. | Author: Gennaro A.R. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate | Author: Cosmetic Ingredients Review Expert Panel (Fiume MZ) | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's condensed chemical dictionary 12th ed. | Author: Lewis R.J. Sr. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CFTA compendium of cosmetic ingredient composition - specifications | Author: Nikitakis J.M., McEwan G.N., Jr Eds | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics. 71th ed. | Author: Lide D.R. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Illustrated handbook of physical-chemical properties and environmental fate for organic chemicals: Vol IV | Author: Mackay D., Shiu W.Y., Ma K.C. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Dictionary of Substances and their Effects 2nd ed. Vol. 6. Ed. Gangolli S Richardson M | Author: Gangolli S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Lewis R.J. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of environmental data on organic chemicals. 2nd ed | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Mesures granulométriques de l'acide salicylique | Author: Gras G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Right to refer to study -- Title: Mesures granulométriques de l'acide salicylique | Author: Gras G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Right to refer to study -- Title: Mesures granulométriques de l'acide salicylique | Author: Gras G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Mackay D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: Mackay D., Shiu W.Y., Ma K.C. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Atomic physicochemical parameters for three-dimensional|structure-directed quantitative structure-activity|relationships I : Partition coefficients as a measure of|hydrophobicity. | Author: Ghose A.K. and Crippen G.M. | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: The treatment of Ionizable Compounds in Quantitative Structure-Activity Studies with Special Consideration to Ion Partitioning | Author: Scherrer R.A. | Year: 1986 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Partition coefficients and their uses. | Author: Leo A., Hansch C. & Elkins D. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Some physical factors in toxicological assessment tests. | Author: Freed V.H. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Development of a general QSAR for predicting octanol-water partition coefficients and its application to surfactants. | Author: Moschner K.F. and Cece A. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Accurate wide-range automated high-performance liquid chromatographic method for the estimation of octanol/water partition coefficients : Effect of chromatographic conditions and procedure variables on accuracy and reproducibility of the method. | Author: Garst J.E. and Wilson W.C. | Year: 1984 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation of the partitioning characteristics of drugs : a comparison of a large and diverse drug series utilizing chromatographic and electrophoretic methodology | Author: Hanna M. et al. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: Gangolli S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Comparative toxicity and structure-activity in Chlorella and|Tetrahymena : monosubstituted phenols. | Author: Jaworska J.S. and Schultz T.W. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Quantitative structure-activity relationships for the toxicity to the Tadpole Rana japonica of selected phenols. | Author: Wang X. et al. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: The effects of ionization on partition coefficients and topical delivery. | Author: Loftsson T. | Year: 1985 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Die pH-abhängige " Lipidlöslichkeit" von Arzneistoffen | Author: Le Petit G. | Year: 1977 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Correlation between the growth inhibitory effects partition|coefficients ans teratogenic effects of lipophilic acids. | Author: Freese E. et al. | Year: 1979 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Group contribution methods to estimate water solubility of organic chemicals. | Author: Kühne R. et al. | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Gangolli S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Some physical factors in toxicological assessment tests. | Author: Freed V.H., Chiou C.T., Schmeding D. and Kohnert R. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Mackay D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: No information | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: No information | Author: Boullard O. et al. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Acide salicylique : explosivité des poussières. | Author: Heinisch B. | Year: 1986 | Guideline: BAM test | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Acide salicylique : explosivité des poussières. | Author: Heinisch B. | Year: 1986 | Guideline: BAM test | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Safety relevant data of SAS 500kg (FXG03NP) | Author: Keldenich H.P. | Year: 2010 | Guideline: UN test procedure N1(§ 33.2.1.4) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: No information | Author: Sax N.I. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Safety relevant data of SAS 500kg (FXG03NP) | Author: Keldenich H.P. | Year: 2010 | Guideline: UN test procedure N1(§ 33.2.1.4) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: No information | Author: Boullard O., Leblanc H. & Besson B. | Year: 1993 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: No information | Author: Mackay D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Correlation between the growth inhibitory effects partition coefficients and teratogenic effects of lipophilic acids. | Author: Freese E. et al. | Year: 1979 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Surface-catalyzed chromium (VI) reduction : reactivity comparisons of different organic reductants and different|oxide surfaces. | Author: Deng B. and Stone A.T. | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Comparative toxicity and structure-activity in Chlorella and Tetrahymena : monosubstituted phenols. | Author: Jaworska J.S. and Schultz T.W. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Budavari S. | Year: 1989 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: No information | Author: Lyman W.J. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: No information | Author: HSDB | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: HSDB | Author: No author provided | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: No information | Author: De Laat J Bouanga F Dore M & Mallevialle J | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Buxton G.V. et al. | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation of the Adsorption Coefficient (Koc) on Soil using High Performance Liquid Chromatography (HPLC) (OECD Guideline 121). | Author: Groult R. | Year: 2002 | Guideline: 121 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Estimation of the Adsorption Coefficient (Koc) on Soil using High Performance Liquid Chromatography (HPLC) (OECD Guideline 121). | Author: Groult R. | Year: 2002 | Guideline: 121 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Acide salicylique : explosivité des poussières. | Author: Heinisch B. | Year: 1986 | Guideline: BAM test | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Comparative study of the adsorption of organic ligands on aluminum oxide by titration calorimetry. | Author: Benoit P., Hering J.G., Stumm W. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Anbar M., Neta P. | Year: 1967 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Competitive sorption between 13-dichlorobenzene or 24-dichlorophenol and natural aromatic acids in soil organic matter. | Author: Xing B. and Pignatello J. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Reactivity of the Hydroxyl Radical in Aqueous Solution | Author: Dorfman L.M., Admas G.E. | Year: 1973 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Salicylic acid Environmental abiotic degradation | Author: No author provided | Year: 2008 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Safety relevant data of SAS 500kg (FXG03NP) | Author: Keldenich H.P. | Year: 2010 | Guideline: UN test procedure N1(§ 33.2.1.4) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Wang W.H. et al. | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: 212 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) | Author: Geiger D.L et al. | Year: 1985 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Sorption of weak organic acids in soils: clofencet 24-D and salicylic acid. | Author: Dubus I.G., Barriuso E., Calvet R. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Guideline: DIN 38412 part 15 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: The fugacity model level I | Author: Mackay D. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Effect of introducing the carboxyl group into the phenol molecule on toxicity to goldfish. | Author: Gersdorff W.A. | Year: 1943 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity for Fish with Salicylic acid (preparative) | Author: Shi | Guideline: UBA test | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute Toxicity for Fish with Salicylic acid (preparative) | Author: Shi | Guideline: UBA test | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Organic constituents of mutagenic secondary effluents from wastewater treatment plants. | Author: Ellis D.D., Jone C.M., Larson R.A. and Schaeffer D.J. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Guideline: DIN 38412 part 11 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Occurence of drugs in German sewage treatment plants and rivers. | Author: Ternes T.A. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: 202 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Estimation of the Adsorption Coefficient (Koc) on Soil using High Performance Liquid Chromatography (HPLC) (OECD Guideline 121). | Author: Groult R. | Year: 2002 | Guideline: 121 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of benzoic acids to the crustacean Daphnia magna | Author: Kamaya Y., Fukaya Y. and Suzuki K. | Year: 2005 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Simultaneous determination of antiseptics and acidic drugs in sewage and river water. | Author: Ternes T.A., Stumpf M., Scuppert B., Haberer K. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Niedermolekulare Carbonsäuren im Boden in der ungesättigten Zone und im Grundwasser. | Author: Cordt T. and Kussmaul H. | Year: 1990 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: Palla J.C., Dion M. | Year: 1983 | Guideline: AFNOR T 9030 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: New directions in oxidant by-product research : identification and significance. | Author: Christman R.F., Norwood D.L. & Johnson J.D. | Year: 1985 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: Palla J.C., Dion M. | Year: 1983 | Guideline: AFNOR T 9030 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Fate and effects of salicylic acid compounds in freshwater systems. | Author: Wang W.H., Lay J.P. | Year: 1989 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Life-History Traits of Standard and Autochthonous Cladocerans: II. Acute and Chronic Effects of Acetylsalicylic Acid Metabolites | Author: Marques C.R., Abrantes N., Goncalves F. | Year: 2004 | Guideline: 202 | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse des Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickelten standardisieten Testverfahren. | Author: Bringmann G., Kühn R. | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: D. Decros | Year: 1984 | Guideline: AFNOR T 90301 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Fate and effects of salicylic acid compounds in freshwater systems | Author: Wang W.H., Lay J.P. | Year: 1989 | Guideline: 202 part 2 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: D. Decros | Year: 1984 | Guideline: AFNOR T 90301 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Erste Ansätze zur oekologischen Bewertung von Pharmaka in Oberflächengewässern. | Author: Kalbfus W., Kopf W. | Year: 1998 | Guideline: 202 part 2 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Fate and effects of salicylic acid compounds in freshwater systems. | Author: Wang W.H., Lay J.P. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute Toxicity for Fish with Salicylic acid (preparative) | Author: Shi | Guideline: UBA test | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Comparative toxicity and structure-activity in Chlorella and Tetrahymena : monosubstituted phenols. | Author: Jaworska J.S. and Schultz T.W. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of isomers of hydroxybenzoic acid on the growth and metabolism of Chlorella Vulgaris Beijerinck (Chlorophyceae) | Author: Czerpak R., Bajguz A., Piotrowska A., Polecka M. | Year: 2001 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Use of Lemna minor L. as a bioassay in allelopathy. | Author: Einhellig F.A., Leather G.R. and Hobbs L.L. | Year: 1985 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Qualitative and quantitative characterization of phenolic compounds from Lantana (Lantana camara) leaves. | Author: Jain R., Singh M. and Dezman D.J. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Effects of three phenolic compounds on Lemna gibba G3 | Author: Ramirez Toro G.I., Leather G.R. and Einhellig F.A. | Year: 1988 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: Palla J.C., Dion M. | Year: 1983 | Guideline: AFNOR T 9030 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 | Author: STERNALSKI R. | Year: 1992 | Guideline: Draft of norm ISO/CD 10712 (1990-10-10) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 | Author: STERNALSKI R. | Year: 1992 | Guideline: Draft of norm ISO/CD 10712 (1990-10-10) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Structure-toxicity assessment of metabolites of the aerobic bacterial transformation of substituted naphtalenes. | Author: Leblond J.D. et al. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells. | Author: Sheu C.W. et al. | Year: 1975 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: DIN 38412-8 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Models for estimating the non-specific toxicity of organic compounds in short-term bioassays. | Author: Gunatilleka A.D. and Poole C.F. | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Détermination de la toxicité aiguë à l'égard de la daphnie de diverses substances chimiques. | Author: D. Decros | Year: 1984 | Guideline: AFNOR T 90301 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Photobacterium phosphoreum Toxicity data index | Author: Kaiser K.L.E. and Palabrica V.S. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: A panel of bioluminescent biosensors for characterization of chemically-induced bacterial stress responses. | Author: Van Dyk T.K. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. | Author: Knie J. et al. | Year: 1983 | Guideline: Kuhn test | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Erste Ansätze zur ökologischen Bewertung von Pharmaka in Oberflächengewässern. | Author: Kalbfus W., Kopf W. | Year: 1998 | Guideline: DIN 38412-8 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Environmental hazard assessment of pharmaceuticals. | Author: Henschel K.P., Wenzel A., Dietrich M., Fliedner A. | Year: 1997 | Guideline: draft (Pauli 1996) | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Role of EDTA in a simple method for determining toxicity using a bacterial indicator organism. | Author: Botsford J.L. | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Evaluation of the OECD activated sludge respiration inhibition test. | Author: Klecka G.M. and Landi L.P. | Year: 1985 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Application of the Microtox system to assess the toxicity of pesticides and their hydrolysis metabolites. | Author: Somasundaram L. et al. | Year: 1990 | Guideline: ISO 11348-3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to soil macro-organisms except anthropods | Robust Study Summary -- Title: Effect of aromatic compounds humic acids and lignins on growth of the earthworm Eisenia foetida. | Author: Hartenstein R. | Year: 1982 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Action model of allelopathic compounds on seed germination. Allelochemicals Mycotoxins and Insect Pheromones and Allomones. | Author: Hsu F.H., Chiu C.Y., Chou C.H. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Plant damage caused by antiseptics 2 | Author: Fukushima and Masafumi | Year: 1998 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Effects of salicylic acid on tomato (Lycopersicon esculentum Mill.) productivity. | Author: Kalarani M.K., Thangaraj M., Sivakumar R. and Mallika V. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Salicylate de Methyle détermination de l'effet inhibiteur du développement de Pseudomonas putida selon le projet de norme ISO/CD 10712 du 10.10.1990 | Author: STERNALSKI R. | Year: 1992 | Guideline: Draft of norm ISO/CD 10712 (1990-10-10) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bio-distribution in rats of some salicylates with low gastric ulcerogenicity. | Author: Rainsford K.D. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Effects of salicylic acid on the development and root nodulation of soybean seedlings. | Author: Lian B. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The binding of salicylate to plasma protein from several animals species | Author: Kucera J.L., Bullock F.J. | Year: 1969 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Effects of salicylic acid on plant-water relationships | Author: Barkosky R.R., Einhellig F.A. | Year: 1993 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Salicylic acid metabolism in pregnant rats | Author: Emudianughe T.S. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Valuation of phytotoxic activity of naturally occurring|phenolic compounds | Author: Kobayashi Y. and Ito M. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: On the metabolism and toxicity of methyl salicylate. | Author: Davison C., Zimmerman E.F., Smith P.K. | Year: 1961 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Identification and phytotoxic activity of compounds produced during decomposition of corn and rye residues in soil | Author: Chou C.H., Patrick Z.A. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Salicylic acid-induced lipid peroxidation in rat liver microsomes | Author: Doi H., Masubuchi Y., Narimatsu S. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to soil microorganisms | Robust Study Summary -- Title: Significance and application of microbial toxicity tests in assessing ecotoxicological risks of contaminants in soil and sediment. | Author: Van Beelen P. and Doelman P. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats | Author: McMahon T.F., Diliberto J.J., Birnbaum L.S. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Biological effects monitoring | Robust Study Summary -- Title: The natural history of salicylic acid plant product and animal medicine. | Author: Pierpoint W.S. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Protein of acetylsalicylic acid and salicylic acid in porcine and human serum | Author: Lee S., Johnson D., Klein J., Eppler J. | Year: 1995 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Additional ecotoxicological information | Robust Study Summary -- Title: Developmental hazard assessment with FETAX : aerobic metabolites in bacterial transformation of naphtalene. | Author: Schultz T.W. and Dawson D.A. | Year: 1995 | Guideline: FETAX test on xenopus | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Serum salicylate levels in rats following the administration of salicylic acid and sodium salicylate suppositories. | Author: Crowell W.J., Puffer H.W. | Year: 1970 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Additional ecotoxicological information | Robust Study Summary -- Title: Identification of mechanisms of toxic action of phenols to Tetrahymena pyriformis from molecular descriptors. | Author: Schultz T.W. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Further observations on the disposition characteristics of salicylic acid in analbuminemic rats | Author: Hirate J. et al. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Additional ecotoxicological information | Robust Study Summary -- Title: Effects of salicylic acid and related compounds on photosynthetic parameters in young maize (Zea mays L.) plants. | Author: Janda T. et al. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: On the renal excretion of salicylate | Author: Dalgaard-Mikkelsen S. | Year: 1951 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Additional ecotoxicological information | Robust Study Summary -- Title: Feeding is inhibited by sublethal concentrations of toxicants and by heat stress in the nematode Caenorhabditis elegans : relationship to the cellular stress response. | Author: Jones D. and Candido E.P.M. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Salicylate metabolism in man | Author: Davison C. | Year: 1971 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Additional ecotoxicological information | Robust Study Summary -- Title: Quantitative structure-activity relationships for the toxicity to the Tadpole Rana japonica of selected phenols. | Author: Wang X. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Central nervous system salicylate | Author: Reed J.R., Palmisano P.A. | Year: 1975 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Eco-Tox | Additional ecotoxicological information | Robust Study Summary -- Title: Jasmonic acid signaling modulates ozone-induced hypersensitive cell death. | Author: Rao M.V. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Whole-body autoradiography of late pregnant mice after intravenous injection of 14C-labelled salicylic acid and acetylsalicylic acid. | Author: Tjalve H., Sjostrand S.E., Hansson E. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: SCCS OPINION ON salicylic acid (CAS 69-72-7) - Submission I | Author: U. Bernauer et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of Low-Dose Oral Modified Release Soluble and Intravenous Aspirin in Man and Effects on Platelet Function | Author: Bochner F. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Percutaneous absorption of salicylic acid after repeated (14-day) in vivo administration to normal acnegenic or aged human skin | Author: Davis D.A.P. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Relative bioavailability of salicylic acid following dermal application of a 30% salicylic acid skin peel preparation | Author: Fung W., Orak D., Re T.A., Haughey D.B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers | Author: Nagelschmitz J. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption of salicylic acid through the oral mucous membrane of hamster cheek pouch | Author: Tanaka M., Yanagibashi N., Fukuda H., Nagai T, | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys | Author: Wilson J.G., Scott W.J. and Ritters E.S. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Chapter 26 Salicylates In The Pharmacological Basis of Therapeutics 11th edition | Author: Goodman and Gilman | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats | Author: McMahon T.F., Diliberto J.J., Birnbaum L.S. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Kinetic analysis of the transport of salicylic acid a nonsteroidal anti-inflammatory drug across human placenta | Author: Shintaku K. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biochemical mechanisms of salicylate teratology in the rat. | Author: Koshakji R.P., Schulert A.R. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Transfer across the perfused human placenta of antipyrine sodium and leucine | Author: Schneider H., Panigel M., Dancis J. | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: SCCS OPINION ON salicylic acid (CAS 69-72-7) - Submission I | Author: U. Bernauer et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biochemical mechanisms of salicylate teratology in the rat. | Author: Koshakji R.P., Schulert A.R. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption of some organic components through the skin in man | Author: Feldmann R.J. & Maibach H.I. | Year: 1970 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The metabolism of C14 carboxyl salicylic acid in the dog and in man | Author: Alpen E.L., Mandel H.G., Rodwell V.W., Smith P.K. | Year: 1951 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Extent of cutaneous metabolism during percutaneous absorption of xenobiotics | Author: Bronaugh R.L., Stewart R.F., Storm J.E. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Relationship of pKa and acute skin irritation in humans | Author: Berner B. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: In vivo percutaneous absorption of chemicals: a multiple dose study in rhesus monkeys | Author: Bucks D.A.W. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: SCCS OPINION ON salicylic acid (CAS 69-72-7) - Submission I | Author: U. Bernauer et al. | Year: 2019 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Barrier function of intact and impaired skin: percutaneous penetration of caffeine and salicylic acid | Author: Rubio L. et al. | Year: 2011 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Influence of some plant extracts on the transdermal absorption and penetration of marker penetrants | Author: Muhammad F., Wiley J., Riviere J.E. | Year: 2017 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Comparison of Franz cells and microdialysis for assessing salicylic acid penetration through human skin | Author: Leveque N., Makki S., Hadgraft J., Humbert P. | Year: 2004 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application | Author: Singh P., Roberts M.S. | Year: 1994 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: The In vitro Percutaneous Absorption of Radiolabelled Salicylic Acid at a Single Concentration Through Human Skin | Author: Unilever | Year: 2016 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: In vitro permeability to salicylic acid of human rodent and shed snake skin | Author: Harada K. et al. | Year: 1993 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Role of partition coefficients in determining the percutaneous penetration of salicylic acid and formaldehyde under varying occlusion durations | Author: Hafeez F., Chiang A., Hui X., Maibach H. | Year: 2014 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: The In vitro Percutaneous Absorption of Radiolabelled Salicylic Acid at a Single Concentration Through Human Skin | Author: Unilever | Year: 2016 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous absorption of salicylic acid theophylline 24-dimethylamine diethyl hexyl phtgalic acid and p-aminobenzoic acid in the isolated perfused porcine skin flap compared to main in vivo | Author: Wester R.C. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Relative bioavailability of salicylic acid following dermal application of a 30% salicylic acid skin peel preparation | Author: Fung W., Orak D., Re T.A., Haughey D.B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Absorption of some organic components through the skin in man | Author: Feldmann R.J. & Maibach H.I. | Year: 1970 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous absorption of salicylic acid after repeated (14-day) in vivo administration to normal acnegenic or aged human skin | Author: Davis D.A.P. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute toxicity tests on 113 environmental chemicals | Author: Hasegawa R., Nakaji Y., Kurokawa Y., Tobe M. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The international validation study of the acute toxic class method (oral) | Author: Schlede E., Mischke U., Diener W., Kayser D. | Year: 1995 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology profiles on substances used in the FRAME cytotoxicology research project. | Author: Purchase I.F.H., Farrar D.G., Whitaker A.I. | Year: 1987 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Subacute inhalation toxicity of 109 industrial chemicals | Author: Gage J.C. | Year: 1970 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Hygienic standardization of methyl salicylate in workplace air | Author: Rumyantsev G.I. et al. | Year: 1992 | Guideline: 403 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate | Author: Cosmetic Ingredients Review Expert Panel (Fiume MZ) | Year: 2003 | Guideline: 403 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Untersuchungen zur akuten dermalen Toxitat an mannlichen und weiblichen Wistar-Ratten | Author: Bomhard E. | Year: 1989 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Acute toxicologic evaluation of salicylic acid | Author: Bomhard E. | Year: 1996 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Untersuchungen zur akuten dermalen Toxitat an mannlichen und weiblichen Wistar-Ratten | Author: Bomhard E. | Year: 1989 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: other routes | Robust Study Summary -- Title: Toxicité aiguë essai N° HF/D-0002 | Author: Blanchard J.C., Ghaye J. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Salicylic Acid- Pharmaceutical Grade CAS NB 69-72-7 Primary Skin Irritation Study in Rabbits (4 Hour semi-Occlusive Application) | Author: Arcelin G. | Year: 2008 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Assessment of cutaneous irritation of formaldehyde salicylic acid and sodium sulfate using transdermal laser doppler velocimetry. | Author: Blalock L.E., Montero-Riviere N.A. | Year: 1989 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Studies on eye irritation caused by chemicals in rabbits II. Structure-activity relationships and in vitro approach to primary eye irritation of salicylates in rabbits. | Author: Sugai S., Murata K., Kitagaki T., Tomita I. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Untitled. | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Salicylic Acid- Pharmaceutical Grade CAS NB 69-72-7 Primary Skin Irritation Study in Rabbits (4 Hour semi-Occlusive Application) | Author: Arcelin G. | Year: 2008 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (1) Overview of the validation study and Draize scores for the evaluation of the test | Author: Ohno Y. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bovine corneal opacity and permeability test: an in vitro assay of ocular irritancy | Author: Gautheron P., Dukic M., Alix D., Sin J.F. | Year: 1992 | Guideline: 437 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: The In vitro Percutaneous Absorption of Radiolabelled Salicylic Acid at a Single Concentration Through Human Skin | Author: Unilever | Year: 2016 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Strategies for identifying false positive responses in predictive skin sensitization tests | Author: Basketter D.A., Gerberick G.F., Kimber I. | Year: 1998 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Development and validation of an alternative dermal sensitization test : the mouse ear swelling test (MEST). | Author: Gad S.C. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Examination of the Local Lymph Node Assay for Use in Contact Sensitization Risk Assessment | Author: Gerberick G.F., House R.V., Fletcher E.R., Ryan C.A. | Year: 1992 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Evaluation of lymphocyte proliferation by immunohistochemistry in the lacal lymph node assay | Author: Boussiquet-Leroux C., Durand-Cavagna G., Herlin K., Holder D. | Year: 1992 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Untitled. | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: QSAR Study of Skin Sensitization using Local lymph Node Assay Data | Author: Fedorowicz A., Zheng L., Singh H., Demchuk E. | Year: 2004 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation. | Author: Basketter D.A. et al. | Year: 1999 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Phenotypic analysis of lymphocyte subpopulations in lymph nodes draining the ear following exposure to contact allergens and irritants. | Author: Sikorsky E.E. et al. | Year: 1996 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits | Author: Webb W.K., Hansen W.H. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. | Author: Abbott D.D., Harrisson J.W.E. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats | Author: FDA | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate | Author: Cosmetic Ingredients Review Expert Panel (Fiume MZ) | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: untitled | Author: Anonymous | Year: 1971 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Salicylates and other hydroxybenzoates: Effect upon osseous tissue of young rats. | Author: Harrisson J.W.E., Abbott D.D., Packman E.W. | Year: 1963 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Salicylates and other hydroxybenzoates: Effect upon osseous tissue of young rats | Author: Harrisson J.W.E., Abbott D.D., Packman E.W. | Year: 1963 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subacute inhalation toxicity of 109 industrial chemicals | Author: Gage J.C. | Year: 1970 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits | Author: Webb W.K., Hansen W.H. | Year: 1963 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity test data existing chemical substances based on the toxicity investigation system of the industrial safety and health law supplement 2. | Author: Ministry of Labour Japan: Chemical Substance Investigation Division Industrial Safety & Health Department Labour Standard Bureau | Year: 2000 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Cell mutation assay at the thymidine kinase locus in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 | Author: Wollny H-E | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Cell mutation assay at the thymidine kinase locus in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 | Author: Wollny H-E | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: untitled | Author: Anonymous | Year: 1971 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The action of transition metals on the genotoxicity of simple phenols phenolic acids and cinnamic acids. | Author: Stich H.F., Rosin M.P., Wu C.H., Powrie W.D. | Year: 1981 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Absence of mutagenic activity of benorylate paracetamol and acetylsalicylic acid in the Salmonella/mammalian cell cultures. | Author: Jasiewicz M.L., Richardson J.C. | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mechanism of the lethal and mutagenic effects of phenoxyacetic acids in Saccharomyces cerevisiae. | Author: Zetterberg G. | Year: 1979 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Salicylic Acid- Pharmaceutical Grade CAS NB 69-72-7 Primary Skin Irritation Study in Rabbits (4 Hour semi-Occlusive Application) | Author: Arcelin G. | Year: 2008 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Survey of chemicals for mutagenic action on E. coli. | Author: Demerec M., Bertani G., Flint J. | Year: 1951 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Untitled | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chromosal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens | Author: Ishidate M., Jr Sofuni T., Yoshikawa K. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of 80 chemicals in Escherichia coli tester strains IC203 deficient in OxyR and its oxyR+ parent WP2 uvrA/pKM101: detection of 31 oxidative mutagens | Author: Martinez A., Urios A., Blanco M. | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. | Author: McCann J., Choi E., Yamasaki E., Ames B. | Year: 1975 | Guideline: 471 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells | Author: Sheu C.W. et al. | Year: 1975 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Untitled. | Author: Anonymous | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. | Author: Ishidate M., Harnois M.C., Sofuni T. | Year: 1988 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Euglena gracilis as an eukaryotic test organism for detecting mutagens and antimutagens | Author: Foltinova P.,Grones J. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Pharmacological studies on the mutagenicity : I. Analgesics and antiinflammatory drugs and their derivatives. | Author: Tamura T., Fujii A., Kuboyama N. | Year: 1980 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice. | Author: Giri A.K., Adhikari N., Khan K.A. | Year: 1996 | Guideline: EPA OPPTS 870.5915 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice. | Author: Giri A.K., Adhikari N., Khan K.A. | Year: 1996 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic and subacute toxicology and pathology of methyl salicylate in dogs rats and rabbits | Author: Webb W.K., Hansen W.H. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. | Author: Stoner G.D. et al. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Screening tests of various chemical substances as carcinogenic hazards. | Author: Umeda M. | Year: 1957 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Cocarcinogenic action of acetylsalicylic acid on gastric tumors induced by N-nitroso-N-methylnitro-guanidine in rats | Author: Chang T-H et al. | Year: 1983 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The effects of long-term administration of acetylsalicylic acid and sodium saccharin on the rat kidney. | Author: Johansson S.L. et al. | Year: 1986 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Effect on methyl salicylate on rat reproduction | Author: Collins T.F.X., Hansen W.H., Keeler H.V. | Year: 1971 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Evaluation of safety for food additives: An illustration involving the influence of methyl salicylate on rat reproduction | Author: Gross M.A., Fitzhugh O.G. | Year: 1970 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl salicylate: studies of osseous changes in the rat reproduction in the rat and mouse and liver and kidney effects in the dog. | Author: Abbott D.D., Harrisson J.W.E. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. | Author: Reel J.R. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies | Author: Chapin R.E., Sloane R.A. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice | Author: Morrissey R.E., Lamb IV JC Morris RW et al | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl Salicylate: Swiss CD-1 mice at 0.0 25 50 and 100 mg/kg by gavage | Author: Lamb IV J.C. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. | Author: Gulati D.K., Choudhury H., Chambers R., Sabharwal P.S. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Reproduction studies on sodium meclofenamate in comparison to acetylsalicylic acid and phenylbutazone. | Author: Schardein J.L., Blatz A.T., Woosley E.T., Kaump D.H. | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Teratogenic and reproductive effects of ethanol in Long-Evans rats. | Author: Mankes R.F. et al. | Year: 1982 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Evaluation of the teratogenic potential of fresh-brewed coffee and caffiene in the rat. | Author: Palm P.E. et al. | Year: 1978 | Guideline: 415 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats | Author: FDA | Year: 1966 | Guideline: EU B.34 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Safety Assessment of Salicylic Acid Butyloctyl- Calcium- C12-15 Alkyl Salicylate Capryloyl Salicylic Acid Hexyldodecyl- Isocetyl- Isodecyl- Magnesium- MEA- Ethylhexyl- Potassium- Methyl- Myristyl- Sodium- TEA- and Tridecyl Salicylate | Author: Cosmetic Ingredients Review Expert Panel (Fiume MZ) | Year: 2003 | Guideline: EU B.34 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Comparison of developmental toxicology of Aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development | Author: Cappon G.D. et al. | Year: 2003 | Guideline: ICH Topic S 5(R2) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: untitled | Author: Anonymous | Year: 1971 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms. | Author: Gupta U., Cook J.C., Tassinari M.S., Hurtt M.E. | Year: 2003 | Guideline: ICH Topic S 5(R2) | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Studies on the teratogenicity of food additives (3): Teratogenic effect of dietary salicylic acid in rats | Author: Tanaka S. et al. | Year: 1973 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Reproduction studies on sodium meclofenamate in comparison to acetylsalicylic acid and phenylbutazone. | Author: Schardein J.L., Blatz A.T., Woosley E.T., Kaump D.H. | Year: 1969 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Evaluation of the teratogenic potential of chemicals in the rat. | Author: Fritz H., Giese K. | Year: 1990 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Comparative teratogenicity study of diflunisal (MK-647) and aspirin in the rat | Author: Nakatsuka T., Fujii T. | Year: 1979 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Relationship between Cyclooxygenase 1 and 2 selective inhibitors and fetal development when administred to rats and rabbits during the sensitive periods for heart development and midline closure | Author: Cappon G.D., Cook J.C., Hurtt M.E. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Cell mutation assay at the thymidine kinase locus in mouse lymphoma L5178Y cells with salicylic acid pharmaceutical grade-CAS# 69-72-7 | Author: Wollny H-E | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenic and reproductive effects of ethanol in Long-Evans rats. | Author: Mankes R.F. et al. | Year: 1982 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Biochemical mechanisms of salicylate teratology in the rat. | Author: Koshakji R.P., Schulert A.R. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A comparison of forced oral administration and feeding method on the teratogenic effect and fetal distribution of salicylic acid in rats. | Author: Tanaka S. | Year: 1974 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Maternal reproductive effects of oral salicylic acid in Sprague-Dawley rats. | Author: Davis D.P. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chemical exposure of embryos during the preimplantation stages of pregnancy: Mortality rate and intrauterine development | Author: Fabro S., McLachlan J.A., Dames N.M. | Year: 1984 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Postnatal evolution of supernumerary ribs in rats after single administration of sodium salicylate. | Author: Foulon O. et al. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Induction of supernumerary ribs with sodium salicylate. | Author: Foulon O. et al. | Year: 1999 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity interactions of salicylic acid and radiofrequency radiation or 2-methoxyethanol in rats. | Author: Nelson B.K., Snyder D.L., Shaw P.B. | Year: 1999 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Effect of dietary sodium selenite supplementation on salicylate-induced embryo-and fetotoxicity in the rat. | Author: Bergman K. et al. | Year: 1990 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenic mechanisms of medical drugs. | Author: van Gelder M.M. et al. | Year: 2010 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Species differences in pharmacokinetics and drug teratogenesis. | Author: Nau H. | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Salicylate Reproductive Toxicity Review | Author: Bingham P. | Year: 2010 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Validation of an in vivo developmental toxicity screen in the mouse. | Author: Seidenberg J.M., Anderson D.G., Becker R.A. | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: The effect of acute maternal toxicity on fetal development in the mouse. | Author: Kavlock R.J., Chernoff N., Rogers E.H. | Year: 1985 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Postnatal development of young rats following the treatment of the dams with sodium salicylate during late periods of pregnancy. | Author: Fritz H., Suter H.P. | Year: 1985 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A teratology test system which utilizes postnatal growth and viability in the mouse. | Author: Chernoff N., Kavlock R.J. | Year: 1983 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: An in vivo teratology screen utilizing pregnant mice. | Author: Chernoff N., Kavlock R.J. | Year: 1982 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Mechanisms regulating toxicant deposition to the embryo during early pregnancy: an interspecies comparison | Author: Carney E.W., Scialli A.R., watson R.E., deSesso J.M. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: disregarded due to major methodological deficiencies. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Protection by free oxygen radical scavenging enzymes against salicylate-induced embryonic malformations in vitro. | Author: Karabulut A.K., Ulger H., Pratten M.K. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: disregarded due to major methodological deficiencies. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Teratogenicity of salicylate and its metabolites (24-dihydroxybenzoic acid and 25-dihydroxybenzoic acid) studied in the rat embryo culture method | Author: Akita M., Yokoyama A., Kontani H. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: disregarded due to major methodological deficiencies. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: In vitro developmental toxicity of acetylsalicylic acid and its major metabolites on cultured fetal mouse palates | Author: Kosazuma T., Chou M.J., Kawauchi S., Shiota K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: disregarded due to major methodological deficiencies. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Preliminary studies on the in vitro and in vivo effect of salicylate on sperm motility | Author: Porat-Soldin O., Soldin S.J. | Year: 1992 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Embryonal disposition of salicylate: In vivo-in vitro comparisons | Author: Daston G.P. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: disregarded due to major methodological deficiencies. | - |
| Toxicological | Toxicity to reproduction: other studies | Robust Study Summary -- Title: Embryotoxic effects of salicylates: Role of biotransformation. | Author: Greenaway J.C., Bark D.H., Juchau M.R. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: disregarded due to major methodological deficiencies. | - |