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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC handbook of chemistry and physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of chemistry and physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC handbook of chemistry and physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Weast R.C. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC handbook of chemistry and physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Verschueren K. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals | Author: Mackay D. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Horvath A.L. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals | Author: Mackay D. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation of log Kow for dichloromethane (CAS 75â€09â€2 ) using EPISUITE 4.0 | Author: Zvinavashe E. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Estimation of log Kow for dichloromethane (CAS 75â€09â€2 ) using EPISUITE 4.0 | Author: Zvinavashe E. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals | Author: Mackay D. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: No information | Author: No author provided | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Excess molar volumes and excess viscosities of 2-propanol + methylacetate + dichloromethane at 298.15 K | Author: Acevedo I.L. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Chlorohydrocarbon Solvents | Author: McGovern E.W. | Year: 1943 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Schwer entzuendbare Gase und Daempfe - Erweiterung der europaeischen Norm EN 1839 | Author: Brandes W., Milde J., Schroeder V. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: No information | Author: Nabert K., Schön G. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: No information | Author: Steen H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Schwer entzuendbare Gase und Daempfe - Erweiterung der europaeischen Norm EN 1839 | Author: Brandes W., Milde J., Schroeder V. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: No information | Author: Sax N.I., Lewis R.J. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kennzahlen brennbarer Gase und Dämpfe | Author: Nabert K., Schön G. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Explosionsgefahren beim Umgang mit Chlorkohlenwasserstoffen und deren Gemischen mit brennbaren Flüssigkeiten | Author: Steen H., Redeker T. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Explosionsgefahren beim Umgang mit Chlorkohlenwasserstoffen und deren Gemischen mit brennbaren Flüssigkeiten | Author: Steen H., Redeker T. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: Lewis R.J. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Author: Nabert K., Schön G. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: Steen H., Redeker T. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: Steen H., Redeker T. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Investigation of a possibility to reduce the use of rabbits in skin irritation tests; experiments with dichloromethane trichloroethylene tetrachloroethylene and 111-trichloroethane | Author: Beek van L. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Investigation of a possibility to reduce the use of rabbits in skin irritation tests; experiments with dichloromethane trichloroethylene tetrachloroethylene and 111-trichloroethane | Author: Beek van L. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Ophthalmic toxicology of dichloromethane | Author: Ballantyne B. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Assessment of contact hypersensitivity to Dichloromethane in the mouse (Local Lymph Node Assay) | Author: Huygevoort AHBM | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Assessment of contact hypersensitivity to Dichloromethane in the mouse (Local Lymph Node Assay) | Author: Huygevoort AHBM | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of cosmetic ingredients licensed by the European Communities | Author: Gocke E. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: The MAK Collection for Occupational Health and Safety - Dichloromethane | Author: MAK | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Induction of chromosome damage by methylene chloride in CHO cells | Author: Thilagar A.K., Kumaroo P.V. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Dichloromethane | Author: IARC | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity testing of dichloroethane in short-term mammalian test systems | Author: Jongen W.M.F. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity of cosmetic ingredients licensed by the European Communities | Author: Gocke E. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The MAK Collection for Occupational Health and Safety - Dichloromethane | Author: MAK | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Analysis of DNA adducts formed in vivo in rats and mice from 12-Dibromoethane 12-Dichloroethane Dibromomethane and Dichloromethane using HPLC/Accelerator Mass Spectrometry and relevance to risk estimates | Author: Watanabe K. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Methylene chloride (dichloromethane): An evaluation in the mouse micronucleus test | Author: Sheldon T. et al. | Year: 1986 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Methylene chloride (dichloromethane): An evaluation in the mouse micronucleus test | Author: Sheldon T. et al. | Year: 1986 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Inactivity of methylene chloride in the mouse bone marrow micronucleus assay | Author: Sheldon T. et al. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Dichloromethane | Author: IARC | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Methylene Chloride (Second Edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute oral toxicity study with dichloromethane in rats. | Author: Janssen P.J.M., Pot T.E. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute oral toxicity study with dichloromethane in rats. | Author: Janssen P.J.M., Pot T.E. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Methylene Chloride (Second Edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: The toxicity and narcotic action of mono-chloromono- bromo-methane with special reference to inorganic and volatile bromide in blood urine and brain. | Author: Svirbely J.L. et al. | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Acute dermal toxicity study with dichloromethane in rats | Author: Janssen P.J.M., Pot T.E. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Acute dermal toxicity study with dichloromethane in rats | Author: Janssen P.J.M., Pot T.E. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Methylene Chloride (Second Edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice | Author: Evans M.V., Caldwell J.C. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Induction of hepatic CYP2E1 by a subtoxic dose of Acetaminophen in rats: increase in Dichloromethane metabolism and carboxyhemoglobin elevation | Author: Kim S.N. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane | Author: Kim S.N. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Recommendation from the Scientific Committee on Occupational Expsoure Limits for methylene chloride (dichloromethane) | Author: SCOEL | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations | Author: David R.M. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicological Review of dichloromethane (methylene chloride) | Author: USEPA | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Physiologically Based Pharmacokinetics and the Risk Assessment Process for Methylene Chloride | Author: Andersen M.E. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dichloromethane | Author: IARC | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Revised assessment of cancer risk to dichloromethane: Part I Bayesian PBPK and dose-response modeling in mice | Author: Marino D.J. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The MAK Collection for Occupational Health and Safety - Dichloromethane | Author: MAK | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling | Author: Rodriguez C. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Re-evaluation of some organic chemicals hydrazine and hydrogen peroxide | Author: IARC | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Letter to the Editor | Author: Anders M.W. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A two-year drinking-water study of dichloromethane in rodents I. Rats | Author: Serota D.G. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A two-year drinking-water study of dichloromethane in rodents II. Mice | Author: Serota D.G. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methylene Chloride (Second Edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Continuous animal exposure to low levels of dichloromethane | Author: Haun C.C. et al. | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Hepatotoxicity of dichloromethane (methylene chloride) with continuous exposure at a low dose level | Author: Weinstein R.S. et al. | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicological profile for methylene chloride | Author: ATSDR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signalling in dichloromethane carcinogenicity in mouse lung and liver | Author: Andersen M.E. et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats | Author: Nitschke K.D. et al. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Use of Short-term Transcriptional Profiles to Assess the Long-term Cancer-Related Safety of Environmental and Industrial Chemicals | Author: Thomas R.S. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation carcinogenicity of dichloromethane in rats and mice | Author: Aiso S. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methylene Chloride (Second Edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Report on subacute toxicological studies with dichloromethane in rats and dogs by inhalation | Author: Leuschner F. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies) | Author: NTP | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Neurotoxicologic evaluation of rats after 13 weeks of inhalation exposure to dichloromethane or carbon monoxide. | Author: Mattsson J.L. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicology of dichloromethane (methylene chloride). I. Studies on effects of daily inhalation. | Author: Heppel L.A. et al. | Year: 1944 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Continuous animal exposure to low levels of dichloromethane | Author: Haun C.C. et al. | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Absence of dichloromethane teratogenicity with inhalation exposure in rats | Author: Hardin B.D., Manson J.M. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Behavioral toxicity in the offspring of rats following maternal exposure to dichloromethane | Author: Bornschein R.L. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methylene Chloride (2nd edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: The effect of maternally inhaled trichloroethylene perchloroethylene methylene chloroform methylene chloride on embryonal and fetal development in mice and rats | Author: Dow Chemical Company | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: The effect of maternally inhaled trichloroethylene perchloroethylene methylene chloroform methylene chloride on embryonal and fetal development in mice and rats | Author: Dow Chemical Company | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: The effects of maternally inhaled trichloroethylene perchloroethylene methyl chloroform and methylene chloride on embryonal and fetal development in rats and mice | Author: Schwetz B.A. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methylene Chloride: Two generation inhalation reproduction study in fischer 344 rats | Author: Dow Chemical Company | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Methylene Chloride: Two generation inhalation reproduction study in fischer 344 rats | Author: Dow Chemical Company | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methylene chloride: two-generation inhalation reproductive study in rats | Author: Nitschke K.D. et al. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Recommendation of the Scientific Committee on Occupational Exposure Limits for Methylene Chloride (Dichloromethane | Author: SCOEL | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicological profile for methylene chloride | Author: ATSDR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Methylene Chloride: Effects on Estrus Cycling and Serum Prolactin in Sprague-Dawley Rats | Author: Dow Chemical Company | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Methylene Chloride: Effects on Estrus Cycling and Serum Prolactin in Sprague-Dawley Rats | Author: Dow Chemical Company | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Dichloromethane | Author: IARC | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Inhalation carcinogenicity of dichloromethane in rats and mice | Author: Aiso S. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Summary of inhalation carcinogenicity study of dichloromethane in BDF1 mice | Author: JBRC | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: A two-year drinking-water study of dichloromethane in rodents I. Rats | Author: Serota D.G. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The MAK Collection for Occupational Health and Safety - Dichloromethane | Author: MAK | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies) | Author: NTP | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Inhalation toxicology and carcinogenesis studies of methylene chloride (dichloromethane) in F344/N rats and B6C3F1 mice | Author: Mennear J.H. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Methylene Chloride (Second Edition) | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicological profile for methylene chloride | Author: ATSDR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Inhalation carcinogenicity of dichloromethane in rats and mice | Author: Aiso S. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Summary of inhalation carcinogenicity study of dichloromethane in F344 rats | Author: JRBC | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: A two-year drinking-water study of dichloromethane in rodents II. Mice | Author: Serota D.G. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats | Author: Nitschke K.D. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies) | Author: NTP | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Inhalation toxicology and carcinogenesis studies of methylene chloride (dichloromethane) in F344/N rats and B6C3F1 mice. | Author: Mennear J.H. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas) | Author: Geiger D.L. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity of Cadmium Copper Zinc Ammonia 33'-Dichlorobenzidine 26-Dichloro-4-Nitroaniline Methylene Chloride and 246- Trichlorophenol to Juvenile Grass Shrimp and Kilifish | Author: Burton D.T., Fisher D.J. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity of Priority Pollutants to Bluegill (Lepomis macrochirus) | Author: Buccafusco R.J. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Methylene Chloride to Life Stages of the Fathead Minnow | Author: Dill D.C. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of perchloroethane and methylene chloride to fathead minnows | Author: Alexander H.C., McCarty W.M., Bartlett E.A. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Toxicity of methylene chloride to daphnids | Author: McCarty W.M. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Toxicity of methylene chloride to daphnids | Author: McCarty W.M. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute Toxicity of Cadmium Copper Zinc Ammonia 33'-Dichlorobenzidine 26-Dichloro-4-Nitroaniline Methylene Chloride and 246- Trichlorophenol to Juvenile Grass Shrimp and Kilifish | Author: Burton D.T., Fisher D.J. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Toxicity assessment of common xenobiotic compounds on municipal activated sludge: comparison between respirometry and Microtoxs | Author: Ricco G. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Methylene Chloride to Life Stages of the Fathead Minnow | Author: Dill D.C. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: The toxicity of methylene chloride to the embryo larval and juvenile stages of teh fathead minnow pimephales promelas rafinesque | Author: Dill D.C. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: QSAR case study: Prediction of long-term NOEC for Daphnia magna for Dichloromethane | Author: OECD | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: QSAR case study: Prediction of long-term NOEC for Daphnia magna for Dichloromethane | Author: OECD | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Health assessment document for dichloromethane (methylene chloride) | Author: Bayard S.P. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Handbook of Chemical Property Estimation Methods | Author: Lyman W.J. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: An evaluation of using partition coefficients and water solubility to estimate bioconcentration factors for organic chemicals in fish | Author: Veith G.D. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bio-accumulation study on dichloromethane | Author: Chemicals Inspection and Testing Institute Japan | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to birds | Robust Study Summary -- Title: Effect of trichloroethylene tetrachloroethylene and dichloromethane on enzymatic activities in soil. | Author: Kanazawa S., Filip Z. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Evaporation rates of methyl chloride chloroform 111-trichloroethane trichloroethylene tetrachloroethylene and other chlorinated compounds in dilute aqueous solutions | Author: Dilling W.L. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Product distribution and reaction pathways for methylene chloride hydrolysis and oxidation under hydrothermal conditions | Author: Marrone P.A. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: Fate of selected volatile organic substances in aqueous environment | Author: Chodola G.R. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The kinetics of the hydrolysis of metylene chloride | Author: Fells I., Moelwyn-Hughes E.A. | Year: 1958 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: Review of the environmental fate of selected chemicals | Author: Radding S.B. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Effects of Bacterial Host and Dichloromethane Dehalogenase on the competitiveness of Methylotrophic Bacteria Growing with Dichloromethane | Author: Gisi D. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Molecular characterization of dichloromethane-degrading Hyphomicrobium strains using 16 S rDNA and DCM dehalogenase gene sequences | Author: Nikolausz M. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Isolation of a Xanthobacter sp. degrading dichloromethane and characterization of the gene involved in the degradation | Author: Emanuelsson MAE et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Metabolism of dichloromethane by the strict anaerobe dehalobacterium formicoaceticum | Author: Magli A., Messmer M., Leisinger T. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A novel dichloromethane-degrading Lysinibacillus sphaericus strain wh22 and its degrative plasmid | Author: Wu S.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A mathematical model of biodegradability screening tests as an aid to interpretation of observed results | Author: Painter H.A., King E.F. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Dichloromethane utilized by an anaerobic mixed culture: acetogenesis and methanogenesis | Author: Stromeyer S.A. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Bacterial Degradation of Dichloromethane | Author: Brunner W., Staub D., Leisinger T. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biological treatability of specific organic compounds found in chemical industry wastewaters | Author: Stover E.L., Kincannon D.F. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Specialized bacterial strains for the removal of dichloromethane from industrial waste | Author: Galli R., Leisinger T. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Dichloromethane dehalogenase with improved catalytic activity isolated from a fast-growing dichloromehtane-utilizing bacterium | Author: Scholtz R. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The biodegradation of methylene chloride in soils | Author: Davis J.W., Madsen S.S. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methylene Chloride - Second Edition | Author: WHO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Basic mirobial degradation rates and chemical byproducts of selected organic compounds | Author: Davis E.M. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Dehalogenation of Dichloromethane by Cell Extracts of Hyphomicrobium DM2 | Author: Stucki G. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Fate and effects of methylene chloride in activated sludge | Author: Klecka G.M. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Microbes enzymes and genes involved in dichloromethane utilization | Author: Leisinger T. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Fate and effects of methylene chloride in activated sludge | Author: Klecka G.M. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Fate and effects of methylene chloride in activated sludge | Author: Klecka G.M. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Fate and Effects of Methylene chloride in Activated sludge | Author: Klecka G.M. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradability of dichloromethane (CAS 75-09-2) in the closed bottle test (OECD TG 301D) | Author: Ginkel van C.G. | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradability of dichloromethane (CAS 75-09-2) in the closed bottle test (OECD TG 301D) | Author: Ginkel van C.G. | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Genetic Adaptation of Bacteria to Halogenated Aliphatic Compounds | Author: Janssen D.B., Ploeg van der J.R., Pries F. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Protein engineering studies of dichloromethane dehalogenase/glutathione S-transferase from Methylophilus sp strain DM11 Ser 12 but not Tyr6 is required for enzym activity | Author: Vuilleumier S., Leisinger T. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of dichloromethane in an estuarine environment | Author: Krausova V.I., Robb F.T., Gonzalez J.M. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of dichloromethane and its utilization as a growth substrate under methanogenic conditions | Author: Freedman D.L., Gossett J.M. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Dichloromethane as the sole carbon source for an acetogenic mixed culture and isolation of a fermentative dichloromethane-degrading bacterium | Author: Braus-Stromeyer S.A. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Dichloromethane | Author: OECD SIDS | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Health assessment document for dichloromethane (methylene chloride). Final report | Author: Bayard S.P. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Assessment of ready biodegradability of dichloromethane using weight of evidence approach | Author: Meussen B., Ginkel van C.G. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Assessment of ready biodegradability of dichloromethane using weight of evidence approach | Author: Meussen B., Ginkel van C.G. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Introductory study of the biodegradation of the chlorinated methane ethane and ethene compounds. Progress Report | Author: Wood P.R. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Microbial removal of halogenated methanes ethanes and ethylenes in an aerobic soil exposed to methane | Author: Henson J.M. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: The biodegradation of methylene chloride in soils | Author: Davis J.W., Madsen S.S. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial removal of halogenated methanes ethanes and ethylenes in an aerobic soil exposed to methane | Author: Henson J.M. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |