You are here: Home> Turkey>TR-REACH>CAS 78-93-3> CAS 78-93-3 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (89th Ed) | Author: Lide D.R. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: NIOSH Pocket Guide to Chemical Hazards | Author: National Institute for Occupational Safety and Health | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: NIOSH Pocket Guide to Chemical Hazards | Author: National Institute for Occupational Safety and Health | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of n-Octanol/Water Partition Coefficient of Methylethyl Ketone | Author: Jacobs R.L. et al. | Year: 1998 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of n-Octanol/Water Partition Coefficient of Methylethyl Ketone | Author: Jacobs R.L. et al. | Year: 1998 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide D.R. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methylethyl Ketone: Closed Bottle Test | Author: Schaefer et al. | Year: 1998 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Methylethyl Ketone: Closed Bottle Test | Author: Schaefer et al. | Year: 1998 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Methylethyl Ketone: A 96-Hour Static Acute Toxicity Test with the Fathead Minnow (Pimephales promelas) | Author: Drottar K.R. et al. | Year: 1998 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Methylethyl Ketone: A 96-Hour Static Acute Toxicity Test with the Fathead Minnow (Pimephales promelas) | Author: Drottar K.R. et al. | Year: 1998 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizität mit den Goldenorfentest | Author: Juhnke I. and Lüdemann D. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Methylethyl Ketone: A 48-Hour Static-Acute Immobilisation Test with the Cladoceran (Daphnia magna) | Author: Drottar K.R. et al. | Year: 1998 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Methylethyl Ketone: A 48-Hour Static-Acute Immobilisation Test with the Cladoceran (Daphnia magna) | Author: Drottar K.R. et al. | Year: 1998 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickelt standardisierten Testverfahren | Author: Bringmann G. and Kühn R. | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Methylethyl Ketone: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum) | Author: Drottar K.R. et al. | Year: 1998 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Methylethyl Ketone: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum) | Author: Drottar K.R. et al. | Year: 1998 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Comparison of the Toxicity Thresholds of Water Pollutants to Bacteria, Algae, and Protozoa in the Cell Multiplication Inhibition Test | Author: Bringmann G. and Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefhrdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G. and Kühn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G. and Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G. and Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparison of the Toxicity Thresholds of Water Pollutants to Bacteria, Algae, and Protozoa in the Cell Multiplication Inhibition Test | Author: Bringmann G. and Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G. and Kühn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. I. Bakterienfressende Flagellaten (Modellorganismus: Entosiphon sulcatum Stein) | Author: Bringmann G. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. II. Bakterienfressende Ciliaten | Author: Bringmann G. and Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. III. Saprozoische Flagellaten | Author: Bringmann G., Kühn R. and Winter A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance. | Author: DiVincenzo G.D., Kaplan C.J. and Dedinas J. | Year: 1976 | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of 2-butanol and its metabolites in the rat | Author: Dietz F.K. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price J.B. | Year: 1986 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 78-92-2 | EC 201-158-5 | butan-2-ol) |
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| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price J.B. | Year: 1986 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 78-92-2 | EC 201-158-5 | butan-2-ol) |
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| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Range-Finding Toxicity Data: List VI | Author: Smyth H. et al. | Year: 1962 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price J.B. | Year: 1986 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 78-92-2 | EC 201-158-5 | butan-2-ol) |
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| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price J.B. | Year: 1986 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 78-92-2 | EC 201-158-5 | butan-2-ol) |
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| Toxicological | Eye irritation | Robust Study Summary -- Title: Study of Intra- and Interlaboratory Variability in the Results of Rabbit Eye and Skin Irritation Tests | Author: Weil C.S. et al. | Year: 1971 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Eye Irritation: Reference chemicals data bank (second edition) | Author: ECETOC | Year: 1998 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: METHYL ETHYL KETONE: SKIN SENSITISATION STUDY IN THE GUINEA PIG (BUEHLER METHOD) | Author: Denton S.M. | Year: 1996 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: METHYL ETHYL KETONE: SKIN SENSITISATION STUDY IN THE GUINEA PIG (BUEHLER METHOD) | Author: Denton S.M. | Year: 1996 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 90-days vapour inhalation toxicity study of methyl ethyl ketone. | Author: Cavender F.E. et al. | Year: 1983 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Isopropanol 13-Week Vapor Inhalation Study in Rats and Mice with Neurotoxicity Evaluation in Rats | Author: Burleigh-Flayer H.D. et al. | Year: 1994 | Guideline: 413 | Adequacy: supporting study. Read-Across (CAS 67-63-0 | propan-2-ol) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston R.A.J. | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston R.A.J. | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston R.A.J. | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston R.A.J. | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Toxicological Review of Methyl Ethyl Ketone (CAS n. 78-93-3) | Author: US EPA | Year: 2003 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS butan-2-ol | EC 201-158-5 | 2-butanol / 78-92-2) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats. | Author: Nemec M.D. et al. | Year: 2004 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats | Author: Saillenfait et al. | Year: 2006 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of inhaled methyl ethyl ketone in Swiss mice | Author: Schwetz B. | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice. | Author: Tyl R.W. et al. | Year: 1987 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Lack of Selective Developmental Toxicity of Three Butanol Isomers Administered by Inhalation to Rats | Author: Nelson | Year: 1989 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 78-92-2 | EC 201-158-5 | butan-2-ol) |
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