You are here: Home> South Korea>K-REACH>CAS 88-12-0> CAS 88-12-0 | Data Package > 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS-Substance Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Technical Data Sheet, N-Vinyl-2-pyrrolidone | Author: BASF | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Handbook of Environmental Data on Organic Chemicals, 4th Edition | Author: Verschueren Karel | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics, 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Estimation of Melting Point for 2-Pyrrolidinone, 1-ethenyl- (CASRN: 88-12-0) using USEPA MpBpWIN v1.43 (June 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Estimation of Melting Point for 2-Pyrrolidinone, 1-ethenyl- (CASRN: 88-12-0) using USEPA MpBpWIN v1.43 (June 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics, 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Estimation of Boiling Point for 2-Pyrrolidinone, 1-ethenyl- (CASRN: 88-12-0) using USEPA MpBpWIN v1.43 (June 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Estimation of Boiling Point for 2-Pyrrolidinone, 1-ethenyl- (CASRN: 88-12-0) using USEPA MpBpWIN v1.43 (June 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Knovel Critical Tables | Author: Knovel | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010. | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Howard, Philip H. and Meylan, William M., Handbook of Physical Properties of Organic Chemicals | Author: Japan CHRIP Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: N-VINYL-2-PYRROLIDINONE | Author: SRC | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Sangster Research Laboratories LOGKOW© , a databank of evaluated octinol-water partition coefficients (Log P) | Author: Sangster Research Laboratories | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Hansch, C. A. Leo and D. Hoekman, Exploring QSAR-Hydrophobic, Electronic and Steric Constants, American Chemical Society | Author: Japan CHRIP Database | Year: 2010 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Hansch,C.,A.Leo and D.Hoekman(1995), Exploring QSAR-Hydrophobic, Electronic and Steric Constants,American Chemical Society | Author: SRC | Year: 2010 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Philip H. Howard, William M. Meylan, Handbook of Physical Properties of Organic Chemicals, Handbook of Physical Properties of Organic Chemicals | Author: Japan CHRIP Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Philip H. Howard, William M. Meylan, Handbook of Physical Properties of Organic Chemicals, Handbook of Physical Properties of Organic Chemicals | Author: SRC | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of Melting Point for 2-Pyrrolidinone, 1-ethenyl-(CASRN: 88-12-0) using USEPA WSKOWWIN v1.41 (June 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of Melting Point for 2-Pyrrolidinone, 1-ethenyl-(CASRN: 88-12-0) using USEPA WSKOWWIN v1.41 (June 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: N-Vinyl-2-Pyrrolidone Technical Data Sheet, Specifications | Author: BASF | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: O'Neil, M.J. (ed).The Merck Index - An Encyclopedia of Chemicals, Drugs and Biologicals, 13th Edition (2001) | Author: HSDB | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Technical Data Sheet, N-Vinyl-2-pyrrolidone | Author: BASF | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: 1-Vinyl-2-Pyrrolidone, International Chemical Safey Cards (ICSC), #1478 | Author: ILO | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Waiver | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Calculation of pKa value (dissociation constant) for N-Vinyl-2-pyrrolidone using SPARC Online v4.5 | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Right to refer to study -- Title: Calculation of pKa value (dissociation constant) for N-Vinyl-2-pyrrolidone using SPARC Online v4.5 | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: No information | Author: Atovmyan E.G. and Fedotova T.N. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: No information | Author: George John, Sastry and Nandhibatla V. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Mechanistic studies of the acid hyrolysis of N-Vinyl-2-Pyrrolidone at pH <2.5. | Author: Hawi et. al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Über ein dimeres N-Vinylpyrrolidon und das 1,1-Bis-(1'-pyrrolidonyl)-äthan (on a dimer N-vinylpyrroldone and the 1,1-bis-(1'-pyrrolidonly)-ethane) | Author: Breitenbach J.W. et al. | Year: 1956 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Biodegradation in soil | Waiver | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for n-Vinylpyrrolidone (CASRN: 88-12-0) using USEPA BCFBAFWIN v3.0 (April 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for n-Vinylpyrrolidone (CASRN: 88-12-0) using USEPA BCFBAFWIN v3.0 (April 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation of Adsorption / Desorption (Koc) for n-Vinylpyrrolidone (CASRN: 88-12-0) using USEPA KOCWIN v2.0 (February 2009) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Estimation of Adsorption / Desorption (Koc) for n-Vinylpyrrolidone (CASRN: 88-12-0) using USEPA KOCWIN v2.0 (February 2009) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry''s Law Constant | Robust Study Summary -- Title: Estimation of Henry's Law Constant for n-Vinylpyrrolidone (CASRN: 88-12-0) using USEPA HenryWin v3.20 (October 2008) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry''s Law Constant | Right to refer to study -- Title: Estimation of Henry's Law Constant for n-Vinylpyrrolidone (CASRN: 88-12-0) using USEPA HenryWin v3.20 (October 2008) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Waiver | - |
| Eco-Tox | Sediment toxicity | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial plants | Waiver | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition and metabolism of N-Vinyl Pyrrolidone in the Rat | Author: McClanahan J. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition and Pharmocokinetics of NVP | Author: Digenis G.A. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Disposition and Pharmocokinetics of NVP | Author: Digenis G.A. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: European Union Risk Assessment Report: 1-vinyl-2-pyrrolidone, CAS: 88-12-0, 2nd Priority List, Volume 39 | Author: European Commission | Year: 2003 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- GLP: . | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: European Union Risk Assessment Report: 1-vinyl-2-pyrrolidone, CAS: 88-12-0, 2nd Priority List, Volume 39 | Author: European Commission | Year: 2003 | Guideline: 402 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: ACUTE PERCUTANEOUS TOXICITY TO RATS OF n-VINYL PYRROLIDONE | Author: Kynoch S.R., Lloyd G.K. and Andrews C.D. | Year: 1978 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Two year inhalation study on N-vinylpyrrolidone-2 (NVP) as a vapor in Sprague-Dawley rats with interim kills of satellite subgroups after 3 and 12 months exposure and a third satellite subgroup that was exposed for 18 months and killed at 2 yrs. | Author: BASF/ISP | Year: 1992 | Guideline: 451 / EPA OTS 798.3300 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Two year inhalation study on N-vinylpyrrolidone-2 (NVP) as a vapor in Sprague-Dawley rats with interim kills of satellite subgroups after 3 and 12 months exposure and a third satellite subgroup that was exposed for 18 months and killed at 2 yrs. | Author: BASF/ISP | Year: 1992 | Guideline: 451 / EPA OTS 798.3300 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Ames test for vinylpyrrolidon | Author: BASF AG | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Ames test for vinylpyrrolidon | Author: BASF AG | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of V-pyrol (N-vinyl-2-pyrrolidone) in the In Vitro Transformation of BALB/3T3 Cells Assay | Author: GAF | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Evaluation of V-pyrol (N-vinyl-2-pyrrolidone) in the In Vitro Transformation of BALB/3T3 Cells Assay | Author: GAF | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity Evaluation of V-Pyrol (N-Vinyl-2-Pyrrolidone) in the Mouse Lymphoma Forward Mutation Assay | Author: GAF | Year: 1980 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Mutagenicity Evaluation of V-Pyrol (N-Vinyl-2-Pyrrolidone) in the Mouse Lymphoma Forward Mutation Assay | Author: GAF | Year: 1980 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Evaluation of V-Pyrol (N-vinyl-2-pyrrolidone) in the Primary Rat Hepatocyte Unscheduled DNA Synthesis Assay | Author: GAF | Year: 1980 | Guideline: 482 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Evaluation of V-Pyrol (N-vinyl-2-pyrrolidone) in the Primary Rat Hepatocyte Unscheduled DNA Synthesis Assay | Author: GAF | Year: 1980 | Guideline: 482 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic study in vivo of N-Vinylpyrrolidone-2 (NVP) in mice | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Cytogenetic study in vivo of N-Vinylpyrrolidone-2 (NVP) in mice | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Two year inhalation study on N-vinylpyrrolidone-2 (NVP) as vapor in Sprague-Dawley rats with interim kills of satellite subgroups after 3-month and 12-month exposure periods and a 3rd satellite subgroup that was exposed for 18 months and killed at 2 yrs | Author: BASF AG | Year: 1992 | Guideline: 451 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Two year inhalation study on N-vinylpyrrolidone-2 (NVP) as vapor in Sprague-Dawley rats with interim kills of satellite subgroups after 3-month and 12-month exposure periods and a 3rd satellite subgroup that was exposed for 18 months and killed at 2 yrs | Author: BASF AG | Year: 1992 | Guideline: 451 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long-term inhalation toxicity of N-Vinylpyrrolidone-2 Vapours. Studies in Rats | Author: Klimisch et. al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Waiver | - |